Eton Pharmaceuticals, Inc. (ETON) Institutional Ownership

Institutions by Trading Activity

Ownership Statistics

26,893,000Shares Outstanding

16,239,708Shares held by institutions

$382,282,726Value of institutional holdings

60.39%Institutional ownership %

-5.67%Shares Changed QoQ

101No. of institutional investors

Shares Owned by Institutions

Shares Purchased/Sold by Institutions

Ownership Summary

Eton Pharmaceuticals, Inc. (NASDAQ:ETON) has 101 institutional investors with active 13F positions as of December 2025.

These investors collectively held 59.7% of Eton Pharmaceuticals's outstanding shares in December 2025, down from 67.3% in September 2025.
Their total shares held in ETON decreased -6.61% quarter over quarter, and separately, investors owning Eton Pharmaceuticals increased 42.25% from a year ago.
Of these 101 holders, 48 added to their stakes in Eton Pharmaceuticals, 37 trimmed positions, and 16 made no changes.
The aggregate institutional position in Eton Pharmaceuticals amounted to 16.04Mn shares as of December 2025, down by 1.14Mn shares quarter on quarter, and up 2.86Mn shares year over year.
Opaleye Management Inc. leads ownership in ETON with 2.86Mn shares as of December 31, 2025, equal to 10.63% of outstanding shares.
The most significant purchases of ETON for the quarter ending December 2025 came from OBERWEIS ASSET MANAGEMENT INC/ (238.94K), Goldman Sachs Group Inc (202.36K), Aristides Capital LLC (155.28K), Woodline Partners LP (95.49K), Diametric Capital, LP (93.85K).
Leading sellers of Eton Pharmaceuticals shares for the quarter ending December 2025 were Jpmorgan Chase & Co (517.4K), Royal Bank Of Canada (478.18K), CANNELL CAPITAL LLC (238.49K), TWO SIGMA INVESTMENTS, LP (209.82K), TWO SIGMA ADVISERS, LP (154.2K).
Eton Pharmaceuticals's 10 largest shareholders as of December 2025 include Opaleye Management Inc. (2.86Mn), EcoR1 Capital, LLC (2.03Mn), BlackRock, Inc. (1.74Mn), VANGUARD GROUP INC (1.35Mn), Nantahala Capital Management, LLC (1.18Mn), GEODE CAPITAL MANAGEMENT, LLC (565.05K), State Street Corp (501.92K), Morgan Stanley (493.91K), Westside Investment Management, Inc. (470.94K), OBERWEIS ASSET MANAGEMENT INC/ (431.3K) per Business Quant data.

101 Institutional Holders

16,239,708 Total Shares Held

Rows:

Download Data

Owner Name	Date	Shares Held	Change (QoQ)	Change (%)	Value (USD)
Opaleye Management Inc.	31 Dec, 2025	2,860,000	0	0.00%	$48,362,600.00
EcoR1 Capital, LLC	31 Dec, 2025	2,030,544	0	0.00%	$34,336,499.00
BlackRock, Inc.	31 Dec, 2025	1,738,907	34,546	2.03%	$29,404,917.00
VANGUARD GROUP INC	31 Dec, 2025	1,348,668	4,553	0.34%	$22,805,976.00
Nantahala Capital Management, LLC	31 Dec, 2025	1,175,951	0	0.00%	$19,885,331.00
GEODE CAPITAL MANAGEMENT, LLC	31 Dec, 2025	565,051	-8,979	-1.56%	$9,557,084.00
State Street Corp	31 Dec, 2025	501,925	63,480	14.48%	$8,487,552.00
Morgan Stanley	31 Dec, 2025	493,914	-92,132	-15.72%	$8,352,085.00
Westside Investment Management, Inc.	31 Dec, 2025	470,940	-1,600	-0.34%	$7,963,285.00
OBERWEIS ASSET MANAGEMENT INC/	31 Dec, 2025	431,300	238,940	124.22%	$7,293,283.00
THOMPSON SIEGEL & WALMSLEY LLC	31 Dec, 2025	408,541	-10,025	-2.40%	$6,908.00
Goldman Sachs Group Inc	31 Dec, 2025	392,526	202,362	106.41%	$6,637,614.00
Aristides Capital LLC	31 Dec, 2025	322,872	155,285	92.66%	$5,459,766.00
BNP PARIBAS FINANCIAL MARKETS	31 Dec, 2025	277,458	47,668	20.74%	$4,691,815.00
Northern Trust Corp	31 Dec, 2025	231,849	-13,202	-5.39%	$3,920,566.00
CANNELL CAPITAL LLC	31 Dec, 2025	216,917	-238,488	-52.37%	$3,668,066.00
RENAISSANCE TECHNOLOGIES LLC	31 Dec, 2025	205,700	-118,921	-36.63%	$3,478,387.00
Diametric Capital, LP	31 Dec, 2025	193,155	93,846	94.50%	$3,266,251.00
Jpmorgan Chase & Co	31 Dec, 2025	185,439	-517,395	-73.62%	$3,135,773.00
Lumbard & Kellner, LLC	31 Dec, 2025	174,944	-1,356	-0.77%	$2,958,303.00

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