Eton Pharmaceuticals, Inc. (ETON) Institutional Ownership

Institutions by Trading Activity

Ownership Statistics

27,528,571Shares Outstanding

6,265,481Shares held by institutions

$107,452,999Value of institutional holdings

57.65%Institutional ownership %

-4.70%Shares Changed QoQ

98No. of institutional investors

Shares Owned by Institutions

Shares Purchased/Sold by Institutions

Ownership Summary

Recent 13F filings as of December 2025 show that 98 institutional investors hold a position in Eton Pharmaceuticals, Inc. (NASDAQ:ETON).

The percentage of Eton Pharmaceuticals owned by institutions changed from 64.2% in September 2025 to 57.7% in December 2025, marking a slight down trend.
The company experienced a -4.70% quarterly change in institutional shares held, alongside an increase of 38.03% in total owners annually.
Of these 98 institutional investors, 47 increased their holdings in Eton Pharmaceuticals, while 35 of them reduced positions, and 16 investors maintained their exposure.
Collectively, institutional investors decreased their stake in Eton Pharmaceuticals to 15.87Mn shares as of December 2025, a change that is down by 782.67K shares quarter on quarter and up 2.73Mn shares year over year.
As of December 31, 2025, Opaleye Management Inc. held Eton Pharmaceuticals's largest shareholding position with over 2.86Mn shares, representing 10.39% of total outstanding shares.
Among the most significant buyers of Eton Pharmaceuticals during December 2025 were OBERWEIS ASSET MANAGEMENT INC/ (238.94K), Woodline Partners LP (95.49K), Diametric Capital, LP (93.85K), CITADEL ADVISORS LLC (74.14K), STATE STREET CORP (63.48K).
Leading sellers of Eton Pharmaceuticals stock in December 2025 included ROYAL BANK OF CANADA (478.18K), CANNELL CAPITAL LLC (238.49K), TWO SIGMA INVESTMENTS, LP (209.82K), JPMORGAN CHASE & CO (165.98K), TWO SIGMA ADVISERS, LP (154.20K).
The top 10 institutional holders of Eton Pharmaceuticals for the quarter ending December 2025 included Opaleye Management Inc. (2.86Mn), EcoR1 Capital, LLC (2.03Mn), BlackRock, Inc. (1.74Mn), VANGUARD GROUP INC (1.35Mn), Nantahala Capital Management, LLC (1.18Mn), GEODE CAPITAL MANAGEMENT, LLC (565.05K), STATE STREET CORP (501.93K), MORGAN STANLEY (493.91K), Westside Investment Management, Inc. (470.94K), OBERWEIS ASSET MANAGEMENT INC/ (431.30K).

98 Institutional Holders

6,265,481 Total Shares Held

Rows:

Download Data

Owner Name	Date	Shares Held	Change (QoQ)	Change (%)	Value (USD)
Opaleye Management Inc.	31 Dec, 2025	2,860,000	0	0.00%	$48,362,600.00
EcoR1 Capital, LLC	31 Dec, 2025	2,030,544	0	0.00%	$34,336,499.00
BlackRock, Inc.	31 Dec, 2025	1,738,907	34,546	2.03%	$29,404,917.00
VANGUARD GROUP INC	31 Dec, 2025	1,348,668	4,553	0.34%	$22,805,976.00
Nantahala Capital Management, LLC	31 Dec, 2025	1,175,951	0	0.00%	$19,885,331.00
GEODE CAPITAL MANAGEMENT, LLC	31 Dec, 2025	565,051	-8,979	-1.56%	$9,557,084.00
STATE STREET CORP	31 Dec, 2025	501,925	63,480	14.48%	$8,487,552.00
MORGAN STANLEY	31 Dec, 2025	493,914	-92,132	-15.72%	$8,352,085.00
Westside Investment Management, Inc.	31 Dec, 2025	470,940	-1,600	-0.34%	$7,963,285.00
OBERWEIS ASSET MANAGEMENT INC/	31 Dec, 2025	431,300	238,940	124.22%	$7,293,283.00
THOMPSON SIEGEL & WALMSLEY LLC	31 Dec, 2025	408,541	-10,025	-2.40%	$6,908.00
BNP PARIBAS FINANCIAL MARKETS	31 Dec, 2025	277,458	47,668	20.74%	$4,691,815.00
NORTHERN TRUST CORP	31 Dec, 2025	231,849	-13,202	-5.39%	$3,920,566.00
CANNELL CAPITAL LLC	31 Dec, 2025	216,917	-238,488	-52.37%	$3,668,066.00
RENAISSANCE TECHNOLOGIES LLC	31 Dec, 2025	205,700	-118,921	-36.63%	$3,478,387.00
GOLDMAN SACHS GROUP INC	31 Dec, 2025	196,263	6,099	3.21%	$3,318,807.00
Diametric Capital, LP	31 Dec, 2025	193,155	93,846	94.50%	$3,266,251.00
JPMORGAN CHASE & CO	31 Dec, 2025	185,439	-165,978	-47.23%	$3,135,773.00
Lumbard & Kellner, LLC	31 Dec, 2025	174,944	-1,356	-0.77%	$2,958,303.00
Aristides Capital LLC	31 Dec, 2025	161,436	-6,151	-3.67%	$2,729,883.00

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