As of August 29, 2026, the three largest insider holders of TVTX are Eric M Dube (Chief Executive Officer, 432.89K shares), Eric M Dube (Chief Executive Officer, 432.89K shares), Steve Aselage (Chief Executive Officer, 146.92K shares).
| # | Insider | Position | Direct | Indirect | Total | Share of Insiders | Last Filed |
|---|---|---|---|---|---|---|---|
| 1 | Eric M Dube | Chief Executive Officer | 432,886 | 0 | 432,886 | 25.9% | 06 May, 2026 |
| 2 | Steve Aselage | Chief Executive Officer | 146,919 | 0 | 146,919 | 8.8% | 12 May, 2022 |
| 3 | Peter Heerma | Chief Commercial Officer | 140,684 | 0 | 140,684 | 8.4% | 06 May, 2026 |
| 4 | Christopher R. Cline | Chief Financial Officer | 118,658 | 0 | 118,658 | 7.1% | 06 May, 2026 |
| 5 | William E. Rote | Chief Research Officer | 115,474 | 0 | 115,474 | 6.9% | 06 May, 2026 |
| 6 | Jula Inrig | Chief Medical Officer | 112,770 | 0 | 112,770 | 6.7% | 22 Jun, 2026 |
| 7 | Elizabeth E Reed | Chief Legal Officer And Gc | 105,211 | 0 | 105,211 | 6.3% | 06 May, 2026 |
| 8 | Jeffrey A Meckler | Director | 91,500 | 0 | 91,500 | 5.5% | 21 May, 2026 |
| 9 | Gary A Lyons | Director | 61,500 | 0 | 61,500 | 3.7% | 19 Aug, 2026 |
| 10 | Timothy Coughlin | Director | 56,250 | 0 | 56,250 | 3.4% | 16 Jun, 2026 |
| 11 | Sandra Calvin | Svp, Chief Accounting Officer | 42,353 | 0 | 42,353 | 2.5% | 16 Apr, 2026 |
| 12 | Roy D. Baynes | Director | 41,500 | 0 | 41,500 | 2.5% | 21 May, 2026 |
| 13 | John A Orwin | Director | 39,375 | 0 | 39,375 | 2.4% | 21 May, 2026 |
| 14 | Ron Squarer | Director | 39,375 | 0 | 39,375 | 2.4% | 21 May, 2026 |
| 15 | Laura Clague | Chief Financial Officer | 35,655 | 0 | 35,655 | 2.1% | 12 May, 2022 |
| 16 | Sandra Poole | Director | 34,000 | 0 | 34,000 | 2.0% | 21 May, 2026 |
| 17 | Brinkley Ruth Williams | Director | 29,750 | 0 | 29,750 | 1.8% | 21 May, 2026 |
| 18 | Suzanne Louise Bruhn | Director | 28,750 | 0 | 28,750 | 1.7% | 16 May, 2025 |
Each row is that insider’s most recently reported position, from Form 4 filings over the last 60 months — which is why this total does not tie to the quarterly series above, where a quarter counts only the insiders who filed in it. Shares held through a fund or institutional portfolio are counted on the institutional ownership page instead.
| Date | Insider | Position | Transaction | Shares | Price | Value | Shares Held After | Ownership |
|---|---|---|---|---|---|---|---|---|
| 17 Aug, 2026 | Gary A Lyons | Director | Acquired M | 5,000 | $17.44 | $87.20K | 66,500 | Direct |
| 17 Aug, 2026 | Gary A Lyons | Director | Disposed S | 1,900 | $62.53 | $118.80K | 64,600 | Direct |
| 17 Aug, 2026 | Gary A Lyons | Director | Disposed S | 2,600 | $63.50 | $165.10K | 62,000 | Direct |
| 17 Aug, 2026 | Gary A Lyons | Director | Disposed S | 500 | $64.16 | $32.08K | 61,500 | Direct |
| 18 Aug, 2026 | Gary A Lyons | Director | Acquired M | 5,000 | $17.44 | $87.20K | 66,500 | Direct |
| 18 Aug, 2026 | Gary A Lyons | Director | Disposed S | 4,100 | $63.27 | $259.39K | 62,400 | Direct |
| 18 Aug, 2026 | Gary A Lyons | Director | Disposed S | 900 | $63.86 | $57.47K | 61,500 | Direct |
| 17 Aug, 2026 | Gary A Lyons | Director | Disposed M | 5,000 | $0.00 | $0 | 5,000 | Direct |
| 18 Aug, 2026 | Gary A Lyons | Director | Disposed M | 5,000 | $0.00 | $0 | 0 | Direct |
| 22 Jun, 2026 | Jula Inrig | Chief Medical Officer | Disposed G | 468 | $0.00 | $0 | 112,770 | Direct |
| 12 Jun, 2026 | Timothy Coughlin | Director | Acquired M | 10,000 | $26.52 | $265.20K | 66,250 | Direct |
| 12 Jun, 2026 | Timothy Coughlin | Director | Disposed S | 10,000 | $50.07 | $500.75K | 56,250 | Direct |
| 12 Jun, 2026 | Timothy Coughlin | Director | Disposed M | 10,000 | $0.00 | $0 | 0 | Direct |
| 19 May, 2026 | Sandra Poole | Director | Acquired A | 4,000 | $0.00 | $0 | 34,000 | Direct |
| 19 May, 2026 | Jeffrey A Meckler | Director | Acquired A | 4,000 | $0.00 | $0 | 91,500 | Direct |
| 19 May, 2026 | Timothy Coughlin | Director | Acquired A | 4,000 | $0.00 | $0 | 56,250 | Direct |
| 19 May, 2026 | Gary A Lyons | Director | Acquired A | 4,000 | $0.00 | $0 | 61,500 | Direct |
| 19 May, 2026 | John A Orwin | Director | Acquired A | 4,000 | $0.00 | $0 | 39,375 | Direct |
| 19 May, 2026 | Ron Squarer | Director | Acquired A | 4,000 | $0.00 | $0 | 39,375 | Direct |
| 19 May, 2026 | Brinkley Ruth Williams | Director | Acquired A | 4,000 | $0.00 | $0 | 29,750 | Direct |