Zentalis Pharmaceuticals, Inc. (ZNTL) Institutional Ownership

Institutions by Trading Activity

Ownership Statistics

0Shares Outstanding

16,225,818Shares held by institutions

$34,642,121Value of institutional holdings

77.95%Institutional ownership %

-1.71%Shares Changed QoQ

115No. of institutional investors

Shares Owned by Institutions

Shares Purchased/Sold by Institutions

Ownership Summary

Zentalis Pharmaceuticals, Inc. (NASDAQ:ZNTL) has 84 institutional investors with active 13F positions as of December 2025.

These investors collectively held 56.3% of Zentalis Pharmaceuticals's outstanding shares in December 2025, down from 76.2% in September 2025.
Their total shares held in ZNTL increased 10.64% quarter over quarter, and separately, investors owning Zentalis Pharmaceuticals decreased 40.0% from a year ago.
Activity in ZNTL broke down as 37 buyers, 32 sellers, and 15 unchanged among 84 total holders.
The aggregate institutional position in Zentalis Pharmaceuticals amounted to 40.6Mn shares as of December 2025, up by 3.91Mn shares quarter on quarter, and down 25.73Mn shares year over year.
5AM Venture Management, LLC leads ownership in ZNTL with 3.95Mn shares as of December 31, 2025, equal to 5.47% of outstanding shares.
Leading buyers of Zentalis Pharmaceuticals shares for the quarter ending December 2025 were 5AM Venture Management, LLC (3.46Mn), Ishara Investments LP (1.32Mn), Opaleye Management Inc. (1.08Mn), XTX Topco Ltd (576.71K), RENAISSANCE TECHNOLOGIES LLC (558.39K).
The largest sellers of Zentalis Pharmaceuticals for the quarter ending December 2025 were Bank Of America Corp /De/ (1.73Mn), Jpmorgan Chase & Co (1.26Mn), Morgan Stanley (604.18K), JACOBS LEVY EQUITY MANAGEMENT, INC (576.05K), Almitas Capital LLC (304.57K).
According to Business Quant data, leading holders of ZNTL for December 2025 are 5AM Venture Management, LLC (3.95Mn), RENAISSANCE TECHNOLOGIES LLC (2.88Mn), VANGUARD GROUP INC (2.86Mn), ACADIAN ASSET MANAGEMENT LLC (2.85Mn), CITADEL ADVISORS LLC (1.96Mn), D. E. Shaw & Co., Inc. (1.66Mn), TWO SIGMA ADVISERS, LP (1.48Mn), TWO SIGMA INVESTMENTS, LP (1.47Mn), Opaleye Management Inc. (1.4Mn), Bank Of America Corp /De/ (1.37Mn).

84 Institutional Holders

16,225,818 Total Shares Held

Rows:

Download Data

Owner Name	Date	Change (QoQ)	Change (%)	Value (USD)
BlackRock, Inc.	31 Dec, 2025	464	0.04%	$0.00
RENAISSANCE TECHNOLOGIES LLC	31 Dec, 2025	558,390	24.01%	$0.00
5AM Venture Management, LLC	31 Dec, 2025	3,457,913	705.70%	$0.00
Barclays Plc	31 Dec, 2025	331,578	139.99%	$0.00
VANGUARD GROUP INC	31 Dec, 2025	-48,810	-1.68%	$0.00
Decheng Capital LLC	31 Dec, 2025	0	0.00%	$0.00
ACADIAN ASSET MANAGEMENT LLC	31 Dec, 2025	4,142	0.15%	$0.00
Ishara Investments LP	31 Dec, 2025	1,320,000	0.00%	$0.00
CITADEL ADVISORS LLC	31 Dec, 2025	-113,035	-5.44%	$0.00
UBS Group AG	31 Dec, 2025	141,920	26.64%	$0.00
D. E. Shaw & Co., Inc.	31 Dec, 2025	251,575	17.86%	$0.00
XTX Topco Ltd	31 Dec, 2025	576,707	0.00%	$0.00
TWO SIGMA ADVISERS, LP	31 Dec, 2025	22,300	1.53%	$0.00
Woodline Partners LP	31 Dec, 2025	0	0.00%	$0.00
TWO SIGMA INVESTMENTS, LP	31 Dec, 2025	108,067	7.93%	$0.00
Peapod Lane Capital LLC	31 Dec, 2025	-116,510	-20.61%	$0.00
Opaleye Management Inc.	31 Dec, 2025	1,084,356	342.55%	$0.00
ADAR1 Capital Management, LLC	31 Dec, 2025	110,000	220.00%	$0.00
Bank Of America Corp /De/	31 Dec, 2025	-1,730,308	-55.86%	$0.00
Quadrature Capital Ltd	31 Dec, 2025	76,917	126.82%	$0.00

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