AMGN vs BNTX vs BIIB Stock Comparison

Amgen, BioNTech SE and Biogen Prices as of Nov 5, 2026 Peers: Industry group
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AMGN Amgen Inc
$460.28 +14.3% 1M +43.9% 1Y
Market cap
$249.20B
P/E
26.5x
Revenue (TTM)
$38.90B
Div. yield
0.02%
Biotechnology Healthcare
9 wins
BNTX BioNTech SE
$85.86 -10.3% 1M -17.0% 1Y
Market cap
$21.15B
P/E
–
Revenue (TTM)
$2.80B
Div. yield
–
Biotechnology Healthcare
BIIB Biogen Inc.
$243.93 +9.4% 1M +59.0% 1Y
Market cap
$36.74B
P/E
105.7x
Revenue (TTM)
$10.30B
Div. yield
–
Biotechnology Healthcare
2 wins

Head to Head

11 decided of 12

Amgen leads on 9 of the 12 questions below (Amgen 9, Biogen 2). Which ones matter depends on what you are buying for; a cheap multiple and slow growth often come together.

QuestionAMGNBNTXBIIBLeader
Larger companyMarket capitalisation $249.20B $21.15B $36.74B AMGN
Cheaper on earningsLower P/E, profitable companies only 26.5x -12.3x 105.7x AMGN
Cheaper on forward earningsLower price / next fiscal year consensus EPS 21.1x — 18.9x BIIB
Faster revenue growthRevenue growth, trailing twelve months +8.2% -20.8% +2.3% AMGN
More profitableNet margin, trailing twelve months 24.1% -61.4% 3.4% AMGN
Better return on capitalReturn on invested capital 15.6% -10.2% 1.3% AMGN
Less leveragedLower net debt / EBITDA 2.4x 12.2x 4.5x AMGN
Higher dividend yieldTrailing dividend yield 0.02% 0.00% 0.00% –
Better 1-year returnPrice return, last 12 months +43.9% -17.0% +59.0% BIIB
Better 5-year returnAnnualised price return, 5 years +16.6%/yr -16.9%/yr -2.6%/yr AMGN
Less volatileAnnualised volatility, 1 year 29.2% 47.1% 34.4% AMGN
Higher overall scoreMean of the five percentile scores vs peers 66/100 61/100 59/100 AMGN

Percentile Scorecard

AMGNBNTXBIIB

Each axis is the mean percentile of its metrics against the company's industry group. 100 is the best in the group, 50 the middle.

Scores by Axis

AxisAMGNBNTXBIIB
Valuation 86 #92 of 634 87 #85 of 634 92 #52 of 634
Growth 62 #233 of 608 10 #545 of 608 25 #455 of 608
Profitability 94 #33 of 557 73 #153 of 557 87 #74 of 557
Financial Health 22 #508 of 654 88 #79 of 654 33 #440 of 654
Shareholder Returns 66 #138 of 403 49 #208 of 403 –
Overall 66 61 59
  • AMGN ranked among 671 companies in Pharmaceuticals and Biotechnology
  • BNTX ranked among 671 companies in Pharmaceuticals and Biotechnology
  • BIIB ranked among 671 companies in Pharmaceuticals and Biotechnology

Price Performance

Price return, split-adjusted, before dividends. Click a name to hide or show it.

Returns

PeriodAMGNBNTXBIIBSPY
1 month +14.3%-10.3%+9.4% -5.9%
3 months +13.7%-5.8%+18.3% -4.6%
6 months +39.9%-7.7%+27.5% +0.2%
Year to date +40.6%-9.8%+38.6% +7.5%
1 year +43.9%-17.0%+59.0% +8.2%
3 years +68.7%-13.9%-1.9% +68.3%
3 years, per year +19.1%-4.9%-0.6% +19.0%
5 years +115.3%-60.4%-12.5% +56.5%
5 years, per year +16.6%-16.9%-2.6% +9.4%
10 years +239.9%—-11.9% +251.5%
10 years, per year +13.0%—-1.3% +13.4%

Risk

MeasureAMGNBNTXBIIBSPY
Volatility, 1Y 29.2%47.1%34.4% 13.6%
Downside volatility, 1Y 28.3%47.0%33.2% 14.2%
Beta vs S&P 500, 1Y 0.501.030.32 1.00
Return / volatility, 1Y 1.50-0.361.72 0.60
Max drawdown, 5Y -26.7%-78.4%-64.4% -25.4%
From 52-week high -3.8%-28.1%-4.1% -5.9%
52-week high $478.48$119.34$254.46 $779.14
52-week low $313.85$83.89$153.43 $631.97

Valuation History

Weekly multiples on trailing twelve-month fundamentals. Negative or extreme readings (a loss year, a collapsed denominator) are left out so the chart stays readable.

