Xeris Biopharma Holdings, Inc. (XERS) Institutional Ownership

Institutions by Trading Activity

Ownership Statistics

177,617,307Shares Outstanding

100,241,587Shares held by institutions

$614,480,928Value of institutional holdings

56.44%Institutional ownership %

5.12%Shares Changed QoQ

218No. of institutional investors

Shares Owned by Institutions

Shares Purchased/Sold by Institutions

Ownership Summary

Xeris Biopharma Holdings, Inc. (NASDAQ:XERS) is held by 218 institutional investors per 13F filings through December 2025.

Their combined ownership stood at 55.6% of outstanding shares in December 2025, down from 56.1% in September 2025.
Their total shares held in XERS increased 4.21% from the prior quarter, while the number of investors in Xeris Biopharma Holdings increased 36.25% year over year.
During the quarter, 111 of these 218 funds increased positions in XERS, 74 reduced exposure, and 33 held steady.
In total, institutional investors held 98.67Mn shares in Xeris Biopharma Holdings as of December 2025, up by 3.99Mn shares quarter on quarter, and up 26.39Mn shares year over year.
BlackRock, Inc. holds the largest position in XERS at 12.64Mn shares as of December 31, 2025, or 7.12% of shares outstanding.
Leading buyers of Xeris Biopharma Holdings shares for the quarter ending December 2025 were D. E. Shaw & Co., Inc. (1.73Mn), WELLINGTON MANAGEMENT GROUP LLP (1.71Mn), VANGUARD GROUP INC (1.36Mn), Goldman Sachs Group Inc (1.34Mn), Granahan Investment Management, LLC (873.24K).
The largest sales of XERS for the quarter ending December 2025 came from Bank Of America Corp /De/ (2.47Mn), UBS Group AG (1.18Mn), RENAISSANCE TECHNOLOGIES LLC (1.0Mn), Jpmorgan Chase & Co (915.09K), Prudential Financial Inc (815.26K).
Per Business Quant data, the top 10 holders of Xeris Biopharma Holdings for the quarter ending December 2025 are BlackRock, Inc. (12.64Mn), VANGUARD GROUP INC (11.19Mn), D. E. Shaw & Co., Inc. (7.57Mn), GEODE CAPITAL MANAGEMENT, LLC (4.28Mn), State Street Corp (4.12Mn), Qube Research & Technologies Ltd (3.5Mn), Goldman Sachs Group Inc (3.14Mn), DRIEHAUS CAPITAL MANAGEMENT LLC (2.98Mn), Nuveen, LLC (2.81Mn), Morgan Stanley (2.71Mn).

218 Institutional Holders

100,241,587 Total Shares Held

Rows:

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Owner Name	Date	Shares Held	Change (QoQ)	Change (%)	Value (USD)
BlackRock, Inc.	31 Dec, 2025	12,639,318	711,619	5.97%	$99,218,645.00
VANGUARD GROUP INC	31 Dec, 2025	11,186,677	1,358,760	13.83%	$87,815,416.00
D. E. Shaw & Co., Inc.	31 Dec, 2025	7,574,850	1,734,964	29.71%	$59,462,573.00
GEODE CAPITAL MANAGEMENT, LLC	31 Dec, 2025	4,275,989	135,815	3.28%	$33,571,396.00
State Street Corp	31 Dec, 2025	4,116,924	378,595	10.13%	$32,317,853.00
Qube Research & Technologies Ltd	31 Dec, 2025	3,498,197	223,363	6.82%	$27,460,846.00
Goldman Sachs Group Inc	31 Dec, 2025	3,136,842	1,341,387	74.71%	$24,624,210.00
DRIEHAUS CAPITAL MANAGEMENT LLC	31 Dec, 2025	2,980,567	361,438	13.80%	$23,397,451.00
Nuveen, LLC	31 Dec, 2025	2,806,806	-21,068	-0.75%	$22,033,428.00
Morgan Stanley	31 Dec, 2025	2,707,783	-511,918	-15.90%	$21,256,104.00
WELLINGTON MANAGEMENT GROUP LLP	31 Dec, 2025	2,286,598	1,705,636	293.59%	$17,949,794.00
Rosalind Advisors, Inc.	31 Dec, 2025	2,111,700	315,934	17.59%	$16,576,845.00
TWO SIGMA INVESTMENTS, LP	31 Dec, 2025	1,732,667	118,088	7.31%	$13,601,436.00
CHARLES SCHWAB INVESTMENT MANAGEMENT INC	31 Dec, 2025	1,403,824	-42,795	-2.96%	$11,020,018.00
Legal & General Group Plc	31 Dec, 2025	1,396,265	38,838	2.86%	$10,954,263.00
CenterBook Partners LP	31 Dec, 2025	1,391,590	693,386	99.31%	$10,923,982.00
Northern Trust Corp	31 Dec, 2025	1,386,829	23,700	1.74%	$10,886,607.00
Granahan Investment Management, LLC	31 Dec, 2025	1,223,404	873,236	249.38%	$9,603,721.00
KENNEDY CAPITAL MANAGEMENT LLC	31 Dec, 2025	1,213,969	2,386	0.20%	$9,529,657.00
Connor, Clark & Lunn Investment Management Ltd.	31 Dec, 2025	1,058,692	-640,065	-37.68%	$8,310,732.00

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