As of August 29, 2026, the three largest insider holders of OBIO are Investments, Lp Rtw (TenPercentOwner, 9.56Mn shares), Investments, Lp Rtw (TenPercentOwner, 8.31Mn shares), Advisors Llc Perceptive (TenPercentOwner, 5.29Mn shares).
| # | Insider | Position | Direct | Indirect | Total | Share of Insiders | Last Filed |
|---|---|---|---|---|---|---|---|
| 1 | Investments, Lp Rtw | TenPercentOwner | 0 | 9,556,063 | 9,556,063 | 29.4% | 29 Apr, 2026 |
| 2 | Advisors Llc Perceptive | TenPercentOwner | 0 | 5,292,556 | 5,292,556 | 16.3% | 05 Aug, 2025 |
| 3 | Plc Medtronic | TenPercentOwner | 0 | 4,999,423 | 4,999,423 | 15.4% | 01 Feb, 2023 |
| 4 | Roderick Wong | Chief Executive Officer | 0 | 2,808,512 | 2,808,512 | 8.6% | 26 Jan, 2023 |
| 5 | Darren Sherman | Director, Officer | 2,303,729 | 2,000 | 2,305,729 | 7.1% | 28 Aug, 2026 |
| 6 | 2 Holdings, Llc Hsac | TenPercentOwner | 1,705,705 | 0 | 1,705,705 | 5.2% | 07 Aug, 2024 |
| 7 | Geoffrey Wade Smith | Director | 24,401 | 1,507,166 | 1,531,567 | 4.7% | 24 Jul, 2023 |
| 8 | David P Hochman | Director, Officer | 1,060,746 | 436,199 | 1,496,945 | 4.6% | 12 Jun, 2026 |
| 9 | Andrew Lawrence Taylor | Chief Financial Officer | 1,070,777 | 0 | 1,070,777 | 3.3% | 28 Aug, 2026 |
| 10 | Eric S Fain | Director | 0 | 313,441 | 313,441 | 1.0% | 14 Aug, 2026 |
| 11 | William Reed Little | Officer | 307,859 | 0 | 307,859 | 0.9% | 03 Jun, 2024 |
| 12 | Jason Aryeh | Director | 225,600 | 0 | 225,600 | 0.7% | 20 May, 2026 |
| 13 | John Prosper Mack | Director | 212,912 | 0 | 212,912 | 0.7% | 14 Aug, 2026 |
| 14 | David Pacitti | Director | 175,556 | 0 | 175,556 | 0.5% | 14 Aug, 2026 |
| 15 | Michael Kaswan | Chief Financial Officer | 162,574 | 0 | 162,574 | 0.5% | 05 May, 2023 |
| 16 | Yuval Mika | Officer | 158,905 | 0 | 158,905 | 0.5% | 10 May, 2024 |
| 17 | Chris Cleary | Director | 66,054 | 0 | 66,054 | 0.2% | 14 Aug, 2026 |
| 18 | Pamela Ann Connealy | Director | 66,038 | 0 | 66,038 | 0.2% | 25 Jun, 2026 |
| 19 | George Papandreou | Officer | 42,000 | 0 | 42,000 | 0.1% | 10 May, 2024 |
| 20 | Joshua Aiello | Principal Accounting Officer | 37,085 | 0 | 37,085 | 0.1% | 28 Aug, 2026 |
| 21 | Eric A Md Rose | Director | 9,712 | 0 | 9,712 | 0.0% | 21 Jun, 2024 |
Each row is that insider’s most recently reported position, from Form 4 filings over the last 60 months — which is why this total does not tie to the quarterly series above, where a quarter counts only the insiders who filed in it. Shares held through a fund or institutional portfolio are counted on the institutional ownership page instead.
| Date | Insider | Position | Transaction | Shares | Price | Value | Shares Held After | Ownership |
|---|---|---|---|---|---|---|---|---|
| 26 Aug, 2026 | Darren Sherman | Director, Officer | Disposed F | 4,925 | $5.26 | $25.91K | 1,149,402 | Direct |
| 26 Aug, 2026 | Andrew Lawrence Taylor | Chief Financial Officer | Disposed F | 3,076 | $5.26 | $16.18K | 589,989 | Direct |
| 26 Aug, 2026 | Joshua Aiello | Principal Accounting Officer | Disposed F | 203 | $5.26 | $1.07K | 18,441 | Direct |
| 26 Aug, 2026 | Darren Sherman | Director, Officer | Acquired P | 2,000 | $5.33 | $10.66K | 2,000 | Indirect |
| 12 Aug, 2026 | Eric S Fain | Director | Disposed F | 5,145 | $4.42 | $22.74K | 99,630 | Indirect |
| 12 Aug, 2026 | David Pacitti | Director | Disposed F | 3,761 | $4.42 | $16.62K | 54,750 | Direct |
| 12 Aug, 2026 | Chris Cleary | Director | Disposed F | 4,238 | $4.42 | $18.73K | 29,153 | Direct |
| 12 Aug, 2026 | John Prosper Mack | Director | Disposed F | 4,885 | $4.42 | $21.59K | 66,544 | Direct |
| 03 Aug, 2026 | Darren Sherman | Director, Officer | Disposed S | 15,000 | $4.09 | $61.35K | 1,154,327 | Direct |
| 01 Jul, 2026 | Darren Sherman | Director, Officer | Disposed S | 15,000 | $4.27 | $64.05K | 1,169,327 | Direct |
| 23 Jun, 2026 | Pamela Ann Connealy | Director | Acquired A | 17,327 | $0.00 | $0 | 66,038 | Direct |
| 24 Jun, 2026 | Chris Cleary | Director | Disposed F | 3,510 | $0.00 | $0 | 33,391 | Direct |
| 23 Jun, 2026 | Jason Aryeh | Director | Acquired A | 42,553 | $0.00 | $0 | 42,553 | Direct |
| 23 Jun, 2026 | David Pacitti | Director | Acquired A | 17,327 | $0.00 | $0 | 62,295 | Direct |
| 23 Jun, 2026 | John Prosper Mack | Director | Acquired A | 34,653 | $0.00 | $0 | 74,939 | Direct |
| 23 Jun, 2026 | Eric S Fain | Director | Acquired A | 17,327 | $0.00 | $0 | 109,036 | Indirect |
| 23 Jun, 2026 | Chris Cleary | Director | Acquired A | 42,553 | $0.00 | $0 | 42,553 | Direct |
| 23 Jun, 2026 | Pamela Ann Connealy | Director | Acquired A | 21,277 | $0.00 | $0 | 21,277 | Direct |
| 24 Jun, 2026 | David Pacitti | Director | Disposed F | 3,784 | $0.00 | $0 | 58,511 | Direct |
| 24 Jun, 2026 | Eric S Fain | Director | Disposed F | 4,261 | $0.00 | $0 | 104,775 | Indirect |