Heron Therapeutics, Inc. /De/ (HRTX) Institutional Ownership

Institutions by Trading Activity

Ownership Statistics

150,866,667Shares Outstanding

14,779,734Shares held by institutions

$17,587,883Value of institutional holdings

103.53%Institutional ownership %

5.95%Shares Changed QoQ

165No. of institutional investors

Shares Owned by Institutions

Shares Purchased/Sold by Institutions

Ownership Summary

The institutional landscape for Heron Therapeutics, Inc. /De/ (NASDAQ:HRTX) includes 165 filers as of the latest reporting cycle ending December 2025.

The collective stake of institutional investors in Heron Therapeutics moved to 103.5% in December 2025, a shift up from the 102.5% reported for September 2025.
Institutional share ownership changed by 5.95% QoQ, while the number of institutional owners saw an increase of 3.77% YoY.
During the quarter, 78 institutions bought more Heron Therapeutics shares, 42 sold shares, and 45 of the 165 total investors held their position steady.
The aggregate institutional position in Heron Therapeutics now stands at 156.20Mn shares as of December 2025, after investors increased their holdings (up by 8.77Mn shares quarter on quarter which is up 41.32Mn shares year over year).
Rubric Capital Management LP's holding of 30.05Mn shares as of December 31, 2025 makes it the primary institutional investor in Heron Therapeutics, owning 19.92% of the stock.
Among the most significant buyers of Heron Therapeutics during December 2025 were MILLENNIUM MANAGEMENT LLC (6.92Mn), TANG CAPITAL MANAGEMENT LLC (2.80Mn), Clearline Capital LP (2.52Mn), VANGUARD GROUP INC (1.36Mn), JANE STREET GROUP, LLC (1.14Mn).
Leading sellers of Heron Therapeutics stock in December 2025 included CITIGROUP INC (2.47Mn), Caption Management, LLC (2.40Mn), AQR CAPITAL MANAGEMENT LLC (1.56Mn), MORGAN STANLEY (1.50Mn), JPMORGAN CHASE & CO (1.23Mn).
The top 10 institutional holders of Heron Therapeutics for the quarter ending December 2025 included Rubric Capital Management LP (30.05Mn), Clearline Capital LP (12.24Mn), ADAGE CAPITAL PARTNERS GP, L.L.C. (11.19Mn), BlackRock, Inc. (10.22Mn), VANGUARD GROUP INC (9.82Mn), Velan Capital Investment Management LP (8.75Mn), MILLENNIUM MANAGEMENT LLC (7.17Mn), PALISADE CAPITAL MANAGEMENT, LP (6.33Mn), TANG CAPITAL MANAGEMENT LLC (6.25Mn), Tejara Capital Ltd (5.13Mn).

165 Institutional Holders

14,779,734 Total Shares Held

Rows:

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Owner Name	Date	Shares Held	Change (QoQ)	Change (%)	Value (USD)
Rubric Capital Management LP	31 Dec, 2025	30,046,828	946,100	3.25%	$39,060,876.00
Clearline Capital LP	31 Dec, 2025	12,235,239	2,522,712	25.97%	$15,905,811.00
ADAGE CAPITAL PARTNERS GP, L.L.C.	31 Dec, 2025	11,185,325	946,100	9.24%	$14,540,923.00
BlackRock, Inc.	31 Dec, 2025	10,218,236	230,776	2.31%	$13,283,708.00
VANGUARD GROUP INC	31 Dec, 2025	9,820,384	1,360,600	16.08%	$12,766,499.00
Velan Capital Investment Management LP	31 Dec, 2025	8,753,290	0	0.00%	$11,379,277.00
MILLENNIUM MANAGEMENT LLC	31 Dec, 2025	7,169,908	6,921,405	2,785.24%	$9,320,880.00
PALISADE CAPITAL MANAGEMENT, LP	31 Dec, 2025	6,326,113	-1,001,334	-13.67%	$8,223,947.00
TANG CAPITAL MANAGEMENT LLC	31 Dec, 2025	6,250,000	2,800,000	81.16%	$8,125,000.00
Tejara Capital Ltd	31 Dec, 2025	5,131,426	541,711	11.80%	$6,670,854.00
GEODE CAPITAL MANAGEMENT, LLC	31 Dec, 2025	4,081,222	438,240	12.03%	$5,306,435.00
STATE STREET CORP	31 Dec, 2025	3,778,043	126,540	3.47%	$4,911,456.00
JW Asset Management, LLC	31 Dec, 2025	3,671,073	378,440	11.49%	$4,772,395.00
Congress Park Capital LLC	31 Dec, 2025	3,067,475	177,318	6.14%	$3,987,718.00
D. E. Shaw & Co., Inc.	31 Dec, 2025	3,004,640	-83,852	-2.71%	$3,906,032.00
NEW YORK STATE COMMON RETIREMENT FUND	31 Dec, 2025	2,576,716	0	0.00%	$3,349,731.00
CITADEL ADVISORS LLC	31 Dec, 2025	2,095,045	-613,412	-22.65%	$2,723,559.00
UBS Group AG	31 Dec, 2025	2,091,669	-842,412	-28.71%	$2,719,170.00
RENAISSANCE TECHNOLOGIES LLC	31 Dec, 2025	1,915,900	-939,099	-32.89%	$2,490,670.00
Pale Fire Capital SE	31 Dec, 2025	1,469,655	998,465	211.90%	$1,910,552.00

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