AMGN vs PTCT vs GILD Stock Comparison

Amgen, Ptc Therapeutics and Gilead Sciences Prices as of Oct 29, 2026 Peers: Industry group
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AMGN Amgen Inc
$460.73 +8.8% 1M +57.9% 1Y
Market cap
$252.29B
P/E
28.9x
Revenue (TTM)
$38.10B
Div. yield
0.02%
Biotechnology Healthcare
5 wins
GILD Gilead Sciences, Inc.
$165.61 +9.5% 1M +39.8% 1Y
Market cap
$213.47B
P/E
–
Revenue (TTM)
$30.99B
Div. yield
–
Biotechnology Healthcare
3 wins

Head to Head

10 decided of 12

Amgen leads on 5 of the 12 questions below (Amgen 5, Gilead Sciences 3, Ptc Therapeutics 2). Which ones matter depends on what you are buying for; a cheap multiple and slow growth often come together.

QuestionAMGNPTCTGILDLeader
Larger companyMarket capitalisation $252.29B $5.05B $213.47B AMGN
Cheaper on earningsLower P/E, profitable companies only 28.9x -47.6x -58.0x –
Cheaper on forward earningsLower price / next fiscal year consensus EPS 21.1x 58.6x — AMGN
Faster revenue growthRevenue growth, trailing twelve months +9.1% -35.1% +6.5% AMGN
More profitableNet margin, trailing twelve months 23.0% -9.2% — AMGN
Better return on capitalReturn on invested capital 14.3% 21.0% — PTCT
Less leveragedLower net debt / EBITDA 2.7x -6.0x — PTCT
Higher dividend yieldTrailing dividend yield 0.02% 0.00% 0.00% –
Better 1-year returnPrice return, last 12 months +57.9% -4.3% +39.8% AMGN
Better 5-year returnAnnualised price return, 5 years +17.4%/yr +11.2%/yr +20.6%/yr GILD
Less volatileAnnualised volatility, 1 year 29.7% 40.8% 27.1% GILD
Higher overall scoreMean of the five percentile scores vs peers 66/100 63/100 71/100 GILD

Percentile Scorecard

AMGNPTCTGILD

Each axis is the mean percentile of its metrics against the company's industry group. 100 is the best in the group, 50 the middle.

Scores by Axis

AxisAMGNPTCTGILD
Valuation 85 #95 of 624 96 #29 of 624 86 #87 of 624
Growth 61 #234 of 601 40 #364 of 601 43 #346 of 601
Profitability 94 #31 of 541 87 #69 of 541 90 #57 of 541
Financial Health 21 #509 of 647 36 #417 of 647 –
Shareholder Returns 68 #114 of 359 56 #157 of 359 66 #124 of 359
Overall 66 63 71
  • AMGN ranked among 671 companies in Pharmaceuticals and Biotechnology
  • PTCT ranked among 671 companies in Pharmaceuticals and Biotechnology
  • GILD ranked among 671 companies in Pharmaceuticals and Biotechnology

Price Performance

Price return, split-adjusted, before dividends. Click a name to hide or show it.

Returns

PeriodAMGNPTCTGILDSPY
1 month +8.8%-0.8%+9.5% +0.7%
3 months +18.9%-14.6%+26.2% +3.7%
6 months +33.1%-0.9%+26.6% +7.1%
Year to date +40.8%-15.1%+34.9% +12.8%
1 year +57.9%-4.3%+39.8% +11.9%
3 years +75.1%+244.0%+112.9% +85.2%
3 years, per year +20.5%+51.0%+28.7% +22.8%
5 years +122.6%+69.9%+155.3% +67.6%
5 years, per year +17.4%+11.2%+20.6% +10.9%
10 years +217.4%+908.8%+124.2% +262.0%
10 years, per year +12.2%+26.0%+8.4% +13.7%

Risk

MeasureAMGNPTCTGILDSPY
Volatility, 1Y 29.7%40.8%27.1% 12.7%
Downside volatility, 1Y 28.0%41.1%23.9% 12.6%
Beta vs S&P 500, 1Y 0.450.710.29 1.00
Return / volatility, 1Y 1.95-0.111.47 0.94
Max drawdown, 5Y -26.7%-69.4%-29.4% -25.4%
From 52-week high 0.0%-28.0%0.0% -1.2%
52-week high $460.73$89.55$165.61 $779.14
52-week low $291.77$59.24$118.15 $631.97

Valuation History

Weekly multiples on trailing twelve-month fundamentals. Negative or extreme readings (a loss year, a collapsed denominator) are left out so the chart stays readable.

