According to SEC filings for the period ending December 2025, Orchestra BioMed Holdings, Inc. (NASDAQ:OBIO) is held by 1 institutional firms.
| Owner Name | Date | Shares Held | Change (QoQ) | Change (%) | Value (USD) |
|---|---|---|---|---|---|
| RTW INVESTMENTS, LP | 30 Sep, 2025 | 8,306,063 | 1 | 0.00% | $20,599,036.00 |
| PERCEPTIVE ADVISORS LLC | 30 Sep, 2025 | 5,292,556 | 700,000 | 15.24% | $13,125,539.00 |
| VANGUARD GROUP INC | 30 Sep, 2025 | 1,481,875 | 324,558 | 28.04% | $3,675,050.00 |
| Alyeska Investment Group, L.P. | 30 Sep, 2025 | 1,365,482 | 1,365,482 | 0.00% | $3,386,395.00 |
| Pathstone Holdings, LLC | 30 Sep, 2025 | 1,006,018 | 1,006,018 | 0.00% | $2,494,924.00 |
| Affinity Asset Advisors, LLC | 30 Sep, 2025 | 727,272 | 727,272 | 0.00% | $1,803,635.00 |
| BlackRock, Inc. | 30 Sep, 2025 | 664,333 | -17,016 | -2.50% | $1,647,546.00 |
| Knoll Capital Management, LLC | 30 Sep, 2025 | 455,128 | 0 | 0.00% | $421,163.00 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 30 Sep, 2025 | 421,612 | -16,757 | -3.82% | $1,046.00 |
| GEODE CAPITAL MANAGEMENT, LLC | 30 Sep, 2025 | 386,799 | 84,717 | 28.04% | $959,585.00 |
| RENAISSANCE TECHNOLOGIES LLC | 30 Sep, 2025 | 380,508 | 211,108 | 124.62% | $943,660.00 |
| MILLENNIUM MANAGEMENT LLC | 30 Sep, 2025 | 373,987 | -35,687 | -8.71% | $927,488.00 |
| DAFNA Capital Management LLC | 30 Sep, 2025 | 363,636 | 363,636 | 0.00% | $901,817.00 |
| Knott David M Jr | 30 Sep, 2025 | 195,000 | 95,000 | 95.00% | $483,600.00 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 30 Sep, 2025 | 180,439 | 41,848 | 30.20% | $447,489.00 |
| AMH Equity Ltd | 30 Sep, 2025 | 166,000 | 166,000 | 0.00% | $411,680.00 |
| NORTHERN TRUST CORP | 30 Sep, 2025 | 102,572 | 2,137 | 2.13% | $254,379.00 |
| STATE STREET CORP | 30 Sep, 2025 | 100,733 | -29,400 | -22.59% | $249,818.00 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 30 Sep, 2025 | 98,105 | -20,453 | -17.25% | $243,300.00 |
| TD ASSET MANAGEMENT INC | 30 Sep, 2025 | 92,678 | 0 | 0.00% | $229,841.00 |