Anaptysbio, Inc (ANAB) Institutional Ownership

Ownership Summary

Anaptysbio, Inc (NASDAQ:ANAB) has 173 institutional investors that have filed 13F reports for the period ending December 2025.

• They owned 100.3% of outstanding stock in December 2025, down from 109.7% the prior quarter.
• Their total shares held in ANAB decreased -1.56% quarter over quarter, and separately, investors owning Anaptysbio increased 28.15% from a year ago.
• Of these 173 funds, 84 grew their exposure to Anaptysbio, 66 cut back, and 23 maintained positions.
• Institutional investors collectively held 29.11Mn shares in Anaptysbio as of December 2025, down by 459.91K shares quarter on quarter, and down 6.58Mn shares year over year.
• EcoR1 Capital, LLC leads ownership in ANAB with 7.88Mn shares as of December 31, 2025, equal to 27.16% of outstanding shares.
• The most significant purchases of ANAB for the quarter ending December 2025 came from Affinity Asset Advisors, LLC (444.69K), D. E. Shaw & Co., Inc. (320.93K), VOLORIDGE INVESTMENT MANAGEMENT, LLC (219.82K), ARROWSTREET CAPITAL, LIMITED PARTNERSHIP (189.29K), State Street Corp (180.04K).
• Leading sellers of Anaptysbio shares for the quarter ending December 2025 were MILLENNIUM MANAGEMENT LLC (705.66K), Morgan Stanley (521.7K), Soleus Capital Management, L.P. (491.04K), First Light Asset Management, LLC (343.92K), Point72 Asset Management, L.P. (332.64K).
• Business Quant data shows the 10 biggest positions in Anaptysbio as of December 2025 are held by EcoR1 Capital, LLC (7.88Mn), Point72 Asset Management, L.P. (1.93Mn), BlackRock, Inc. (1.73Mn), VANGUARD GROUP INC (1.54Mn), TANG CAPITAL MANAGEMENT LLC (1.33Mn), State Street Corp (1.05Mn), Morgan Stanley (1.03Mn), Sanofi (821.92K), MILLENNIUM MANAGEMENT LLC (813.57K), Palo Alto Investors LP (690.03K).