Vertex Pharmaceuticals Inc / Ma (VRTX) Institutional Ownership

Institutions by Trading Activity

Ownership Statistics

253,335,714Shares Outstanding

1,389,261Shares held by institutions

$663,122,061Value of institutional holdings

93.58%Institutional ownership %

10.20%Shares Changed QoQ

517No. of institutional investors

Shares Owned by Institutions

Shares Purchased/Sold by Institutions

Ownership Summary

Vertex Pharmaceuticals Inc / Ma (NASDAQ:VRTX) currently has 1562 active institutional owners and shareholders as of today (December 2025), that have filed 13F forms with the Securities Exchange Commission (SEC).

These investors collectively held 88.8% of the company's total shares outstanding in December 2025, down from 90.3% in September 2025.
On a quarter-over-quarter basis, institutional holdings shifted by 3.16%, with a year-over-year an increase of 2.49% in the count of filers.
Among the 1562 institutional holders of Vertex Pharmaceuticals, 825 added to their stakes while 535 trimmed their positions and 202 held steady.
This class of investors increased its holdings in Vertex Pharmaceuticals to 229.02Mn shares for the 13F-cycle ending December 2025, up by 7.01Mn shares quarter on quarter, and down 7.02Mn shares year over year.
Capital World Investors continues to be the largest institutional holder of Vertex Pharmaceuticals as of December 31, 2025, with a position of 25.51Mn shares, representing 9.89% of the company's outstanding stock.
Among the most significant buyers of Vertex Pharmaceuticals during December 2025 were NORGES BANK (3.18Mn), BlackRock, Inc. (1.50Mn), VICTORY CAPITAL MANAGEMENT INC (1.11Mn), Winslow Capital Management, LLC (887.64K), Capital Research Global Investors (763.06K).
Leading sellers of Vertex Pharmaceuticals stock in December 2025 included FMR LLC (1.09Mn), WELLINGTON MANAGEMENT GROUP LLP (950.31K), DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main (537.70K), EDGEWOOD MANAGEMENT LLC (427.47K), Capital World Investors (400.40K).
The top 10 institutional holders of Vertex Pharmaceuticals for the quarter ending December 2025 included Capital World Investors (25.51Mn), VANGUARD GROUP INC (24.11Mn), BlackRock, Inc. (23.75Mn), Capital Research Global Investors (17.32Mn), STATE STREET CORP (11.69Mn), JPMORGAN CHASE & CO (6.04Mn), GEODE CAPITAL MANAGEMENT, LLC (5.98Mn), Capital International Investors (4.73Mn), ALLIANCEBERNSTEIN L.P. (4.50Mn), LOOMIS SAYLES & CO L P (4.03Mn).

1,562 Institutional Holders

1,389,261 Total Shares Held

Rows:

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Owner Name	Date	Shares Held	Change (QoQ)	Change (%)	Value (USD)
Capital World Investors	31 Dec, 2025	25,510,182	-400,405	-1.55%	$11,565,309,006.00
VANGUARD GROUP INC	31 Dec, 2025	24,105,823	-111,042	-0.46%	$10,928,615,915.00
BlackRock, Inc.	31 Dec, 2025	23,751,989	1,498,942	6.74%	$10,768,201,653.00
Capital Research Global Investors	31 Dec, 2025	17,316,344	763,063	4.61%	$7,850,543,946.00
STATE STREET CORP	31 Dec, 2025	11,689,539	83,539	0.72%	$5,299,569,401.00
JPMORGAN CHASE & CO	31 Dec, 2025	6,039,481	-395,297	-6.14%	$2,738,059,237.00
GEODE CAPITAL MANAGEMENT, LLC	31 Dec, 2025	5,981,905	8,160	0.14%	$2,700,207,827.00
Capital International Investors	31 Dec, 2025	4,733,596	44,537	0.95%	$2,146,040,530.00
ALLIANCEBERNSTEIN L.P.	31 Dec, 2025	4,496,482	-26,104	-0.58%	$2,038,525,080.00
LOOMIS SAYLES & CO L P	31 Dec, 2025	4,033,525	-88,603	-2.15%	$1,828,638,685.00
WELLINGTON MANAGEMENT GROUP LLP	31 Dec, 2025	3,821,731	-950,311	-19.91%	$1,732,619,966.00
VICTORY CAPITAL MANAGEMENT INC	31 Dec, 2025	3,356,766	1,109,200	49.35%	$1,521,850,963.00
JENNISON ASSOCIATES LLC	31 Dec, 2025	3,249,541	-205,406	-5.95%	$1,473,211,801.00
NORGES BANK	31 Dec, 2025	3,176,613	3,176,613	0.00%	$1,440,149,270.00
MORGAN STANLEY	31 Dec, 2025	3,120,310	11,905	0.38%	$1,414,625,263.00
UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC	31 Dec, 2025	3,000,778	113,661	3.94%	$1,360,432,714.00
BANK OF AMERICA CORP /DE/	31 Dec, 2025	2,937,030	96,606	3.40%	$1,331,532,113.00
Clearbridge Investments, LLC	31 Dec, 2025	2,860,176	214,412	8.10%	$1,296,689,269.00
NORTHERN TRUST CORP	31 Dec, 2025	2,579,457	-48,430	-1.84%	$1,169,422,624.00
AMERIPRISE FINANCIAL INC	31 Dec, 2025	2,263,732	-13,195	-0.58%	$1,026,286,730.00

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