Bicycle Therapeutics Plc (BCYC) Institutional Ownership

Ownership Summary

Bicycle Therapeutics Plc (NASDAQ:BCYC) showed up in the 13F filings of 97 institutional investors as of March 2026.

• These investors collectively held 53.8% of Bicycle Therapeutics's outstanding shares in March 2026, down from 55.1% in December 2025.
• They increased total shares held in Bicycle Therapeutics by 15.89% from last quarter, and the number of investors in BCYC increased 1.04% annually.
• Among the 97 funds, 59 bought more Bicycle Therapeutics shares, 16 sold down, and 22 held their ground.
• Institutional investors collectively held 37.46Mn shares in Bicycle Therapeutics as of March 2026, up by 5.14Mn shares quarter on quarter, and down 9.91Mn shares year over year.
• As of March 31, 2026, the biggest holder of Bicycle Therapeutics is BAKER BROS. ADVISORS LP at 10.89Mn shares, representing 15.62% of shares outstanding.
• Top purchasers of BCYC stock for the quarter ending March 2026 included Long Focus Capital Management, LLC (1.68Mn), PRICE T ROWE ASSOCIATES INC /MD/ (1.03Mn), DIADEMA PARTNERS LP (476.42K), RENAISSANCE TECHNOLOGIES LLC (412.7K), MARSHALL WACE, LLP (338.54K).
• Top sellers of BCYC stock for the quarter ending March 2026 included Siren, L.L.C. (451.87K), FIDEURAM - INTESA SANPAOLO PRIVATE BANKING S.P.A. (269.37K), SUSQUEHANNA INTERNATIONAL GROUP, LLP (70.54K), TD ASSET MANAGEMENT INC (56.0K), BlackRock, Inc. (53.9K).
• Business Quant data shows the 10 biggest positions in Bicycle Therapeutics as of March 2026 are held by BAKER BROS. ADVISORS LP (10.89Mn), FCPM III SERVICES B.V. (3.47Mn), ARMISTICE CAPITAL, LLC (3.4Mn), Long Focus Capital Management, LLC (3.31Mn), ACADIAN ASSET MANAGEMENT LLC (1.97Mn), Siren, L.L.C. (1.56Mn), GSK plc (1.53Mn), Principal Financial Group Inc (1.17Mn), PRICE T ROWE ASSOCIATES INC /MD/ (1.03Mn), RENAISSANCE TECHNOLOGIES LLC (979.3K).