Xilio Therapeutics, Inc. (XLO) Institutional Ownership

Institutions by Trading Activity

Ownership Statistics

144,106,869Shares Outstanding

39,727,815Shares held by institutions

$331,727,255Value of institutional holdings

27.57%Institutional ownership %

102.61%Shares Changed QoQ

37No. of institutional investors

Shares Owned by Institutions

Shares Purchased/Sold by Institutions

Ownership Summary

Xilio Therapeutics, Inc. (NASDAQ:XLO) has 37 institutional investors that have filed 13F reports for the period ending December 2025.

These investors collectively held 27.6% of Xilio Therapeutics's outstanding shares in December 2025, up from 15.2% in September 2025.
They increased total shares held in Xilio Therapeutics by 102.61% from last quarter, and the number of investors in XLO increased 5.71% annually.
During the quarter, 16 of these 37 funds increased positions in XLO, 5 reduced exposure, and 16 held steady.
Altogether, these fund groups held 39.73Mn shares in XLO by December 2025, up by 20.12Mn shares quarter on quarter, and up 12.77Mn shares year over year.
Gilead Sciences, Inc. holds the largest position in XLO at 9.11Mn shares as of December 31, 2025, or 6.32% of shares outstanding.
The largest buyers of Xilio Therapeutics for the quarter ending December 2025 were Frazier Life Sciences Management, L.P. (5.92Mn), Point72 Asset Management, L.P. (4.0Mn), Bain Capital Life Sciences Investors, LLC (2.81Mn), Sio Capital Management, LLC (2.13Mn), STEMPOINT CAPITAL LP (2.03Mn).
The largest sellers of Xilio Therapeutics for the quarter ending December 2025 were Morgan Stanley (122.07K), TWO SIGMA INVESTMENTS, LP (25.76K), UBS Group AG (13.45K), LPL Financial LLC (10.0K), Bank Of America Corp /De/ (231).
Per Business Quant data, the top 10 holders of Xilio Therapeutics for the quarter ending December 2025 are Gilead Sciences, Inc. (9.11Mn), Bain Capital Life Sciences Investors, LLC (7.37Mn), Frazier Life Sciences Management, L.P. (5.92Mn), Point72 Asset Management, L.P. (4.0Mn), Sio Capital Management, LLC (2.13Mn), STEMPOINT CAPITAL LP (2.03Mn), Merck & Co., Inc. (1.48Mn), VANGUARD GROUP INC (1.26Mn), Empery Asset Management, LP (1.18Mn), Ghisallo Capital Management LLC (1.11Mn).

37 Institutional Holders

39,727,815 Total Shares Held

Rows:

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Owner Name	Date	Shares Held	Change (QoQ)	Change (%)	Value (USD)
Gilead Sciences, Inc.	31 Dec, 2025	9,105,451	0	0.00%	$5,829,310.00
Bain Capital Life Sciences Investors, LLC	31 Dec, 2025	7,372,686	2,805,869	61.44%	$4,719,994.00
Frazier Life Sciences Management, L.P.	31 Dec, 2025	5,915,091	5,915,091	0.00%	$3,786,841.00
Point72 Asset Management, L.P.	31 Dec, 2025	4,000,000	4,000,000	0.00%	$2,560,800.00
Sio Capital Management, LLC	31 Dec, 2025	2,134,537	2,134,537	0.00%	$1,366,531.00
STEMPOINT CAPITAL LP	31 Dec, 2025	2,030,028	2,030,028	0.00%	$1,299,624.00
Merck & Co., Inc.	31 Dec, 2025	1,483,758	0	0.00%	$949,902.00
VANGUARD GROUP INC	31 Dec, 2025	1,255,692	0	0.00%	$803,643.00
Empery Asset Management, LP	31 Dec, 2025	1,183,040	1,183,040	0.00%	$757,382.00
Ghisallo Capital Management LLC	31 Dec, 2025	1,113,222	1,113,222	0.00%	$712,685.00
Morgan Stanley	31 Dec, 2025	839,850	-122,067	-12.69%	$537,672.00
AJU IB Investment Co., Ltd.	31 Dec, 2025	667,742	0	0.00%	$427,488.00
FMR LLC	31 Dec, 2025	511,820	0	0.00%	$327,667.00
CITADEL ADVISORS LLC	31 Dec, 2025	436,216	436,216	0.00%	$279,265.00
RENAISSANCE TECHNOLOGIES LLC	31 Dec, 2025	344,416	139,716	68.25%	$220,495.00
GEODE CAPITAL MANAGEMENT, LLC	31 Dec, 2025	328,972	0	0.00%	$210,630.00
State Street Corp	31 Dec, 2025	186,390	22,500	13.73%	$119,327.00
Velan Capital Investment Management LP	31 Dec, 2025	170,000	170,000	0.00%	$108,834.00
GSA CAPITAL PARTNERS LLP	31 Dec, 2025	147,966	147,966	0.00%	$95.00
Stonepine Capital Management, LLC	31 Dec, 2025	126,270	126,270	0.00%	$80,838.00

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