Xencor Inc (XNCR) Institutional Ownership

Institutions by Trading Activity

Ownership Statistics

75,337,500Shares Outstanding

5,053,268Shares held by institutions

$58,314,713Value of institutional holdings

105.86%Institutional ownership %

2.96%Shares Changed QoQ

194No. of institutional investors

Shares Owned by Institutions

Shares Purchased/Sold by Institutions

Ownership Summary

Recent 13F filings as of December 2025 show that 194 institutional investors hold a position in Xencor Inc (NASDAQ:XNCR).

Xencor saw its institutional ownership percentage fell to 105.9% in December 2025 from 108.9% in September 2025.
In percentage terms, this reflects as a holdings change of 2.96% quarter on quarter, and an increase of 1.04% year over year.
Among the 194 institutional holders of Xencor, 84 added to their stakes while 75 trimmed their positions and 35 held steady.
The total number of shares held by institutions in Xencor increased to 79.75Mn as of December 2025, a net change of up by 2.29Mn shares quarter on quarter, and up 4.89Mn shares year over year.
The top institutional stake in Xencor as of December 31, 2025 belongs to BlackRock, Inc., which owns 11.93Mn shares, or 15.83% of the company.
Among the most significant buyers of Xencor during December 2025 were BVF INC/IL (4.39Mn), Defilade Capital Management, L.P. (1.41Mn), STATE STREET CORP (833.42K), Lynx1 Capital Management LP (705.56K), Jefferies Financial Group Inc. (620.44K).
Leading sellers of Xencor stock in December 2025 included EcoR1 Capital, LLC (2.89Mn), Nantahala Capital Management, LLC (935.36K), BRAIDWELL LP (787.11K), UBS Group AG (537.25K), PRIMECAP MANAGEMENT CO/CA/ (456.70K).
The top 10 institutional holders of Xencor for the quarter ending December 2025 included BlackRock, Inc. (11.93Mn), PRIMECAP MANAGEMENT CO/CA/ (10.22Mn), VANGUARD GROUP INC (7.17Mn), BVF INC/IL (7.13Mn), RTW INVESTMENTS, LP (6.78Mn), STATE STREET CORP (4.51Mn), EcoR1 Capital, LLC (3.25Mn), TCG Crossover Management, LLC (2.45Mn), GEODE CAPITAL MANAGEMENT, LLC (1.75Mn), MORGAN STANLEY (1.51Mn).

194 Institutional Holders

5,053,268 Total Shares Held

Rows:

Download Data

Owner Name	Date	Shares Held	Change (QoQ)	Change (%)	Value (USD)
BlackRock, Inc.	31 Dec, 2025	11,927,218	119,991	1.02%	$182,605,708.00
PRIMECAP MANAGEMENT CO/CA/	31 Dec, 2025	10,218,322	-456,700	-4.28%	$156,442,509.00
VANGUARD GROUP INC	31 Dec, 2025	7,165,450	61,692	0.87%	$109,703,040.00
BVF INC/IL	31 Dec, 2025	7,133,720	4,393,579	160.34%	$109,217,253.00
RTW INVESTMENTS, LP	31 Dec, 2025	6,777,461	556,407	8.94%	$103,762,928.00
STATE STREET CORP	31 Dec, 2025	4,507,254	833,423	22.69%	$69,006,059.00
EcoR1 Capital, LLC	31 Dec, 2025	3,251,112	-2,893,655	-47.09%	$49,774,525.00
TCG Crossover Management, LLC	31 Dec, 2025	2,452,138	0	0.00%	$37,542,233.00
GEODE CAPITAL MANAGEMENT, LLC	31 Dec, 2025	1,752,918	24,093	1.39%	$26,842,201.00
MORGAN STANLEY	31 Dec, 2025	1,508,727	607,890	67.48%	$23,098,626.00
Defilade Capital Management, L.P.	31 Dec, 2025	1,414,755	1,414,755	0.00%	$21,659,899.00
Legal & General Group Plc	31 Dec, 2025	1,308,088	35,088	2.76%	$20,026,828.00
DIMENSIONAL FUND ADVISORS LP	31 Dec, 2025	1,249,288	-339,675	-21.38%	$19,125,117.00
BAKER BROS. ADVISORS LP	31 Dec, 2025	1,102,106	0	0.00%	$16,873,243.00
GOLDMAN SACHS GROUP INC	31 Dec, 2025	753,258	-264,195	-25.97%	$11,532,380.00
JOHNSON & JOHNSON	31 Dec, 2025	748,062	0	0.00%	$11,452,829.00
Jefferies Financial Group Inc.	31 Dec, 2025	720,440	620,440	620.44%	$11,029,936.00
Lynx1 Capital Management LP	31 Dec, 2025	705,558	705,558	0.00%	$10,802,093.00
CHARLES SCHWAB INVESTMENT MANAGEMENT INC	31 Dec, 2025	700,435	12,166	1.77%	$10,723,660.00
NORTHERN TRUST CORP	31 Dec, 2025	674,657	-37,544	-5.27%	$10,328,998.00

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