UroGen Pharma Ltd. (URGN) Institutional Ownership

Institutions by Trading Activity

Ownership Statistics

50,503,681Shares Outstanding

9,635,253Shares held by institutions

$198,486,212Value of institutional holdings

87.23%Institutional ownership %

10.79%Shares Changed QoQ

162No. of institutional investors

Shares Owned by Institutions

Shares Purchased/Sold by Institutions

Ownership Summary

Recent 13F filings as of December 2025 show that 162 institutional investors hold a position in UroGen Pharma Ltd. (NASDAQ:URGN).

The collective stake of institutional investors in UroGen Pharma moved to 87.2% in December 2025, a shift down from the 89.6% reported for September 2025.
On a quarter-over-quarter basis, institutional holdings shifted by 10.79%, with a year-over-year an increase of 18.25% in the count of filers.
A review of institutional activity for UroGen Pharma shows 79 of 162 filers increasing their positions, while 52 reduced their stake, and 31 remained unchanged.
Collectively, institutional investors increased their stake in UroGen Pharma to 44.05Mn shares as of December 2025, a change that is up by 4.29Mn shares quarter on quarter and up 7.83Mn shares year over year.
With 4.54Mn shares, RTW INVESTMENTS, LP commands the largest institutional position in UroGen Pharma as of December 31, 2025, equating to 9.00% of the company.
Among the most significant buyers of UroGen Pharma during December 2025 were AMERICAN CENTURY COMPANIES INC (1.36Mn), HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND (1.13Mn), MPM BioImpact LLC (806.38K), FRONTIER CAPITAL MANAGEMENT CO LLC (781.62K), SUPERSTRING CAPITAL MANAGEMENT LP (630.44K).
Leading sellers of UroGen Pharma stock in December 2025 included MILLENNIUM MANAGEMENT LLC (894.78K), TANG CAPITAL MANAGEMENT LLC (650.00K), Soleus Capital Management, L.P. (529.00K), JANE STREET GROUP, LLC (389.32K), JPMORGAN CHASE & CO (388.27K).
The top 10 institutional holders of UroGen Pharma for the quarter ending December 2025 included RTW INVESTMENTS, LP (4.54Mn), Paradigm Biocapital Advisors LP (4.47Mn), BlackRock, Inc. (2.60Mn), MORGAN STANLEY (2.56Mn), Jefferies Financial Group Inc. (2.20Mn), SILVERARC CAPITAL MANAGEMENT, LLC (1.74Mn), ACORN CAPITAL ADVISORS, LLC (1.45Mn), SG Americas Securities, LLC (1.38Mn), AMERICAN CENTURY COMPANIES INC (1.36Mn), MENORA MIVTACHIM HOLDINGS LTD. (1.15Mn).

162 Institutional Holders

9,635,253 Total Shares Held

Rows:

Download Data

Owner Name	Date	Shares Held	Change (QoQ)	Change (%)	Value (USD)
RTW INVESTMENTS, LP	31 Dec, 2025	4,543,895	0	0.00%	$106,418,021.00
Paradigm Biocapital Advisors LP	31 Dec, 2025	4,473,648	257,564	6.11%	$104,772,836.00
BlackRock, Inc.	31 Dec, 2025	2,601,009	19,723	0.76%	$60,915,631.00
MORGAN STANLEY	31 Dec, 2025	2,562,901	34,455	1.36%	$60,023,155.00
Jefferies Financial Group Inc.	31 Dec, 2025	2,199,652	0	0.00%	$51,515,850.00
SILVERARC CAPITAL MANAGEMENT, LLC	31 Dec, 2025	1,738,821	161,538	10.24%	$40,723,188.00
ACORN CAPITAL ADVISORS, LLC	31 Dec, 2025	1,448,420	188,671	14.98%	$33,921,996.00
SG Americas Securities, LLC	31 Dec, 2025	1,377,647	220,264	19.03%	$32,264.00
AMERICAN CENTURY COMPANIES INC	31 Dec, 2025	1,358,812	1,358,812	0.00%	$31,823,425.00
MENORA MIVTACHIM HOLDINGS LTD.	31 Dec, 2025	1,152,531	0	0.00%	$26,992,276.00
HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND	31 Dec, 2025	1,125,100	1,125,100	0.00%	$26,349,842.00
Caption Management, LLC	31 Dec, 2025	1,000,000	-70,000	-6.54%	$23,420,000.00
D. E. Shaw & Co., Inc.	31 Dec, 2025	962,624	73,691	8.29%	$22,544,654.00
MPM BioImpact LLC	31 Dec, 2025	941,378	806,378	597.32%	$22,047,073.00
ORBIMED ADVISORS LLC	31 Dec, 2025	875,487	186,487	27.07%	$20,503,906.00
STATE STREET CORP	31 Dec, 2025	807,421	-12,025	-1.47%	$18,909,800.00
FRONTIER CAPITAL MANAGEMENT CO LLC	31 Dec, 2025	781,620	781,620	0.00%	$18,305,546.00
Migdal Insurance & Financial Holdings Ltd.	31 Dec, 2025	770,909	0	0.00%	$18,055.00
CITADEL ADVISORS LLC	31 Dec, 2025	737,757	135,480	22.49%	$17,278,269.00
SUPERSTRING CAPITAL MANAGEMENT LP	31 Dec, 2025	718,354	630,442	717.13%	$16,823,851.00

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