MultipleAMGNBNTXBIIB
P/E now vs peer median 26.5xmedian 17.8x -12.1xmedian 17.8x 103.7xmedian 17.8x
P/S now vs peer median 6.4xmedian 8.1x 7.8xmedian 8.1x 3.5xmedian 8.1x
EV/EBITDA now vs peer median 17.0xmedian 15.7x -7.5xmedian 15.7x 31.7xmedian 15.7x
P/FCF now vs peer median 26.0xmedian 21.0x -788.2xmedian 21.0x 17.4xmedian 21.0x
P/B now vs peer median 17.3xmedian 2.0x 1.1xmedian 2.0x 1.9xmedian 2.0x
PEG now vs peer median 3.82median 0.36 0.32median 0.36 -2.70median 0.36

Financial History

Reported figures by fiscal period, placed on the calendar year (or quarter) each period ended in, so companies with different fiscal years line up.

Trailing twelve monthsAMGNBNTXBIIB
Revenue $38.90B $2.80B $10.30B
Gross profit $27.58B $2.10B $7.62B
Operating income $12.61B -$2.13B $445.10M
Net income $9.39B -$1.72B $347.50M
Free cash flow $9.58B -$27.55M $2.07B
R&D $7.84B $2.74B $2.15B
EPS (diluted) $17.20 $-7.11 $2.35
Cash & equivalents $13.19B $11.57B $1.30B
Total debt $54.01B $123.50M $7.29B
Shares (diluted) 546.00M 241.70M 147.80M
Enterprise value $200.85B -$38.36B $26.05B

All Metrics

58 metrics · best in bold

Bold marks the best reading: the lowest positive value for multiples, leverage and payout, the highest for everything else. The bar under each value is its percentile against that company's own peers. Hover a value for its rank and the peer median.

Valuation

12 metrics
MetricAMGNBNTXBIIB
P/E 26.5x -12.1x 103.7x
P/FCF 26.0x -788.2x 17.4x
P/Operating cash flow 20.7x -80.5x 16.0x
P/S 6.4x 7.8x 3.5x
P/B 17.3x 1.1x 1.9x
P/Tangible book -48.0x 1.1x 6.5x
EV/EBITDA 17.0x -7.5x 31.7x
EV/EBIT 23.0x -3.9x 94.5x
EV/Revenue 7.4x 3.0x 4.1x
EV/FCF 30.2x -301.6x 20.3x
EV/Operating cash flow 24.1x -30.8x 18.7x
PEG (3Y EPS CAGR) 3.82 0.32 -2.70

Growth

14 metrics
MetricAMGNBNTXBIIB
Revenue growth (1Y) 8.2% -20.8% 2.3%
Revenue CAGR (3Y) 13.2% -25.9% 1.0%
Gross profit growth (1Y) 15.9% -28.3% 0.6%
Gross profit CAGR (3Y) 11.8% -30.5% 0.5%
Operating income growth (1Y) 45.4% -107.5% -76.6%
Operating income CAGR (3Y) 12.5% -37.6% -34.8%
Net income growth (1Y) 34.1% -172.4% -78.4%
Net income CAGR (3Y) 7.5% -37.6% -38.1%
EPS growth (1Y) 33.1% -164.3% -78.5%
EPS CAGR (3Y) 6.9% -38.0% -38.5%
Operating cash flow growth (1Y) -8.3% -13.4% -8.4%
Operating cash flow CAGR (3Y) 4.4% -27.0% 18.2%
Free cash flow growth (1Y) -17.0% 35.2% -10.1%
Free cash flow CAGR (3Y) 0.7% -26.1% 24.9%

Profitability

14 metrics
MetricAMGNBNTXBIIB
Gross margin 70.9% 74.9% 74.0%
EBITDA margin 43.9% -39.3% 12.9%
Operating margin 32.4% -76.0% 4.3%
Pretax margin 28.4% -59.7% 4.3%
Net margin 24.1% -61.4% 3.4%
FCF margin 24.6% -1.0% 20.1%
Operating cash flow margin 30.9% -9.6% 21.8%
Return on equity 72.1% -9.4% 1.8%
Return on assets 9.8% -8.2% 1.1%
Return on invested capital 15.6% -10.2% 1.3%
Return on capital employed 17.4% -9.3% 1.6%
Asset turnover 0.4x 0.1x 0.3x
Cash conversion (OCF / net income) 1.3x 0.2x 6.5x
Stock comp / revenue 1.3% 3.6% 2.9%

Financial Health

11 metrics
MetricAMGNBNTXBIIB
Debt / assets 56.2% 0.5% 22.7%
Debt / equity 3.8x 0.0x 0.4x
Net debt / EBITDA 2.4x 12.2x 4.5x
Debt / FCF 5.6x -4.5x 3.5x
Liabilities / assets 85.1% 12.2% 41.0%
Equity / assets 14.9% 87.8% 59.0%
Interest coverage 4.8x -57.9x –
Current ratio 1.5x 64.2x 1.9x
Quick ratio 1.0x 51.6x 0.9x
Cash ratio 0.6x 48.8x 0.3x
Altman Z-score 2.52 6.56 3.07

Shareholder Returns

7 metrics
MetricAMGNBNTXBIIB
Dividend yield 2.2% – –
Net buyback yield – -3.7% –
Shareholder yield 2.2% -3.7% –
Payout ratio (earnings) 57.1% – –
Payout ratio (FCF) 56.0% – –
Dividend growth (1Y) 6.3% – –
Dividend CAGR (3Y) 6.4% – –

Analyst Estimates

Solid lines are reported fiscal-year results; dashed lines are the consensus for the years ahead. Hover a year for the analysts' high and low, and how each result compared with its estimate.

