Q32 Bio Inc. (QTTB) Institutional Ownership

Ownership Summary

According to SEC filings for the period ending December 2025, Q32 Bio Inc. (NASDAQ:QTTB) is held by 51 institutional firms.

• The percentage of Q32 Bio owned by institutions changed from 65.3% in September 2025 to 62.3% in December 2025, marking a slight down trend.
• In percentage terms, this reflects as a holdings change of -2.71% quarter on quarter, and a decrease of 44.57% year over year.
• A review of institutional activity for Q32 Bio shows 16 of 51 filers increasing their positions, while 20 reduced their stake, and 15 remained unchanged.
• The aggregate institutional position in Q32 Bio now stands at 8.04Mn shares as of December 2025, after investors decreased their holdings (down by 223.85K shares quarter on quarter which is down 2.99Mn shares year over year).
• As of December 31, 2025, ORBIMED ADVISORS LLC held Q32 Bio's largest shareholding position with over 2.25Mn shares, representing 17.45% of total outstanding shares.
• Among the most significant buyers of Q32 Bio during December 2025 were Opaleye Management Inc. (213.36K), RENAISSANCE TECHNOLOGIES LLC (52.30K), CITADEL ADVISORS LLC (35.61K), VANGUARD GROUP INC (25.64K), JANE STREET GROUP, LLC (25.37K).
• Leading sellers of Q32 Bio stock in December 2025 included ACORN CAPITAL ADVISORS, LLC (310.00K), Monaco Asset Management SAM (260.22K), MILLENNIUM MANAGEMENT LLC (53.50K), BlackRock, Inc. (33.07K), FMR LLC (12.50K).
• The top 10 institutional holders of Q32 Bio for the quarter ending December 2025 included ORBIMED ADVISORS LLC (2.25Mn), Atlas Venture Life Science Advisors, LLC (2.09Mn), Carlyle Group Inc. (1.10Mn), ACORN CAPITAL ADVISORS, LLC (493.43K), VANGUARD GROUP INC (321.05K), ARCH Venture Management, LLC (320.48K), PFIZER INC (277.78K), Sanofi (244.08K), Opaleye Management Inc. (213.36K), GEODE CAPITAL MANAGEMENT, LLC (106.11K).