Xencor Inc (XNCR) Institutional Ownership

Institutions by Trading Activity

Ownership Statistics

74,413,000Shares Outstanding

81,928,467Shares held by institutions

$1,024,105,838Value of institutional holdings

110.10%Institutional ownership %

1.23%Shares Changed QoQ

200No. of institutional investors

Shares Owned by Institutions

Shares Purchased/Sold by Institutions

Ownership Summary

Xencor Inc (NASDAQ:XNCR) has 200 institutional investors with active 13F positions as of December 2025.

These investors held 107.9% of outstanding shares in December 2025, down from 112.5% in September 2025.
Their total shares held in XNCR increased 1.08% quarter over quarter, and separately, investors owning Xencor increased 4.17% from a year ago.
Of these 200 funds, 89 grew their exposure to Xencor, 76 cut back, and 35 maintained positions.
Altogether, these fund groups held 80.28Mn shares in XNCR by December 2025, up by 855.13K shares quarter on quarter, and up 4.11Mn shares year over year.
As of December 31, 2025, BlackRock, Inc. held the largest stake in Xencor with 11.93Mn shares, accounting for 16.03% of total shares outstanding.
The largest buyers of Xencor for the quarter ending December 2025 were BVF INC/IL (4.39Mn), Defilade Capital Management, L.P. (1.41Mn), State Street Corp (833.42K), Lynx1 Capital Management LP (705.56K), Jefferies Financial Group Inc. (620.44K).
The largest sales of XNCR for the quarter ending December 2025 came from EcoR1 Capital, LLC (2.89Mn), Barclays Plc (997.02K), Nantahala Capital Management, LLC (935.36K), Bank Of America Corp /De/ (878.25K), BRAIDWELL LP (787.11K).
According to Business Quant data, leading holders of XNCR for December 2025 are BlackRock, Inc. (11.93Mn), PRIMECAP MANAGEMENT CO/CA/ (10.22Mn), VANGUARD GROUP INC (7.17Mn), BVF INC/IL (7.13Mn), RTW INVESTMENTS, LP (6.78Mn), State Street Corp (4.51Mn), EcoR1 Capital, LLC (3.25Mn), TCG Crossover Management, LLC (2.45Mn), GEODE CAPITAL MANAGEMENT, LLC (1.75Mn), Morgan Stanley (1.51Mn).

200 Institutional Holders

81,928,467 Total Shares Held

Rows:

Download Data

Owner Name	Date	Shares Held	Change (QoQ)	Change (%)	Value (USD)
BlackRock, Inc.	31 Dec, 2025	11,927,218	119,991	1.02%	$182,605,708.00
PRIMECAP MANAGEMENT CO/CA/	31 Dec, 2025	10,218,322	-456,700	-4.28%	$156,442,509.00
VANGUARD GROUP INC	31 Dec, 2025	7,165,450	61,692	0.87%	$109,703,040.00
BVF INC/IL	31 Dec, 2025	7,133,720	4,393,579	160.34%	$109,217,253.00
RTW INVESTMENTS, LP	31 Dec, 2025	6,777,461	556,407	8.94%	$103,762,928.00
State Street Corp	31 Dec, 2025	4,507,254	833,423	22.69%	$69,006,059.00
EcoR1 Capital, LLC	31 Dec, 2025	3,251,112	-2,893,655	-47.09%	$49,774,525.00
TCG Crossover Management, LLC	31 Dec, 2025	2,452,138	0	0.00%	$37,542,233.00
GEODE CAPITAL MANAGEMENT, LLC	31 Dec, 2025	1,752,918	24,093	1.39%	$26,842,201.00
Morgan Stanley	31 Dec, 2025	1,508,727	607,890	67.48%	$23,098,626.00
Goldman Sachs Group Inc	31 Dec, 2025	1,506,516	489,063	48.07%	$23,064,760.00
Johnson & Johnson	31 Dec, 2025	1,496,124	0	0.00%	$22,905,658.00
Defilade Capital Management, L.P.	31 Dec, 2025	1,414,755	1,414,755	0.00%	$21,659,899.00
Legal & General Group Plc	31 Dec, 2025	1,308,088	35,088	2.76%	$20,026,828.00
DIMENSIONAL FUND ADVISORS LP	31 Dec, 2025	1,249,288	-339,675	-21.38%	$19,125,117.00
BAKER BROS. ADVISORS LP	31 Dec, 2025	1,102,106	0	0.00%	$16,873,243.00
Jefferies Financial Group Inc.	31 Dec, 2025	720,440	620,440	620.44%	$11,029,936.00
Lynx1 Capital Management LP	31 Dec, 2025	705,558	705,558	0.00%	$10,802,093.00
CHARLES SCHWAB INVESTMENT MANAGEMENT INC	31 Dec, 2025	700,435	12,166	1.77%	$10,723,660.00
Northern Trust Corp	31 Dec, 2025	674,657	-37,544	-5.27%	$10,328,998.00

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