Silence Therapeutics plc (SLN) Institutional Ownership

Ownership Summary

According to SEC filings for the period ending December 2025, Silence Therapeutics plc (NASDAQ:SLN) is held by 54 institutional firms.

• These investors collectively held 36.2% of the company's total shares outstanding in December 2025, down from 42.3% in September 2025.
• In percentage terms, this reflects as a holdings change of 0.87% quarter on quarter, and an unavailable change year over year.
• During the quarter, 27 institutions bought more Silence Therapeutics shares, 15 sold shares, and 12 of the 54 total investors held their position steady.
• The total number of shares held by institutions in Silence Therapeutics increased to 16.88Mn as of December 2025, a net change of up by 146.02K shares quarter on quarter, and down 1.85Mn shares year over year.
• With 3.03Mn shares, TCG Crossover Management, LLC commands the largest institutional position in Silence Therapeutics as of December 31, 2025, equating to 6.51% of the company.
• Among the most significant buyers of Silence Therapeutics during December 2025 were GREAT POINT PARTNERS LLC (808.03K), Nantahala Capital Management, LLC (500.00K), Tetragon Partners GP Ltd (365.37K), MILLENNIUM MANAGEMENT LLC (361.08K), Ishara Investments LP (240.00K).
• Leading sellers of Silence Therapeutics stock in December 2025 included Lombard Odier Asset Management (USA) Corp (1.59Mn), MORGAN STANLEY (883.09K), UBS Group AG (99.85K), BOOTHBAY FUND MANAGEMENT, LLC (70.55K), OSAIC HOLDINGS, INC. (62.17K).
• The top 10 institutional holders of Silence Therapeutics for the quarter ending December 2025 included TCG Crossover Management, LLC (3.03Mn), Siren, L.L.C. (2.91Mn), Redmile Group, LLC (2.16Mn), Nantahala Capital Management, LLC (1.54Mn), Vivo Capital, LLC (1.11Mn), Nextech Invest, Ltd. (952.40K), GREAT POINT PARTNERS LLC (808.03K), MILLENNIUM MANAGEMENT LLC (659.59K), 5AM Venture Management, LLC (476.20K), Tetragon Partners GP Ltd (365.37K).