Xilio Therapeutics, Inc. (XLO) Institutional Ownership

Institutions by Trading Activity

Ownership Statistics

144,106,869Shares Outstanding

39,727,815Shares held by institutions

$313,055,182Value of institutional holdings

27.57%Institutional ownership %

102.61%Shares Changed QoQ

37No. of institutional investors

Shares Owned by Institutions

Shares Purchased/Sold by Institutions

Ownership Summary

Xilio Therapeutics, Inc. (NASDAQ:XLO) appears in 37 institutional 13F filings for the quarter ending December 2025.

Collectively, these holders controlled 27.6% of Xilio Therapeutics's outstanding shares in December 2025, up from 15.2% in September 2025.
They increased total shares held in Xilio Therapeutics by 102.61% from last quarter, and the number of investors in XLO increased 5.71% annually.
Among the 37 funds, 16 bought more Xilio Therapeutics shares, 5 sold down, and 16 held their ground.
In total, institutional investors held 39.73Mn shares in Xilio Therapeutics as of December 2025, up by 20.12Mn shares quarter on quarter, and up 12.77Mn shares year over year.
Gilead Sciences, Inc. leads ownership in XLO with 9.11Mn shares as of December 31, 2025, equal to 6.32% of outstanding shares.
The biggest buyers of Xilio Therapeutics for the quarter ending December 2025 included Frazier Life Sciences Management, L.P. (5.92Mn), Point72 Asset Management, L.P. (4.0Mn), Bain Capital Life Sciences Investors, LLC (2.81Mn), Sio Capital Management, LLC (2.13Mn), STEMPOINT CAPITAL LP (2.03Mn).
Top sellers of XLO stock for the quarter ending December 2025 included Morgan Stanley (122.07K), TWO SIGMA INVESTMENTS, LP (25.76K), UBS Group AG (13.45K), LPL Financial LLC (10.0K), Bank Of America Corp /De/ (231).
Per Business Quant data, the top 10 holders of Xilio Therapeutics for the quarter ending December 2025 are Gilead Sciences, Inc. (9.11Mn), Bain Capital Life Sciences Investors, LLC (7.37Mn), Frazier Life Sciences Management, L.P. (5.92Mn), Point72 Asset Management, L.P. (4.0Mn), Sio Capital Management, LLC (2.13Mn), STEMPOINT CAPITAL LP (2.03Mn), Merck & Co., Inc. (1.48Mn), VANGUARD GROUP INC (1.26Mn), Empery Asset Management, LP (1.18Mn), Ghisallo Capital Management LLC (1.11Mn).

37 Institutional Holders

39,727,815 Total Shares Held

Rows:

Download Data

Owner Name	Date	Shares Held	Change (QoQ)	Change (%)	Value (USD)
Gilead Sciences, Inc.	31 Dec, 2025	9,105,451	0	0.00%	$5,829,310.00
Bain Capital Life Sciences Investors, LLC	31 Dec, 2025	7,372,686	2,805,869	61.44%	$4,719,994.00
Frazier Life Sciences Management, L.P.	31 Dec, 2025	5,915,091	5,915,091	0.00%	$3,786,841.00
Point72 Asset Management, L.P.	31 Dec, 2025	4,000,000	4,000,000	0.00%	$2,560,800.00
Sio Capital Management, LLC	31 Dec, 2025	2,134,537	2,134,537	0.00%	$1,366,531.00
STEMPOINT CAPITAL LP	31 Dec, 2025	2,030,028	2,030,028	0.00%	$1,299,624.00
Merck & Co., Inc.	31 Dec, 2025	1,483,758	0	0.00%	$949,902.00
VANGUARD GROUP INC	31 Dec, 2025	1,255,692	0	0.00%	$803,643.00
Empery Asset Management, LP	31 Dec, 2025	1,183,040	1,183,040	0.00%	$757,382.00
Ghisallo Capital Management LLC	31 Dec, 2025	1,113,222	1,113,222	0.00%	$712,685.00
Morgan Stanley	31 Dec, 2025	839,850	-122,067	-12.69%	$537,672.00
AJU IB Investment Co., Ltd.	31 Dec, 2025	667,742	0	0.00%	$427,488.00
FMR LLC	31 Dec, 2025	511,820	0	0.00%	$327,667.00
CITADEL ADVISORS LLC	31 Dec, 2025	436,216	436,216	0.00%	$279,265.00
RENAISSANCE TECHNOLOGIES LLC	31 Dec, 2025	344,416	139,716	68.25%	$220,495.00
GEODE CAPITAL MANAGEMENT, LLC	31 Dec, 2025	328,972	0	0.00%	$210,630.00
State Street Corp	31 Dec, 2025	186,390	22,500	13.73%	$119,327.00
Velan Capital Investment Management LP	31 Dec, 2025	170,000	170,000	0.00%	$108,834.00
GSA CAPITAL PARTNERS LLP	31 Dec, 2025	147,966	147,966	0.00%	$95.00
Stonepine Capital Management, LLC	31 Dec, 2025	126,270	126,270	0.00%	$80,838.00

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