Fulcrum Therapeutics, Inc. (FULC) Institutional Ownership

Institutions by Trading Activity

Ownership Statistics

62,380,702Shares Outstanding

5,984,410Shares held by institutions

$63,793,811Value of institutional holdings

105.28%Institutional ownership %

27.13%Shares Changed QoQ

164No. of institutional investors

Shares Owned by Institutions

Shares Purchased/Sold by Institutions

Ownership Summary

The institutional landscape for Fulcrum Therapeutics, Inc. (NASDAQ:FULC) includes 164 filers as of the latest reporting cycle ending December 2025.

Institutional ownership in Fulcrum Therapeutics edged up to 105.3% in December 2025, compared to 86.5% in September 2025.
On a quarter-over-quarter basis, institutional holdings shifted by 27.13%, with a year-over-year an increase of 34.43% in the count of filers.
The latest 13F cycle for Fulcrum Therapeutics reveals that of 164 total investors, 99 funds grew their exposure, whereas 47 reduced theirs and 18 made no changes.
The total number of shares held by institutions in Fulcrum Therapeutics increased to 65.68Mn as of December 2025, a net change of up by 14.01Mn shares quarter on quarter, and up 13.65Mn shares year over year.
With 6.56Mn shares, SUVRETTA CAPITAL MANAGEMENT, LLC commands the largest institutional position in Fulcrum Therapeutics as of December 31, 2025, equating to 10.52% of the company.
Among the most significant buyers of Fulcrum Therapeutics during December 2025 were BRAIDWELL LP (2.84Mn), Point72 Asset Management, L.P. (2.40Mn), Siren, L.L.C. (1.95Mn), First Turn Management, LLC (1.89Mn), GSK plc (1.79Mn).
Leading sellers of Fulcrum Therapeutics stock in December 2025 included RA CAPITAL MANAGEMENT, L.P. (4.18Mn), ROYAL BANK OF CANADA (996.74K), ADAGE CAPITAL PARTNERS GP, L.L.C. (732.00K), BALYASNY ASSET MANAGEMENT L.P. (480.04K), Nantahala Capital Management, LLC (377.44K).
The top 10 institutional holders of Fulcrum Therapeutics for the quarter ending December 2025 included SUVRETTA CAPITAL MANAGEMENT, LLC (6.56Mn), RA CAPITAL MANAGEMENT, L.P. (6.05Mn), TCG Crossover Management, LLC (5.25Mn), Nantahala Capital Management, LLC (4.29Mn), BlackRock, Inc. (4.26Mn), VANGUARD GROUP INC (3.56Mn), BRAIDWELL LP (3.06Mn), Point72 Asset Management, L.P. (2.40Mn), Siren, L.L.C. (1.95Mn), D. E. Shaw & Co., Inc. (1.91Mn).

164 Institutional Holders

5,984,410 Total Shares Held

Rows:

Download Data

Owner Name	Date	Shares Held	Change (QoQ)	Change (%)	Value (USD)
SUVRETTA CAPITAL MANAGEMENT, LLC	31 Dec, 2025	6,561,111	1,180,111	21.93%	$74,206,165.00
RA CAPITAL MANAGEMENT, L.P.	31 Dec, 2025	6,053,960	-4,175,139	-40.82%	$68,470,288.00
TCG Crossover Management, LLC	31 Dec, 2025	5,250,000	0	0.00%	$59,377,500.00
Nantahala Capital Management, LLC	31 Dec, 2025	4,293,346	-377,438	-8.08%	$48,557,743.00
BlackRock, Inc.	31 Dec, 2025	4,263,761	557,011	15.03%	$48,223,137.00
VANGUARD GROUP INC	31 Dec, 2025	3,559,552	560,088	18.67%	$40,258,533.00
BRAIDWELL LP	31 Dec, 2025	3,061,222	2,841,734	1,294.71%	$34,622,421.00
Point72 Asset Management, L.P.	31 Dec, 2025	2,398,232	2,398,232	0.00%	$27,124,004.00
Siren, L.L.C.	31 Dec, 2025	1,950,000	1,950,000	0.00%	$22,054,500.00
D. E. Shaw & Co., Inc.	31 Dec, 2025	1,913,755	464,332	32.04%	$21,644,569.00
First Turn Management, LLC	31 Dec, 2025	1,892,683	1,892,683	0.00%	$21,406,245.00
GSK plc	31 Dec, 2025	1,785,714	1,785,714	0.00%	$20,196,425.00
ADAGE CAPITAL PARTNERS GP, L.L.C.	31 Dec, 2025	1,700,000	-732,000	-30.10%	$19,227,000.00
ADAR1 Capital Management, LLC	31 Dec, 2025	1,318,749	902,137	216.54%	$14,915,051.00
Aberdeen Group plc	31 Dec, 2025	1,254,027	1,116,066	808.97%	$14,183,045.00
CITADEL ADVISORS LLC	31 Dec, 2025	1,207,004	352,448	41.24%	$13,651,216.00
GEODE CAPITAL MANAGEMENT, LLC	31 Dec, 2025	1,105,813	101,762	10.14%	$12,509,702.00
DIMENSIONAL FUND ADVISORS LP	31 Dec, 2025	1,051,124	-248,184	-19.10%	$11,888,372.00
STATE STREET CORP	31 Dec, 2025	1,005,345	-57,862	-5.44%	$11,370,452.00
BALYASNY ASSET MANAGEMENT L.P.	31 Dec, 2025	970,439	-480,041	-33.10%	$10,975,665.00

1 - 20 of 164

Research Tools