Oruka Therapeutics, Inc. (ORKA) Institutional Ownership

Institutions by Trading Activity

Ownership Statistics

44,067,059Shares Outstanding

53,656,984Shares held by institutions

$3,432,437,266Value of institutional holdings

121.76%Institutional ownership %

19.26%Shares Changed QoQ

141No. of institutional investors

Shares Owned by Institutions

Shares Purchased/Sold by Institutions

Ownership Summary

Oruka Therapeutics, Inc. (NASDAQ:ORKA) is held by 141 institutional investors per 13F filings through December 2025.

These investors held 118.5% of outstanding shares in December 2025, up from 103.6% in September 2025.
They increased total shares held in Oruka Therapeutics by 16.32% from last quarter, and the number of investors in ORKA increased 113.64% annually.
Activity in ORKA broke down as 98 buyers, 18 sellers, and 25 unchanged among 141 total holders.
The aggregate institutional position in Oruka Therapeutics amounted to 52.23Mn shares as of December 2025, up by 7.33Mn shares quarter on quarter, and up 20.47Mn shares year over year.
MOODY ALDRICH PARTNERS LLC leads ownership in ORKA with 135.06K shares as of December 31, 2025, equal to 0.31% of outstanding shares.
Top purchasers of ORKA stock for the quarter ending December 2025 included MOODY ALDRICH PARTNERS LLC (8.25K), Abacus Wealth Partners, LLC (7.8K), E Fund Management Co., Ltd. (5.09K), PSP Research LLC (4.97K), GF FUND MANAGEMENT CO. LTD. (137).
The largest sellers of Oruka Therapeutics for the quarter ending December 2025 were Secure Asset Management, LLC (9.24K), Sterling Capital Management LLC (946), GAMMA Investing LLC (18).
Oruka Therapeutics's 10 largest shareholders as of December 2025 include MOODY ALDRICH PARTNERS LLC (135.06K), Secure Asset Management, LLC (72.42K), Abacus Wealth Partners, LLC (7.8K), E Fund Management Co., Ltd. (5.09K), PSP Research LLC (4.97K), Sterling Capital Management LLC (1.28K), GF FUND MANAGEMENT CO. LTD. (1.09K), Stone House Investment Management, LLC (1.0K), Activest Wealth Management (166), Versant Capital Management, Inc (98) per Business Quant data.

141 Institutional Holders

53,656,984 Total Shares Held

Rows:

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Owner Name	Date	Shares Held	Change (QoQ)	Change (%)	Value (USD)
FMR LLC	31 Dec, 2025	7,261,384	3,763	0.05%	$220,092,549.00
VR Adviser, LLC	31 Dec, 2025	4,148,428	0	0.00%	$125,738,853.00
Fairmount Funds Management LLC	31 Dec, 2025	3,705,262	0	0.00%	$112,306,491.00
BlackRock, Inc.	31 Dec, 2025	3,539,415	1,334,864	60.55%	$107,279,669.00
VIKING GLOBAL INVESTORS LP	31 Dec, 2025	2,666,690	0	0.00%	$80,827,374.00
Avoro Capital Advisors LLC	31 Dec, 2025	2,666,680	1,333,340	100.00%	$80,827,070.00
VANGUARD GROUP INC	31 Dec, 2025	2,453,530	676,865	38.10%	$74,366,494.00
Deep Track Capital, LP	31 Dec, 2025	2,161,510	-493,271	-18.58%	$65,515,368.00
RTW INVESTMENTS, LP	31 Dec, 2025	2,058,148	112,499	5.78%	$62,382,466.00
Commodore Capital LP	31 Dec, 2025	1,753,054	0	0.00%	$53,135,067.00
Paradigm Biocapital Advisors LP	31 Dec, 2025	1,710,316	1,710,316	0.00%	$51,839,678.00
Remedium Capital Partners, LLC	31 Dec, 2025	1,552,414	1,552,414	0.00%	$47,054.00
PERCEPTIVE ADVISORS LLC	31 Dec, 2025	1,476,501	208,480	16.44%	$44,752,745.00
State Street Corp	31 Dec, 2025	1,383,847	731,819	112.24%	$41,944,403.00
Blackstone Inc.	31 Dec, 2025	1,165,408	315,008	37.04%	$35,323,516.00
Polar Capital Holdings Plc	31 Dec, 2025	978,288	-54,019	-5.23%	$29,651,909.00
GEODE CAPITAL MANAGEMENT, LLC	31 Dec, 2025	942,507	252,535	36.60%	$28,574,387.00
Franklin Resources Inc	31 Dec, 2025	938,421	-127,361	-11.95%	$28,443,541.00
Affinity Asset Advisors, LLC	31 Dec, 2025	802,342	-156,838	-16.35%	$24,318,986.00
MERCER GLOBAL ADVISORS INC /ADV	31 Dec, 2025	745,277	-107,134	-12.57%	$22,589,346.00

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