MultipleAMGNPTCTGILD
P/E now vs peer median 28.5xmedian 17.8x -50.8xmedian 17.8x -58.0xmedian 17.8x
P/S now vs peer median 6.5xmedian 9.1x 4.7xmedian 9.1x 6.6xmedian 9.1x
EV/EBITDA now vs peer median 18.2xmedian 15.0x 19.5xmedian 15.0x —median 15.0x
P/FCF now vs peer median 24.5xmedian 21.7x 2,605xmedian 21.7x 14.5xmedian 21.7x
P/B now vs peer median 21.3xmedian 2.2x -28.2xmedian 2.2x 15.9xmedian 2.2x
PEG now vs peer median 10.73median 0.35 -1.08median 0.35 —median 0.35

Financial History

Reported figures by fiscal period, placed on the calendar year (or quarter) each period ended in, so companies with different fiscal years line up.

Trailing twelve monthsAMGNPTCTGILD
Revenue $38.10B $1.16B $30.99B
Gross profit $26.48B $1.08B –
Operating income $11.43B $147.70M -$2.36B
Net income $8.74B -$105.97M –
Free cash flow $10.18B $2.07M –
R&D $7.63B $438.50M $6.33B
EPS (diluted) $16.07 $-1.27 –
Cash & equivalents $13.99B $508.89M –
Total debt $57.30B $855.35M –
Shares (diluted) 544.00M 83.48M 1.24B
Enterprise value $207.69B -$3.15B $213.47B

All Metrics

58 metrics · best in bold

Bold marks the best reading: the lowest positive value for multiples, leverage and payout, the highest for everything else. The bar under each value is its percentile against that company's own peers. Hover a value for its rank and the peer median.

Valuation

12 metrics
MetricAMGNPTCTGILD
P/E 28.5x -50.8x -58.0x
P/FCF 24.5x 2,605x 14.5x
P/Operating cash flow 20.0x 513.5x 14.2x
P/S 6.5x 4.7x 6.6x
P/B 21.3x -28.2x 15.9x
P/Tangible book -28.3x -8.5x -438.2x
EV/EBITDA 18.2x 19.5x –
EV/EBIT 25.6x 27.8x –
EV/Revenue 7.7x 3.6x 6.6x
EV/FCF 28.7x 1,989x –
EV/Operating cash flow 23.4x 392.1x 14.2x
PEG (3Y EPS CAGR) 10.73 -1.08 –

Growth

14 metrics
MetricAMGNPTCTGILD
Revenue growth (1Y) 9.1% -35.1% 6.5%
Revenue CAGR (3Y) 12.7% 13.1% 4.2%
Gross profit growth (1Y) 17.6% -37.5% –
Gross profit CAGR (3Y) 10.3% 12.8% –
Operating income growth (1Y) 39.5% -81.0% -122.5%
Operating income CAGR (3Y) 6.4% 30.6% -31.7%
Net income growth (1Y) 32.1% -114.1% –
Net income CAGR (3Y) 3.1% 45.1% –
EPS growth (1Y) 31.4% -114.7% –
EPS CAGR (3Y) 2.7% 47.0% –
Operating cash flow growth (1Y) 3.9% -98.5% 49.8%
Operating cash flow CAGR (3Y) 4.9% 27.0% 19.9%
Free cash flow growth (1Y) -4.1% -99.7% –
Free cash flow CAGR (3Y) 1.7% 26.2% –

Profitability

14 metrics
MetricAMGNPTCTGILD
Gross margin 69.5% 93.2% –
EBITDA margin 42.2% 18.2% –
Operating margin 30.0% 12.8% –
Pretax margin 27.0% -7.4% –
Net margin 23.0% -9.2% –
FCF margin 26.7% 0.2% –
Operating cash flow margin 32.8% 0.9% 46.7%
Return on equity 83.8% – -31.2%
Return on assets 9.3% -3.3% -7.7%
Return on invested capital 14.3% 21.0% –
Return on capital employed 16.7% 6.0% –
Asset turnover 0.4x 0.4x 0.6x
Cash conversion (OCF / net income) 1.4x -0.1x –
Stock comp / revenue 1.3% 7.7% –

Financial Health

11 metrics
MetricAMGNPTCTGILD
Debt / assets 59.9% 26.7% –
Debt / equity 4.9x -4.5x –
Net debt / EBITDA 2.7x -6.0x –
Debt / FCF 5.6x 413.8x –
Liabilities / assets 87.8% 106.0% –
Equity / assets 12.2% -6.0% 25.2%
Interest coverage 4.3x – –
Current ratio 1.4x 3.3x –
Quick ratio 0.9x 3.0x –
Cash ratio 0.5x 2.7x –
Altman Z-score 2.37 0.84 –

