Disc Medicine, Inc. (IRON) Institutional Ownership

Institutions by Trading Activity

Ownership Statistics

35,178,691Shares Outstanding

37,361,349Shares held by institutions

$2,602,965,185Value of institutional holdings

106.20%Institutional ownership %

15.52%Shares Changed QoQ

192No. of institutional investors

Shares Owned by Institutions

Shares Purchased/Sold by Institutions

Ownership Summary

Disc Medicine, Inc. (NASDAQ:IRON) has 192 institutional investors with active 13F positions as of December 2025.

They owned 103.5% of outstanding stock in December 2025, up from 100.1% the prior quarter.
Their total shares held in IRON increased 13.09% from the prior quarter, while the number of investors in Disc Medicine increased 28.0% year over year.
Activity in IRON broke down as 125 buyers, 48 sellers, and 19 unchanged among 192 total holders.
In total, institutional investors held 36.41Mn shares in Disc Medicine as of December 2025, up by 4.21Mn shares quarter on quarter, and up 9.56Mn shares year over year.
Assenagon Asset Management S.A. is the top holder of Disc Medicine as of December 31, 2025, with 546.25K shares representing 1.55% of outstanding stock.
The biggest buyers of Disc Medicine for the quarter ending December 2025 included Assenagon Asset Management S.A. (188.41K), PSP Research LLC (8.0K), E Fund Management Co., Ltd. (6.77K), Eleva Capital SAS (5.12K), Bayforest Capital Ltd (3.56K).
The largest sellers of Disc Medicine for the quarter ending December 2025 were SG Americas Securities, LLC (9.9K), Pictet Asset Management Holding SA (7.37K), iA Global Asset Management Inc. (187), GAMMA Investing LLC (36), Farther Finance Advisors, LLC (9).
Business Quant data shows the 10 biggest positions in Disc Medicine as of December 2025 are held by Assenagon Asset Management S.A. (546.25K), Pictet Asset Management Holding SA (387.0K), iA Global Asset Management Inc. (66.24K), SG Americas Securities, LLC (11.23K), PSP Research LLC (8.0K), E Fund Management Co., Ltd. (6.77K), STRS OHIO (6.0K), Eleva Capital SAS (5.12K), Bayforest Capital Ltd (3.56K), GF FUND MANAGEMENT CO. LTD. (848).

192 Institutional Holders

37,361,349 Total Shares Held

Rows:

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Owner Name	Date	Shares Held	Change (QoQ)	Change (%)	Value (USD)
FMR LLC	31 Dec, 2025	5,450,222	515,063	10.44%	$432,802,132.00
BlackRock, Inc.	31 Dec, 2025	2,274,980	255,697	12.66%	$180,656,161.00
RA CAPITAL MANAGEMENT, L.P.	31 Dec, 2025	1,976,132	399,026	25.30%	$156,924,642.00
VANGUARD GROUP INC	31 Dec, 2025	1,767,680	319,621	22.07%	$140,371,470.00
Jpmorgan Chase & Co	31 Dec, 2025	1,581,127	75,369	5.01%	$125,557,326.00
WELLINGTON MANAGEMENT GROUP LLP	31 Dec, 2025	1,518,274	108,197	7.67%	$120,566,138.00
Atlas Venture Life Science Advisors, LLC	31 Dec, 2025	1,513,875	-628,742	-29.34%	$120,216,814.00
Goldman Sachs Group Inc	31 Dec, 2025	1,508,390	979,309	185.10%	$119,781,250.00
Frazier Life Sciences Management, L.P.	31 Dec, 2025	1,260,000	-178,534	-12.41%	$100,056,600.00
State Street Corp	31 Dec, 2025	1,187,991	142,394	13.62%	$94,338,365.00
ORBIMED ADVISORS LLC	31 Dec, 2025	1,067,550	-347,470	-24.56%	$84,774,146.00
Siren, L.L.C.	31 Dec, 2025	988,401	75,000	8.21%	$78,488,923.00
Woodline Partners LP	31 Dec, 2025	957,833	90,878	10.48%	$76,061,519.00
Vestal Point Capital, LP	31 Dec, 2025	735,000	235,000	47.00%	$58,366,350.00
GEODE CAPITAL MANAGEMENT, LLC	31 Dec, 2025	684,958	56,807	9.04%	$54,402,165.00
BVF INC/IL	31 Dec, 2025	650,000	650,000	0.00%	$51,616,500.00
JENNISON ASSOCIATES LLC	31 Dec, 2025	532,079	532,079	0.00%	$42,252,392.00
First Light Asset Management, LLC	31 Dec, 2025	523,167	291,981	126.30%	$41,544,691.00
DEERFIELD MANAGEMENT COMPANY, L.P.	31 Dec, 2025	511,163	-408,240	-44.40%	$40,591,454.00
Logos Global Management LP	31 Dec, 2025	510,000	60,000	13.33%	$40,499,100.00

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