Zentalis Pharmaceuticals, Inc. (ZNTL) Institutional Ownership

Institutions by Trading Activity

Ownership Statistics

72,137,838Shares Outstanding

3,785,400Shares held by institutions

$8,933,544Value of institutional holdings

55.88%Institutional ownership %

17.89%Shares Changed QoQ

81No. of institutional investors

Shares Owned by Institutions

Shares Purchased/Sold by Institutions

Ownership Summary

A total of 81 institutions have reported a stake in Zentalis Pharmaceuticals, Inc. (NASDAQ:ZNTL) as of December 2025, according to recent 13F filings with the SEC.

These investors collectively held 55.9% of the company's total shares outstanding in December 2025, down from 73.0% in September 2025.
Institutional share ownership changed by 17.89% QoQ, while the number of institutional owners saw a decrease of 42.14% YoY.
Of these 81 institutional investors, 35 increased their holdings in Zentalis Pharmaceuticals, while 30 of them reduced positions, and 16 investors maintained their exposure.
The aggregate institutional position in Zentalis Pharmaceuticals now stands at 40.31Mn shares as of December 2025, after investors increased their holdings (up by 6.12Mn shares quarter on quarter which is down 23.92Mn shares year over year).
5AM Venture Management, LLC's holding of 3.95Mn shares as of December 31, 2025 makes it the primary institutional investor in Zentalis Pharmaceuticals, owning 5.47% of the stock.
Among the most significant buyers of Zentalis Pharmaceuticals during December 2025 were 5AM Venture Management, LLC (3.46Mn), Ishara Investments LP (1.32Mn), Opaleye Management Inc. (1.08Mn), XTX Topco Ltd (576.71K), RENAISSANCE TECHNOLOGIES LLC (558.39K).
Leading sellers of Zentalis Pharmaceuticals stock in December 2025 included MORGAN STANLEY (604.17K), JACOBS LEVY EQUITY MANAGEMENT, INC (576.05K), JPMORGAN CHASE & CO (538.07K), Almitas Capital LLC (304.57K), MILLENNIUM MANAGEMENT LLC (229.39K).
The top 10 institutional holders of Zentalis Pharmaceuticals for the quarter ending December 2025 included 5AM Venture Management, LLC (3.95Mn), RENAISSANCE TECHNOLOGIES LLC (2.88Mn), VANGUARD GROUP INC (2.86Mn), ACADIAN ASSET MANAGEMENT LLC (2.85Mn), CITADEL ADVISORS LLC (1.96Mn), D. E. Shaw & Co., Inc. (1.66Mn), TWO SIGMA ADVISERS, LP (1.48Mn), TWO SIGMA INVESTMENTS, LP (1.47Mn), Opaleye Management Inc. (1.40Mn), BANK OF AMERICA CORP /DE/ (1.37Mn).

81 Institutional Holders

3,785,400 Total Shares Held

Rows:

Download Data

Owner Name	Date	Shares Held	Change (QoQ)	Change (%)	Value (USD)
5AM Venture Management, LLC	31 Dec, 2025	3,947,913	3,457,913	705.70%	$5,329,683.00
RENAISSANCE TECHNOLOGIES LLC	31 Dec, 2025	2,883,745	558,390	24.01%	$3,893,056.00
VANGUARD GROUP INC	31 Dec, 2025	2,855,590	-48,810	-1.68%	$3,855,047.00
ACADIAN ASSET MANAGEMENT LLC	31 Dec, 2025	2,849,294	4,142	0.15%	$3,839.00
CITADEL ADVISORS LLC	31 Dec, 2025	1,964,255	-113,035	-5.44%	$2,651,744.00
D. E. Shaw & Co., Inc.	31 Dec, 2025	1,660,378	251,575	17.86%	$2,241,510.00
TWO SIGMA ADVISERS, LP	31 Dec, 2025	1,483,500	22,300	1.53%	$2,002,725.00
TWO SIGMA INVESTMENTS, LP	31 Dec, 2025	1,471,414	108,067	7.93%	$1,986,409.00
Opaleye Management Inc.	31 Dec, 2025	1,400,906	1,084,356	342.55%	$1,891,223.00
BANK OF AMERICA CORP /DE/	31 Dec, 2025	1,367,254	-181,527	-11.72%	$1,845,793.00
Decheng Capital LLC	31 Dec, 2025	1,323,327	0	0.00%	$1,786,491.00
Ishara Investments LP	31 Dec, 2025	1,320,000	1,320,000	0.00%	$1,782,000.00
BlackRock, Inc.	31 Dec, 2025	1,249,968	464	0.04%	$1,687,457.00
GSA CAPITAL PARTNERS LLP	31 Dec, 2025	1,169,573	91,917	8.53%	$1,579.00
PRIMECAP MANAGEMENT CO/CA/	31 Dec, 2025	957,420	-5,200	-0.54%	$1,292,517.00
PFIZER INC	31 Dec, 2025	953,834	0	0.00%	$1,287,675.00
MORGAN STANLEY	31 Dec, 2025	803,654	-604,175	-42.92%	$1,084,932.00
Connor, Clark & Lunn Investment Management Ltd.	31 Dec, 2025	787,055	406,233	106.67%	$1,062,524.00
UBS Group AG	31 Dec, 2025	674,598	141,920	26.64%	$910,707.00
MILLENNIUM MANAGEMENT LLC	31 Dec, 2025	673,129	-229,392	-25.42%	$908,724.00

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