Trevi Therapeutics, Inc. (TRVI) Institutional Ownership

Institutions by Trading Activity

Ownership Statistics

147,525,000Shares Outstanding

36,289,591Shares held by institutions

$368,339,349Value of institutional holdings

86.57%Institutional ownership %

-1.01%Shares Changed QoQ

178No. of institutional investors

Shares Owned by Institutions

Shares Purchased/Sold by Institutions

Ownership Summary

A total of 178 institutions have reported a stake in Trevi Therapeutics, Inc. (NASDAQ:TRVI) as of December 2025, according to recent 13F filings with the SEC.

These investors collectively held 86.6% of the company's total shares outstanding in December 2025, down from 89.3% in September 2025.
On a quarter-over-quarter basis, institutional holdings shifted by -1.01%, with a year-over-year an increase of 60.36% in the count of filers.
A review of institutional activity for Trevi Therapeutics shows 101 of 178 filers increasing their positions, while 50 reduced their stake, and 27 remained unchanged.
The total number of shares held by institutions in Trevi Therapeutics decreased to 127.71Mn as of December 2025, a net change of down by 1.30Mn shares quarter on quarter, and up 48.03Mn shares year over year.
As of December 31, 2025, NEA Management Company, LLC held Trevi Therapeutics's largest shareholding position with over 13.22Mn shares, representing 8.96% of total outstanding shares.
Among the most significant buyers of Trevi Therapeutics during December 2025 were FMR LLC (3.20Mn), EMERALD ADVISERS, LLC (1.89Mn), Pictet Asset Management Holding SA (1.52Mn), EMERALD MUTUAL FUND ADVISERS TRUST (1.27Mn), EVENTIDE ASSET MANAGEMENT, LLC (1.24Mn).
Leading sellers of Trevi Therapeutics stock in December 2025 included Rubric Capital Management LP (4.77Mn), MORGAN STANLEY (3.25Mn), Artia Global Partners LP (1.99Mn), VIKING GLOBAL INVESTORS LP (1.93Mn), ALLIANCEBERNSTEIN L.P. (1.21Mn).
The top 10 institutional holders of Trevi Therapeutics for the quarter ending December 2025 included NEA Management Company, LLC (13.22Mn), Frazier Life Sciences Management, L.P. (10.26Mn), BlackRock, Inc. (10.13Mn), FMR LLC (6.50Mn), VANGUARD GROUP INC (6.43Mn), Vivo Capital, LLC (5.09Mn), MARSHALL WACE, LLP (4.58Mn), Rubric Capital Management LP (3.77Mn), WELLINGTON MANAGEMENT GROUP LLP (3.40Mn), MPM BioImpact LLC (3.29Mn).

178 Institutional Holders

36,289,591 Total Shares Held

Rows:

Download Data

Owner Name	Date	Shares Held	Change (QoQ)	Change (%)	Value (USD)
NEA Management Company, LLC	31 Dec, 2025	13,222,228	0	0.00%	$165,542,295.00
Frazier Life Sciences Management, L.P.	31 Dec, 2025	10,259,409	0	0.00%	$128,447,801.00
BlackRock, Inc.	31 Dec, 2025	10,126,183	225,130	2.27%	$126,779,812.00
FMR LLC	31 Dec, 2025	6,500,009	3,200,118	96.98%	$81,380,117.00
VANGUARD GROUP INC	31 Dec, 2025	6,434,655	607,669	10.43%	$80,561,880.00
Vivo Capital, LLC	31 Dec, 2025	5,094,668	0	0.00%	$63,785,243.00
MARSHALL WACE, LLP	31 Dec, 2025	4,580,548	-261,203	-5.39%	$57,348,462.00
Rubric Capital Management LP	31 Dec, 2025	3,766,749	-4,765,111	-55.85%	$47,159,697.00
WELLINGTON MANAGEMENT GROUP LLP	31 Dec, 2025	3,403,990	150,102	4.61%	$42,617,956.00
MPM BioImpact LLC	31 Dec, 2025	3,287,087	-119,868	-3.52%	$41,154,329.00
VIKING GLOBAL INVESTORS LP	31 Dec, 2025	3,198,644	-1,930,231	-37.63%	$40,047,023.00
ORBIMED ADVISORS LLC	31 Dec, 2025	3,190,700	-117,700	-3.56%	$39,947,564.00
ALLIANCEBERNSTEIN L.P.	31 Dec, 2025	3,082,986	-1,209,465	-28.18%	$38,598,985.00
Octagon Capital Advisors LP	31 Dec, 2025	2,815,000	0	0.00%	$35,243,800.00
EVENTIDE ASSET MANAGEMENT, LLC	31 Dec, 2025	2,622,306	1,240,982	89.84%	$32,831,271.00
STATE STREET CORP	31 Dec, 2025	2,435,000	215,578	9.71%	$30,486,200.00
GEODE CAPITAL MANAGEMENT, LLC	31 Dec, 2025	2,412,885	191,959	8.64%	$30,214,388.00
Siren, L.L.C.	31 Dec, 2025	2,286,867	-250,000	-9.85%	$28,631,575.00
Affinity Asset Advisors, LLC	31 Dec, 2025	2,150,172	-649,828	-23.21%	$26,920,153.00
ACORN CAPITAL ADVISORS, LLC	31 Dec, 2025	2,144,844	0	0.00%	$26,853,447.00

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