Biocryst Pharmaceuticals Inc (BCRX) Institutional Ownership

Institutions by Trading Activity

Ownership Statistics

175,580,000Shares Outstanding

2,278,852Shares held by institutions

$15,838,021Value of institutional holdings

117.74%Institutional ownership %

18.46%Shares Changed QoQ

260No. of institutional investors

Shares Owned by Institutions

Shares Purchased/Sold by Institutions

Ownership Summary

Biocryst Pharmaceuticals Inc (NASDAQ:BCRX) currently has 260 active institutional owners and shareholders as of today (December 2025), that have filed 13F forms with the Securities Exchange Commission (SEC).

Biocryst Pharmaceuticals saw its institutional ownership percentage rose to 117.7% in December 2025 from 111.1% in September 2025.
The company experienced a 18.46% quarterly change in institutional shares held, alongside an increase of 1.96% in total owners annually.
A review of institutional activity for Biocryst Pharmaceuticals shows 134 of 260 filers increasing their positions, while 95 reduced their stake, and 31 remained unchanged.
The aggregate institutional position in Biocryst Pharmaceuticals now stands at 206.73Mn shares as of December 2025, after investors increased their holdings (up by 32.22Mn shares quarter on quarter which is up 38.35Mn shares year over year).
VANGUARD GROUP INC's holding of 22.27Mn shares as of December 31, 2025 makes it the primary institutional investor in Biocryst Pharmaceuticals, owning 12.69% of the stock.
Among the most significant buyers of Biocryst Pharmaceuticals during December 2025 were RA CAPITAL MANAGEMENT, L.P. (15.83Mn), JANUS HENDERSON GROUP PLC (7.31Mn), PERCEPTIVE ADVISORS LLC (3.16Mn), BAKER BROS. ADVISORS LP (2.82Mn), Vestal Point Capital, LP (2.25Mn).
Leading sellers of Biocryst Pharmaceuticals stock in December 2025 included ARROWSTREET CAPITAL, LIMITED PARTNERSHIP (5.16Mn), MORGAN STANLEY (3.46Mn), Assenagon Asset Management S.A. (2.73Mn), JANE STREET GROUP, LLC (1.15Mn), JUPITER ASSET MANAGEMENT LTD (858.30K).
The top 10 institutional holders of Biocryst Pharmaceuticals for the quarter ending December 2025 included VANGUARD GROUP INC (22.27Mn), BlackRock, Inc. (21.14Mn), RA CAPITAL MANAGEMENT, L.P. (15.83Mn), DEERFIELD MANAGEMENT COMPANY, L.P. (14.34Mn), STATE STREET CORP (11.07Mn), Kynam Capital Management, LP (9.37Mn), JANUS HENDERSON GROUP PLC (7.40Mn), UBS Group AG (5.27Mn), GEODE CAPITAL MANAGEMENT, LLC (5.05Mn), TWO SIGMA INVESTMENTS, LP (4.52Mn).

260 Institutional Holders

2,278,852 Total Shares Held

Rows:

Download Data

Owner Name	Date	Shares Held	Change (QoQ)	Change (%)	Value (USD)
VANGUARD GROUP INC	31 Dec, 2025	22,273,375	482,494	2.21%	$173,732,325.00
BlackRock, Inc.	31 Dec, 2025	21,137,791	-108,085	-0.51%	$164,874,767.00
RA CAPITAL MANAGEMENT, L.P.	31 Dec, 2025	15,827,186	15,827,186	0.00%	$123,452,051.00
DEERFIELD MANAGEMENT COMPANY, L.P.	31 Dec, 2025	14,341,000	2,172,000	17.85%	$111,859,800.00
STATE STREET CORP	31 Dec, 2025	11,073,211	1,265,773	12.91%	$86,371,046.00
Kynam Capital Management, LP	31 Dec, 2025	9,366,526	-23,744	-0.25%	$73,058,903.00
JANUS HENDERSON GROUP PLC	31 Dec, 2025	7,404,386	7,310,745	7,807.21%	$57,791,233.00
UBS Group AG	31 Dec, 2025	5,271,914	-695,823	-11.66%	$41,120,929.00
GEODE CAPITAL MANAGEMENT, LLC	31 Dec, 2025	5,053,786	1,479	0.03%	$39,426,800.00
TWO SIGMA INVESTMENTS, LP	31 Dec, 2025	4,515,317	95,688	2.17%	$35,219,473.00
TWO SIGMA ADVISERS, LP	31 Dec, 2025	4,089,112	-151,600	-3.57%	$31,895,074.00
Nuveen, LLC	31 Dec, 2025	3,612,366	-5,516	-0.15%	$28,176,454.00
GOLDMAN SACHS GROUP INC	31 Dec, 2025	3,212,785	500,979	18.47%	$25,059,723.00
PERCEPTIVE ADVISORS LLC	31 Dec, 2025	3,162,529	3,162,529	0.00%	$24,667,726.00
GW&K Investment Management, LLC	31 Dec, 2025	3,160,924	963,159	43.82%	$24,655.00
Eversept Partners, LP	31 Dec, 2025	2,992,895	1,619,270	117.88%	$23,344,581.00
BAKER BROS. ADVISORS LP	31 Dec, 2025	2,822,727	2,822,727	0.00%	$22,017,271.00
BNP PARIBAS FINANCIAL MARKETS	31 Dec, 2025	2,542,714	448,436	21.41%	$19,833,169.00
Fisher Asset Management, LLC	31 Dec, 2025	2,467,567	-165,129	-6.27%	$19,247,022.00
Vestal Point Capital, LP	31 Dec, 2025	2,250,000	2,250,000	0.00%	$17,550,000.00

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