As of September 29, 2026, the three largest insider holders of TVTX are Eric M Dube (Chief Executive Officer, 432.89K shares), Steve Aselage (Chief Executive Officer, 146.92K shares), Peter Heerma (Evp, Chief Commercial Officer, 117.07K shares).
| # | Insider | Position | Direct | Indirect | Total | Share of Insiders | Last Filed |
|---|---|---|---|---|---|---|---|
| 1 | Eric M Dube | Chief Executive Officer | 432,886 | 0 | 432,886 | 27.2% | 17 Sep, 2026 |
| 2 | Steve Aselage | Chief Executive Officer | 146,919 | 0 | 146,919 | 9.2% | 12 May, 2022 |
| 3 | Peter Heerma | Evp, Chief Commercial Officer | 117,066 | 0 | 117,066 | 7.4% | 17 Sep, 2026 |
| 4 | Elizabeth E Reed | Chief Legal Officer And Gc | 105,389 | 0 | 105,389 | 6.6% | 17 Sep, 2026 |
| 5 | Jula Inrig | Evp, Head Of Rd Cmo | 100,491 | 0 | 100,491 | 6.3% | 17 Sep, 2026 |
| 6 | William E. Rote | Chief Research Officer | 98,197 | 0 | 98,197 | 6.2% | 17 Sep, 2026 |
| 7 | Jeffrey A Meckler | Director | 91,500 | 0 | 91,500 | 5.7% | 11 Sep, 2026 |
| 8 | Christopher R. Cline | Chief Financial Officer | 87,508 | 0 | 87,508 | 5.5% | 17 Sep, 2026 |
| 9 | Gary A Lyons | Director | 61,500 | 0 | 61,500 | 3.9% | 19 Aug, 2026 |
| 10 | Timothy Coughlin | Director | 56,250 | 0 | 56,250 | 3.5% | 16 Jun, 2026 |
| 11 | Sandra Calvin | Svp, Chief Accounting Officer | 42,353 | 0 | 42,353 | 2.7% | 17 Sep, 2026 |
| 12 | Roy D. Baynes | Director | 41,500 | 0 | 41,500 | 2.6% | 16 Jun, 2026 |
| 13 | John A Orwin | Director | 39,375 | 0 | 39,375 | 2.5% | 21 May, 2026 |
| 14 | Ron Squarer | Director | 39,375 | 0 | 39,375 | 2.5% | 21 May, 2026 |
| 15 | Laura Clague | Chief Financial Officer | 35,655 | 0 | 35,655 | 2.2% | 12 May, 2022 |
| 16 | Sandra Poole | Director | 34,000 | 0 | 34,000 | 2.1% | 21 May, 2026 |
| 17 | Suzanne Louise Bruhn | Director | 32,750 | 0 | 32,750 | 2.1% | 21 May, 2026 |
| 18 | Brinkley Ruth Williams | Director | 29,750 | 0 | 29,750 | 1.9% | 21 May, 2026 |
Each row is that insider’s most recently reported position, from Form 4 filings over the last 60 months — which is why this total does not tie to the quarterly series above, where a quarter counts only the insiders who filed in it. Shares held through a fund or institutional portfolio are counted on the institutional ownership page instead.
| Date | Insider | Position | Transaction | Shares | Price | Value | Shares Held After | Ownership |
|---|---|---|---|---|---|---|---|---|
| 15 Sep, 2026 | Sandra Calvin | Svp, Chief Accounting Officer | Acquired M | 2,500 | $27.50 | $68.75K | 44,853 | Direct |
| 15 Sep, 2026 | William E. Rote | Chief Research Officer | Acquired M | 39,000 | $25.25 | $984.75K | 154,745 | Direct |
| 15 Sep, 2026 | Peter Heerma | Evp, Chief Commercial Officer | Acquired M | 39,283 | $26.88 | $1.06Mn | 181,349 | Direct |
| 15 Sep, 2026 | Eric M Dube | Chief Executive Officer | Acquired M | 95,666 | $23.34 | $2.23Mn | 528,552 | Direct |
| 15 Sep, 2026 | Christopher R. Cline | Chief Financial Officer | Acquired M | 20,000 | $17.44 | $348.80K | 138,016 | Direct |
| 15 Sep, 2026 | Elizabeth E Reed | Chief Legal Officer And Gc | Acquired M | 37,500 | $15.46 | $579.75K | 142,889 | Direct |
| 15 Sep, 2026 | Jula Inrig | Evp, Head Of Rd Cmo | Acquired M | 32,395 | $8.93 | $289.29K | 145,165 | Direct |
| 15 Sep, 2026 | Eric M Dube | Chief Executive Officer | Disposed S | 63,498 | $61.99 | $3.94Mn | 465,054 | Direct |
| 15 Sep, 2026 | Peter Heerma | Evp, Chief Commercial Officer | Acquired M | 1,381 | $22.40 | $30.93K | 182,730 | Direct |
| 15 Sep, 2026 | Elizabeth E Reed | Chief Legal Officer And Gc | Disposed S | 21,926 | $62.03 | $1.36Mn | 120,963 | Direct |
| 15 Sep, 2026 | William E. Rote | Chief Research Officer | Acquired M | 39,650 | $17.96 | $712.11K | 194,395 | Direct |
| 15 Sep, 2026 | Christopher R. Cline | Chief Financial Officer | Disposed S | 27,473 | $62.00 | $1.70Mn | 110,543 | Direct |
| 15 Sep, 2026 | Jula Inrig | Evp, Head Of Rd Cmo | Disposed S | 25,390 | $62.02 | $1.57Mn | 119,775 | Direct |
| 15 Sep, 2026 | Sandra Calvin | Svp, Chief Accounting Officer | Acquired M | 1,250 | $22.40 | $28.00K | 46,103 | Direct |
| 15 Sep, 2026 | Christopher R. Cline | Chief Financial Officer | Disposed S | 20,735 | $62.61 | $1.30Mn | 89,808 | Direct |
| 15 Sep, 2026 | Jula Inrig | Evp, Head Of Rd Cmo | Disposed S | 17,284 | $62.62 | $1.08Mn | 102,491 | Direct |
| 15 Sep, 2026 | Elizabeth E Reed | Chief Legal Officer And Gc | Disposed S | 13,874 | $62.63 | $868.96K | 107,089 | Direct |
| 15 Sep, 2026 | Eric M Dube | Chief Executive Officer | Disposed S | 28,796 | $62.66 | $1.80Mn | 436,258 | Direct |
| 15 Sep, 2026 | Peter Heerma | Evp, Chief Commercial Officer | Acquired M | 36,526 | $8.93 | $326.18K | 219,256 | Direct |
| 15 Sep, 2026 | William E. Rote | Chief Research Officer | Disposed S | 63,907 | $61.99 | $3.96Mn | 130,488 | Direct |