Pyxis Oncology, Inc. (PYXS) Institutional Ownership

Ownership Summary

Recent 13F filings as of December 2025 show that 76 institutional investors hold a position in Pyxis Oncology, Inc. (NASDAQ:PYXS).

• Institutional ownership in Pyxis Oncology edged up to 47.9% in December 2025, compared to 42.6% in September 2025.
• Institutional share ownership changed by 42.75% QoQ, while the number of institutional owners saw a decrease of 24.00% YoY.
• A review of institutional activity for Pyxis Oncology shows 45 of 76 filers increasing their positions, while 18 reduced their stake, and 13 remained unchanged.
• The aggregate institutional position in Pyxis Oncology now stands at 30.13Mn shares as of December 2025, after investors increased their holdings (up by 9.02Mn shares quarter on quarter which is down 1.54Mn shares year over year).
• PFIZER INC continues to be the largest institutional holder of Pyxis Oncology as of December 31, 2025, with a position of 7.03Mn shares, representing 11.19% of the company's outstanding stock.
• Among the most significant buyers of Pyxis Oncology during December 2025 were GordonMD Global Investments LP (4.12Mn), Laurion Capital Management LP (1.17Mn), Atle Fund Management AB (617.25K), JANE STREET GROUP, LLC (482.31K), MARSHALL WACE, LLP (389.76K).
• Leading sellers of Pyxis Oncology stock in December 2025 included CITADEL ADVISORS LLC (93.77K), MILLENNIUM MANAGEMENT LLC (72.22K), GOLDMAN SACHS GROUP INC (39.31K), TWO SIGMA ADVISERS, LP (29.90K), SUSQUEHANNA INTERNATIONAL GROUP, LLP (29.12K).
• The top 10 institutional holders of Pyxis Oncology for the quarter ending December 2025 included PFIZER INC (7.03Mn), Laurion Capital Management LP (4.80Mn), GordonMD Global Investments LP (4.12Mn), VANGUARD GROUP INC (2.34Mn), Palo Alto Investors LP (1.04Mn), 683 Capital Management, LLC (891.91K), JANE STREET GROUP, LLC (786.01K), BlackRock, Inc. (784.08K), MILLENNIUM MANAGEMENT LLC (743.11K), RENAISSANCE TECHNOLOGIES LLC (728.38K).