Bicycle Therapeutics Plc (BCYC) Institutional Ownership

Institutions by Trading Activity

Ownership Statistics

69,529,412Shares Outstanding

14,068,260Shares held by institutions

$73,577,000Value of institutional holdings

54.30%Institutional ownership %

7.45%Shares Changed QoQ

102No. of institutional investors

Shares Owned by Institutions

Shares Purchased/Sold by Institutions

Ownership Summary

Bicycle Therapeutics Plc (NASDAQ:BCYC) currently has 102 active institutional owners and shareholders as of today (December 2025), that have filed 13F forms with the Securities Exchange Commission (SEC).

The collective stake of institutional investors in Bicycle Therapeutics moved to 54.3% in December 2025, a shift up from the 53.1% reported for September 2025.
The company experienced a 7.45% quarterly change in institutional shares held, alongside an increase of 6.25% in total owners annually.
During the quarter, 52 institutions bought more Bicycle Therapeutics shares, 28 sold shares, and 22 of the 102 total investors held their position steady.
The total number of shares held by institutions in Bicycle Therapeutics increased to 37.75Mn as of December 2025, a net change of up by 2.62Mn shares quarter on quarter, and down 3.37Mn shares year over year.
BAKER BROS. ADVISORS LP continues to be the largest institutional holder of Bicycle Therapeutics as of December 31, 2025, with a position of 10.89Mn shares, representing 15.66% of the company's outstanding stock.
Among the most significant buyers of Bicycle Therapeutics during December 2025 were GSK plc (1.53Mn), SCHRODER INVESTMENT MANAGEMENT GROUP (584.77K), BNP Paribas Asset Management Holding S.A. (568.23K), ACADIAN ASSET MANAGEMENT LLC (356.70K), Birchview Capital, LP (308.70K).
Leading sellers of Bicycle Therapeutics stock in December 2025 included MILLENNIUM MANAGEMENT LLC (728.12K), BANK OF AMERICA CORP /DE/ (495.13K), MORGAN STANLEY (357.48K), Point72 Asset Management, L.P. (354.12K), Legal & General Group Plc (188.86K).
The top 10 institutional holders of Bicycle Therapeutics for the quarter ending December 2025 included BAKER BROS. ADVISORS LP (10.89Mn), FCPM III SERVICES B.V. (3.47Mn), ARMISTICE CAPITAL, LLC (3.24Mn), WESTFIELD CAPITAL MANAGEMENT CO LP (3.02Mn), Siren, L.L.C. (2.01Mn), ACADIAN ASSET MANAGEMENT LLC (1.67Mn), Long Focus Capital Management, LLC (1.63Mn), GSK plc (1.53Mn), Candriam S.C.A. (1.19Mn), PRINCIPAL FINANCIAL GROUP INC (1.15Mn).

102 Institutional Holders

14,068,260 Total Shares Held

Rows:

Download Data

Owner Name	Date	Shares Held	Change (QoQ)	Change (%)	Value (USD)
BAKER BROS. ADVISORS LP	31 Dec, 2025	10,885,357	0	0.00%	$77,068,328.00
FCPM III SERVICES B.V.	31 Dec, 2025	3,468,430	16,100	0.47%	$24,556,484.00
ARMISTICE CAPITAL, LLC	31 Dec, 2025	3,236,000	258,000	8.66%	$22,910,880.00
WESTFIELD CAPITAL MANAGEMENT CO LP	31 Dec, 2025	3,016,026	63,483	2.15%	$21,353,464.00
Siren, L.L.C.	31 Dec, 2025	2,012,752	0	0.00%	$14,250,284.00
ACADIAN ASSET MANAGEMENT LLC	31 Dec, 2025	1,671,258	356,702	27.13%	$11,806.00
Long Focus Capital Management, LLC	31 Dec, 2025	1,633,091	214,396	15.11%	$11,562,284.00
GSK plc	31 Dec, 2025	1,529,561	1,529,561	0.00%	$10,829,292.00
Candriam S.C.A.	31 Dec, 2025	1,192,279	19,892	1.70%	$8,441,695.00
PRINCIPAL FINANCIAL GROUP INC	31 Dec, 2025	1,148,272	-130	-0.01%	$8,129,766.00
SCHRODER INVESTMENT MANAGEMENT GROUP	31 Dec, 2025	584,770	584,770	0.00%	$3,976,436.00
BNP Paribas Asset Management Holding S.A.	31 Dec, 2025	568,225	568,225	0.00%	$4,023.00
RENAISSANCE TECHNOLOGIES LLC	31 Dec, 2025	566,600	47,900	9.23%	$4,011,528.00
SILVERCREST ASSET MANAGEMENT GROUP LLC	31 Dec, 2025	476,976	0	0.00%	$3,376,990.00
MORGAN STANLEY	31 Dec, 2025	465,222	-357,483	-43.45%	$3,293,773.00
Birchview Capital, LP	31 Dec, 2025	462,700	308,700	200.45%	$3,275,916.00
BlackRock, Inc.	31 Dec, 2025	332,889	50,471	17.87%	$2,356,854.00
MILLENNIUM MANAGEMENT LLC	31 Dec, 2025	326,626	-728,120	-69.03%	$2,312,512.00
Jefferies Financial Group Inc.	31 Dec, 2025	297,247	-104,679	-26.04%	$2,104,509.00
MOORE CAPITAL MANAGEMENT, LP	31 Dec, 2025	275,000	150,000	120.00%	$1,947,000.00

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