RPRX's three largest insider shareholders as of April 17, 2026 are 1978 Sicaf Sif S.A. Gg (TenPercentOwner, 22.08Mn shares), 1978 Sicaf Sif S.A. - Gg Strategic Gg (TenPercentOwner, 21.43Mn shares), Mario Germano Giuliani (Director, 7.80Mn shares).
| Holder | Position | Shares (Direct) | Shares (Indirect) | Report Date |
|---|---|---|---|---|
| 1978 Sicaf Sif S.A. Gg | - | 0 | 22,081,156 | 16 Sep, 2022 |
| 1978 Sicaf Sif S.A. - Gg Strategic Gg | - | 0 | 21,426,170 | 22 Sep, 2022 |
| Mario Germano Giuliani | - | 0 | 7,795,072 | 07 Dec, 2022 |
| Management Ltd Avara | - | 0 | 2,477,520 | 03 Jan, 2024 |
| Pablo G. Legorreta | Ceo, Chairman Of The Board | 1,098,783 | 0 | 13 Feb, 2026 |
| James F. Reddoch | Evp Chief Scientific Officer | 0 | 820,800 | 30 Sep, 2022 |
| Christopher Hite | Evp Vice Chairman | 0 | 685,136 | 13 Feb, 2026 |
| Pablo G. Legorreta | Ceo, Chairman Of The Board | 0 | 600,000 | 28 Jun, 2023 |
| George W. Lloyd | Evp, Investments Gc | 0 | 495,860 | 18 Nov, 2021 |
| Rory B Riggs | - | 320,099 | 0 | 22 Feb, 2024 |
| Gregory Norden | - | 194,848 | 0 | 11 Aug, 2025 |
| Rory B Riggs | - | 0 | 85,187 | 21 Mar, 2022 |
| Errol B Desouza | - | 81,352 | 0 | 14 May, 2025 |
| Terrance P. Coyne | Evp Cfo | 0 | 74,927 | 02 Apr, 2026 |
| Bonnie L Bassler | - | 73,947 | 0 | 31 Mar, 2026 |
| Henry A Fernandez | - | 65,324 | 0 | 30 Jun, 2025 |
| Henry A Fernandez | - | 0 | 58,200 | 25 Feb, 2022 |
| Ted W Love | - | 53,848 | 0 | 14 May, 2025 |
| Catherine M. Engelbert | - | 51,128 | 0 | 15 May, 2025 |
| David C Hodgson | - | 33,328 | 0 | 14 May, 2025 |
| Marshall Urist | Evp, Research Investments | 27,368 | 0 | 13 Feb, 2026 |
| Vlad Coric | - | 10,798 | 0 | 14 May, 2025 |
| Carole Ho | - | 8,558 | 0 | 31 Jul, 2025 |
| Elizabeth H Weatherman | - | 8,558 | 0 | 31 Jul, 2025 |
| Mario Germano Giuliani | - | 7,747 | 0 | 27 Jun, 2023 |
| George W. Lloyd | Evp, Investments Clo | 0 | 6,084 | 21 Nov, 2025 |
* Please note that the shares above only reflect shares from the fund portfolio and the institutional portfolio. Shares from the personal portfolio are excluded from this Institutional Ownership Page. See these insiders' latest transactions here on Insider Page.
| Transaction Date | Insider Name | Security Class | Transaction Type | Shares Traded | Price | Shares Remaining | Ownership | Code |
|---|---|---|---|---|---|---|---|---|
| 01 Apr, 2026 | Terrance P. Coyne | Class A Ordinary Shares | D | 1,875 | $48.33 | 42,011 | I | S |
| 01 Apr, 2026 | Terrance P. Coyne | Class A Ordinary Shares | D | 32,916 | $48.33 | 32,916 | I | S |
| 31 Mar, 2026 | Bonnie L Bassler | Class A Ordinary Shares | A | 815 | $45.98 | 73,947 | D | A |
| 23 Mar, 2026 | Terrance P. Coyne | Class A Ordinary Shares | D | 32,916 | $45.53 | 65,832 | I | S |
| 23 Mar, 2026 | Terrance P. Coyne | Class A Ordinary Shares | D | 1,875 | $45.53 | 43,886 | I | S |
| 02 Mar, 2026 | Terrance P. Coyne | Class A Ordinary Shares | D | 22,487 | $46.67 | 109,177 | I | S |
| 02 Mar, 2026 | Terrance P. Coyne | Class A Ordinary Shares | D | 10,429 | $47.01 | 98,748 | I | S |
| 02 Mar, 2026 | Terrance P. Coyne | Class A Ordinary Shares | D | 1,292 | $46.67 | 46,344 | I | S |
| 02 Mar, 2026 | Terrance P. Coyne | Class A Ordinary Shares | D | 583 | $47.01 | 45,761 | I | S |
| 23 Feb, 2026 | Terrance P. Coyne | Class A Ordinary Shares | D | 32,916 | $45.32 | 131,664 | I | S |
| 23 Feb, 2026 | Terrance P. Coyne | Class A Ordinary Shares | D | 1,875 | $45.32 | 47,636 | I | S |
| 11 Feb, 2026 | Christopher Hite | Class A Ordinary Shares | A | 26,626 | $0.00 | 685,136 | I | A |
| 11 Feb, 2026 | Marshall Urist | Class A Ordinary Shares | A | 19,970 | $0.00 | 27,368 | D | A |
| 11 Feb, 2026 | Terrance P. Coyne | Class A Ordinary Shares | A | 26,626 | $0.00 | 49,511 | I | A |
| 11 Feb, 2026 | Pablo G. Legorreta | Class A Ordinary Shares | A | 157,828 | $0.00 | 1,098,783 | D | A |
| 02 Feb, 2026 | Terrance P. Coyne | Class A Ordinary Shares | D | 102,581 | $42.08 | 292,415 | I | S |
| 03 Feb, 2026 | Terrance P. Coyne | Class A Ordinary Shares | D | 108,759 | $42.84 | 183,656 | I | S |
| 04 Feb, 2026 | Terrance P. Coyne | Class A Ordinary Shares | D | 19,076 | $43.29 | 164,580 | I | S |
| 02 Feb, 2026 | Terrance P. Coyne | Class A Ordinary Shares | D | 5,843 | $42.08 | 30,167 | I | S |
| 03 Feb, 2026 | Terrance P. Coyne | Class A Ordinary Shares | D | 6,195 | $42.84 | 23,972 | I | S |