ConsensusAMGNBNTXBIIB
Forward P/E 21.1xFY2026 – 18.9xFY2026
EPS, next fiscal year $21.81FY2026 $-6.13FY2026 $12.94FY2026
EPS growth, next FY -0.1%FY2026 – -15.3%FY2026
EPS growth, the year after +7.2% – +33.9%
Revenue, next fiscal year $41.51BFY2026 $1.94BFY2026 $10.07BFY2026
Revenue growth, next FY +12.9%FY2026 -42.4%FY2026 +1.9%FY2026
Revenue growth, the year after +2.3% +13.5% +11.5%

Institutional Ownership

13F filings, quarter ended Jun 30, 2026
HoldersAMGNBNTXBIIB
Held by institutions 82.7% 19.4% 96.4%
Institutions holding 3,163 283 1,038
Change in shares held, QoQ +4.5% -1.2% +6.0%
Institutions buying 1,452 136 549
Institutions selling 1,219 73 294
Buyers to sellers 1.19 1.86 1.87

Return Correlation

Daily returns, last 12 months

1.00 means two stocks move in lockstep, 0 that they move independently. Pairs below about 0.5 diversify each other.

AMGNBNTXBIIB
AMGN 1.00 0.37 0.50
BNTX 0.37 1.00 0.23
BIIB 0.50 0.23 1.00

Add a Peer

Largest companies in the same industry

Related Comparisons

Frequently Asked Questions

Which is bigger, AMGN, BNTX and BIIB?

Amgen (AMGN) is the largest by market capitalisation: Amgen (AMGN) $249.20B, BioNTech SE (BNTX) $21.15B, Biogen (BIIB) $36.74B.

Which stock is cheaper, AMGN, BNTX and BIIB?

Amgen (AMGN) trades on the lowest price-to-earnings ratio (Amgen (AMGN) 26.5x, BioNTech SE (BNTX) -12.3x, Biogen (BIIB) 105.7x). On next year's consensus earnings, Biogen (BIIB) is cheapest (Amgen (AMGN) 21.1x, Biogen (BIIB) 18.9x). A lower multiple can reflect slower expected growth, so read it next to the growth figures.

Which company is growing faster?

Amgen (AMGN) grew revenue fastest over the trailing twelve months: Amgen (AMGN) +8.2%, BioNTech SE (BNTX) -20.8%, Biogen (BIIB) +2.3%.

Which company is more profitable?

Amgen (AMGN) has the highest net margin (Amgen (AMGN) 24.1%, BioNTech SE (BNTX) -61.4%, Biogen (BIIB) 3.4%). On return on invested capital, Amgen (AMGN) leads (Amgen (AMGN) 15.6%, BioNTech SE (BNTX) -10.2%, Biogen (BIIB) 1.3%).

Which stock has performed better?

Over the past year Biogen (BIIB) returned the most: Amgen (AMGN) +43.9%, BioNTech SE (BNTX) -17.0%, Biogen (BIIB) +59.0%. Over five years, Amgen (AMGN) compounded fastest (Amgen (AMGN) +16.6%/yr, BioNTech SE (BNTX) -16.9%/yr, Biogen (BIIB) -2.6%/yr). Returns are price only, before dividends.

Which pays a higher dividend?

Only one of these companies pays a dividend: Amgen (AMGN) 0.02%, BioNTech SE (BNTX) 0.00%, Biogen (BIIB) 0.00%. BioNTech SE (BNTX) and Biogen (BIIB) pays no regular dividend.

Which stock is riskier?

By one-year price volatility, Amgen (AMGN) has been the steadiest (Amgen (AMGN) 29.2%, BioNTech SE (BNTX) 47.1%, Biogen (BIIB) 34.4%). Volatility measures how widely the price swings, not the risk of the business.

Which is the better stock, AMGN, BNTX and BIIB?

There is no single answer; it depends on what you are buying for. On the 12 head-to-head measures on this page, Amgen (AMGN) leads on 9. Business Quant does not give investment advice; use the comparison as a starting point for your own research.

Data from SEC filings, exchange prices and consensus estimates, via Business Quant. Percentile scores compare each company with its own peer group, so two companies' scores are each relative to different peers unless you rank against the whole market. Price returns exclude dividends. Nothing on this page is investment advice.