Skye Bioscience, Inc. (SKYE) Institutional Ownership

Ownership Summary

The institutional landscape for Skye Bioscience, Inc. (NASDAQ:SKYE) includes 49 filers as of the latest reporting cycle ending December 2025.

• Skye Bioscience saw its institutional ownership percentage fell to 40.6% in December 2025 from 51.2% in September 2025.
• In percentage terms, this reflects as a holdings change of -6.59% quarter on quarter, and a decrease of 32.88% year over year.
• Of these 49 institutional investors, 19 increased their holdings in Skye Bioscience, while 11 of them reduced positions, and 19 investors maintained their exposure.
• The total number of shares held by institutions in Skye Bioscience decreased to 16.13Mn as of December 2025, a net change of down by 1.14Mn shares quarter on quarter, and down 9.08Mn shares year over year.
• 5AM Venture Management, LLC continues to be the largest institutional holder of Skye Bioscience as of December 31, 2025, with a position of 9.68Mn shares, representing 24.38% of the company's outstanding stock.
• Among the most significant buyers of Skye Bioscience during December 2025 were XTX Topco Ltd (53.04K), TWO SIGMA ADVISERS, LP (40.98K), HRT FINANCIAL LP (27.35K), Engineers Gate Manager LP (23.14K), GSA CAPITAL PARTNERS LLP (22.88K).
• Leading sellers of Skye Bioscience stock in December 2025 included Schonfeld Strategic Advisors LLC (1.19Mn), MILLENNIUM MANAGEMENT LLC (64.40K), TWO SIGMA INVESTMENTS, LP (40.61K), Zurcher Kantonalbank (Zurich Cantonalbank) (29.21K), UBS Group AG (16.70K).
• The top 10 institutional holders of Skye Bioscience for the quarter ending December 2025 included 5AM Venture Management, LLC (9.68Mn), Versant Venture Management, LLC (2.01Mn), BAKER BROS. ADVISORS LP (1.45Mn), VANGUARD GROUP INC (882.78K), SPHERA FUNDS MANAGEMENT LTD. (478.93K), MILLENNIUM MANAGEMENT LLC (380.48K), BlackRock, Inc. (281.84K), PLATINUM INVESTMENT MANAGEMENT LTD (233.09K), GEODE CAPITAL MANAGEMENT, LLC (210.15K), Schonfeld Strategic Advisors LLC (93.41K).