Shareholder Returns

7 metrics
MetricAMGNPTCTGILD
Dividend yield 2.2% – 2.0%
Net buyback yield – -1.7% –
Shareholder yield 2.2% -1.7% 2.0%
Payout ratio (earnings) 60.4% – –
Payout ratio (FCF) 51.9% – –
Dividend growth (1Y) 6.3% – –
Dividend CAGR (3Y) 6.7% – –

Analyst Estimates

Solid lines are reported fiscal-year results; dashed lines are the consensus for the years ahead. Hover a year for the analysts' high and low, and how each result compared with its estimate.

ConsensusAMGNPTCTGILD
Forward P/E 21.1xFY2026 58.6xFY2026 –
EPS, next fiscal year $21.81FY2026 $1.10FY2026 $-0.39FY2026
EPS growth, next FY -0.1%FY2026 -85.9%FY2026 -104.8%FY2026
EPS growth, the year after +7.2% +125.5% –
Revenue, next fiscal year $41.51BFY2026 $1.33BFY2026 $28.65BFY2026
Revenue growth, next FY +12.9%FY2026 -23.2%FY2026 -2.7%FY2026
Revenue growth, the year after +2.3% -1.0% +18.1%

Institutional Ownership

13F filings, quarter ended Jun 30, 2026
HoldersAMGNPTCTGILD
Held by institutions 82.7% 100.0% 89.6%
Institutions holding 3,161 382 2,291
Change in shares held, QoQ +4.5% +5.0% +5.1%
Institutions buying 1,452 218 1,113
Institutions selling 1,218 111 851
Buyers to sellers 1.19 1.96 1.31

Return Correlation

Daily returns, last 12 months

1.00 means two stocks move in lockstep, 0 that they move independently. Pairs below about 0.5 diversify each other.

AMGNPTCTGILD
AMGN 1.00 0.27 0.52
PTCT 0.27 1.00 0.25
GILD 0.52 0.25 1.00

Add a Peer

Largest companies in the same industry

Related Comparisons

Frequently Asked Questions

Which is bigger, AMGN, PTCT and GILD?

Amgen (AMGN) is the largest by market capitalisation: Amgen (AMGN) $252.29B, Ptc Therapeutics (PTCT) $5.05B, Gilead Sciences (GILD) $213.47B.

Which company is growing faster?

Amgen (AMGN) grew revenue fastest over the trailing twelve months: Amgen (AMGN) +9.1%, Ptc Therapeutics (PTCT) -35.1%, Gilead Sciences (GILD) +6.5%.

Which company is more profitable?

Amgen (AMGN) has the highest net margin (Amgen (AMGN) 23.0%, Ptc Therapeutics (PTCT) -9.2%). On return on invested capital, Ptc Therapeutics (PTCT) leads (Amgen (AMGN) 14.3%, Ptc Therapeutics (PTCT) 21.0%).

Which stock has performed better?

Over the past year Amgen (AMGN) returned the most: Amgen (AMGN) +57.9%, Ptc Therapeutics (PTCT) -4.3%, Gilead Sciences (GILD) +39.8%. Over five years, Gilead Sciences (GILD) compounded fastest (Amgen (AMGN) +17.4%/yr, Ptc Therapeutics (PTCT) +11.2%/yr, Gilead Sciences (GILD) +20.6%/yr). Returns are price only, before dividends.

Which pays a higher dividend?

Only one of these companies pays a dividend: Amgen (AMGN) 0.02%, Ptc Therapeutics (PTCT) 0.00%, Gilead Sciences (GILD) 0.00%. Ptc Therapeutics (PTCT) and Gilead Sciences (GILD) pays no regular dividend.

Which stock is riskier?

By one-year price volatility, Gilead Sciences (GILD) has been the steadiest (Amgen (AMGN) 29.7%, Ptc Therapeutics (PTCT) 40.8%, Gilead Sciences (GILD) 27.1%). Volatility measures how widely the price swings, not the risk of the business.

Which is the better stock, AMGN, PTCT and GILD?

There is no single answer; it depends on what you are buying for. On the 12 head-to-head measures on this page, Amgen (AMGN) leads on 5. Business Quant does not give investment advice; use the comparison as a starting point for your own research.

Data from SEC filings, exchange prices and consensus estimates, via Business Quant. Percentile scores compare each company with its own peer group, so two companies' scores are each relative to different peers unless you rank against the whole market. Price returns exclude dividends. Nothing on this page is investment advice.