Disc Medicine, Inc. (IRON) Institutional Ownership

Institutions by Trading Activity

Ownership Statistics

33,852,336Shares Outstanding

747,518Shares held by institutions

$49,014,755Value of institutional holdings

107.22%Institutional ownership %

16.56%Shares Changed QoQ

190No. of institutional investors

Shares Owned by Institutions

Shares Purchased/Sold by Institutions

Ownership Summary

The institutional landscape for Disc Medicine, Inc. (NASDAQ:IRON) includes 190 filers as of the latest reporting cycle ending December 2025.

The collective stake of institutional investors in Disc Medicine moved to 107.2% in December 2025, a shift up from the 101.1% reported for September 2025.
On a quarter-over-quarter basis, institutional holdings shifted by 16.56%, with a year-over-year an increase of 25.83% in the count of filers.
A review of institutional activity for Disc Medicine shows 123 of 190 filers increasing their positions, while 48 reduced their stake, and 19 remained unchanged.
Collectively, institutional investors increased their stake in Disc Medicine to 36.30Mn shares as of December 2025, a change that is up by 5.16Mn shares quarter on quarter and up 9.83Mn shares year over year.
With 5.45Mn shares, FMR LLC commands the largest institutional position in Disc Medicine as of December 31, 2025, equating to 16.10% of the company.
Among the most significant buyers of Disc Medicine during December 2025 were JPMORGAN CHASE & CO (828.25K), BVF INC/IL (650.00K), JENNISON ASSOCIATES LLC (532.08K), FMR LLC (515.06K), PERCEPTIVE ADVISORS LLC (450.74K).
Leading sellers of Disc Medicine stock in December 2025 included Atlas Venture Life Science Advisors, LLC (628.74K), DEERFIELD MANAGEMENT COMPANY, L.P. (408.24K), JANUS HENDERSON GROUP PLC (350.15K), ORBIMED ADVISORS LLC (347.47K), First Turn Management, LLC (244.49K).
The top 10 institutional holders of Disc Medicine for the quarter ending December 2025 included FMR LLC (5.45Mn), BlackRock, Inc. (2.27Mn), RA CAPITAL MANAGEMENT, L.P. (1.98Mn), VANGUARD GROUP INC (1.77Mn), JPMORGAN CHASE & CO (1.58Mn), WELLINGTON MANAGEMENT GROUP LLP (1.52Mn), Atlas Venture Life Science Advisors, LLC (1.51Mn), Frazier Life Sciences Management, L.P. (1.26Mn), STATE STREET CORP (1.19Mn), ORBIMED ADVISORS LLC (1.07Mn).

190 Institutional Holders

747,518 Total Shares Held

Rows:

Download Data

Owner Name	Date	Shares Held	Change (QoQ)	Change (%)	Value (USD)
FMR LLC	31 Dec, 2025	5,450,222	515,063	10.44%	$432,802,132.00
BlackRock, Inc.	31 Dec, 2025	2,274,980	255,697	12.66%	$180,656,161.00
RA CAPITAL MANAGEMENT, L.P.	31 Dec, 2025	1,976,132	399,026	25.30%	$156,924,642.00
VANGUARD GROUP INC	31 Dec, 2025	1,767,680	319,621	22.07%	$140,371,470.00
JPMORGAN CHASE & CO	31 Dec, 2025	1,581,127	828,248	110.01%	$125,557,326.00
WELLINGTON MANAGEMENT GROUP LLP	31 Dec, 2025	1,518,274	108,197	7.67%	$120,566,138.00
Atlas Venture Life Science Advisors, LLC	31 Dec, 2025	1,513,875	-628,742	-29.34%	$120,216,814.00
Frazier Life Sciences Management, L.P.	31 Dec, 2025	1,260,000	-178,534	-12.41%	$100,056,600.00
STATE STREET CORP	31 Dec, 2025	1,187,991	142,394	13.62%	$94,338,365.00
ORBIMED ADVISORS LLC	31 Dec, 2025	1,067,550	-347,470	-24.56%	$84,774,146.00
Siren, L.L.C.	31 Dec, 2025	988,401	75,000	8.21%	$78,488,923.00
Woodline Partners LP	31 Dec, 2025	957,833	90,878	10.48%	$76,061,519.00
GOLDMAN SACHS GROUP INC	31 Dec, 2025	754,195	225,114	42.55%	$59,890,625.00
Vestal Point Capital, LP	31 Dec, 2025	735,000	235,000	47.00%	$58,366,350.00
GEODE CAPITAL MANAGEMENT, LLC	31 Dec, 2025	684,958	56,807	9.04%	$54,402,165.00
BVF INC/IL	31 Dec, 2025	650,000	650,000	0.00%	$51,616,500.00
JENNISON ASSOCIATES LLC	31 Dec, 2025	532,079	532,079	0.00%	$42,252,392.00
First Light Asset Management, LLC	31 Dec, 2025	523,167	291,981	126.30%	$41,544,691.00
DEERFIELD MANAGEMENT COMPANY, L.P.	31 Dec, 2025	511,163	-408,240	-44.40%	$40,591,454.00
Logos Global Management LP	31 Dec, 2025	510,000	60,000	13.33%	$40,499,100.00

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