Inspire Medical Systems, Inc. (INSP) Institutional Ownership

Ownership Summary

Inspire Medical Systems, Inc. (NYSE:INSP) has 333 institutional investors that have filed 13F reports for the period ending December 2025.

• These investors held 118.5% of outstanding shares in December 2025, up from 106.3% in September 2025.
• Their total shares held in INSP increased 23.25% quarter over quarter, and separately, investors owning Inspire Medical Systems decreased 5.4% from a year ago.
• Activity in INSP broke down as 202 buyers, 111 sellers, and 20 unchanged among 333 total holders.
• Combined, these investors held 35.27Mn shares in INSP for December 2025, up by 6.65Mn shares quarter on quarter, and up 193.69K shares year over year.
• As of December 31, 2025, BlackRock, Inc. held the largest stake in Inspire Medical Systems with 3.55Mn shares, accounting for 11.93% of total shares outstanding.
• Top purchasers of INSP stock for the quarter ending December 2025 included VANGUARD PORTFOLIO MANAGEMENT LLC (1.64Mn), VANGUARD CAPITAL MANAGEMENT LLC (1.27Mn), DEERFIELD MANAGEMENT COMPANY, L.P. (1.2Mn), Vestal Point Capital, LP (539.27K), ADAR1 Capital Management, LLC (375.2K).
• The largest sellers of Inspire Medical Systems for the quarter ending December 2025 were Janus Henderson Group Plc (535.43K), Jain Global LLC (253.45K), Franklin Resources Inc (188.21K), Invesco Ltd. (157.4K), BNP PARIBAS FINANCIAL MARKETS (135.05K).
• Business Quant data shows the 10 biggest positions in Inspire Medical Systems as of December 2025 are held by BlackRock, Inc. (3.55Mn), DEERFIELD MANAGEMENT COMPANY, L.P. (2.7Mn), WELLINGTON MANAGEMENT GROUP LLP (2.54Mn), VANGUARD PORTFOLIO MANAGEMENT LLC (1.64Mn), Morgan Stanley (1.45Mn), VANGUARD CAPITAL MANAGEMENT LLC (1.27Mn), D. E. Shaw & Co., Inc. (1.19Mn), WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC (1.14Mn), State Street Corp (956.01K), Artisan Partners Limited Partnership (780.58K).