Anaptysbio, Inc (ANAB) Institutional Ownership

Institutions by Trading Activity

Ownership Statistics

30,663,043Shares Outstanding

9,293,811Shares held by institutions

$499,077,651Value of institutional holdings

95.53%Institutional ownership %

-0.40%Shares Changed QoQ

171No. of institutional investors

Shares Owned by Institutions

Shares Purchased/Sold by Institutions

Ownership Summary

According to SEC filings for the period ending December 2025, Anaptysbio, Inc (NASDAQ:ANAB) is held by 171 institutional firms.

These investors collectively held 95.5% of the company's total shares outstanding in December 2025, down from 103.4% in September 2025.
On a quarter-over-quarter basis, institutional holdings shifted by -0.40%, with a year-over-year an increase of 24.82% in the count of filers.
Among the 171 institutional holders of Anaptysbio, 85 added to their stakes while 64 trimmed their positions and 22 held steady.
The aggregate institutional position in Anaptysbio now stands at 29.29Mn shares as of December 2025, after investors decreased their holdings (down by 117.08K shares quarter on quarter which is down 7.80Mn shares year over year).
As of December 31, 2025, EcoR1 Capital, LLC held Anaptysbio's largest shareholding position with over 7.88Mn shares, representing 25.70% of total outstanding shares.
Among the most significant buyers of Anaptysbio during December 2025 were Affinity Asset Advisors, LLC (444.69K), D. E. Shaw & Co., Inc. (320.93K), VOLORIDGE INVESTMENT MANAGEMENT, LLC (219.82K), Caption Management, LLC (200.00K), ARROWSTREET CAPITAL, LIMITED PARTNERSHIP (189.29K).
Leading sellers of Anaptysbio stock in December 2025 included MILLENNIUM MANAGEMENT LLC (715.76K), MORGAN STANLEY (521.70K), Soleus Capital Management, L.P. (491.04K), First Light Asset Management, LLC (343.92K), Point72 Asset Management, L.P. (332.64K).
The top 10 institutional holders of Anaptysbio for the quarter ending December 2025 included EcoR1 Capital, LLC (7.88Mn), Point72 Asset Management, L.P. (1.93Mn), BlackRock, Inc. (1.73Mn), VANGUARD GROUP INC (1.54Mn), TANG CAPITAL MANAGEMENT LLC (1.33Mn), STATE STREET CORP (1.05Mn), MORGAN STANLEY (1.03Mn), Sanofi (821.92K), MILLENNIUM MANAGEMENT LLC (813.57K), Palo Alto Investors LP (690.03K).

171 Institutional Holders

9,293,811 Total Shares Held

Rows:

Download Data

Owner Name	Date	Shares Held	Change (QoQ)	Change (%)	Value (USD)
EcoR1 Capital, LLC	31 Dec, 2025	7,880,094	0	0.00%	$382,026,957.00
Point72 Asset Management, L.P.	31 Dec, 2025	1,932,890	-332,638	-14.68%	$93,706,507.00
BlackRock, Inc.	31 Dec, 2025	1,734,430	12,106	0.70%	$84,085,167.00
VANGUARD GROUP INC	31 Dec, 2025	1,544,037	67,048	4.54%	$74,854,914.00
TANG CAPITAL MANAGEMENT LLC	31 Dec, 2025	1,332,087	-1,552	-0.12%	$64,579,578.00
STATE STREET CORP	31 Dec, 2025	1,053,474	180,042	20.61%	$51,072,420.00
MORGAN STANLEY	31 Dec, 2025	1,034,562	-521,696	-33.52%	$50,155,606.00
Sanofi	31 Dec, 2025	821,917	0	0.00%	$39,846,536.00
MILLENNIUM MANAGEMENT LLC	31 Dec, 2025	813,571	-715,759	-46.80%	$39,441,922.00
Palo Alto Investors LP	31 Dec, 2025	690,032	16,512	2.45%	$33,452,751.00
D. E. Shaw & Co., Inc.	31 Dec, 2025	670,288	320,928	91.86%	$32,495,563.00
683 Capital Management, LLC	31 Dec, 2025	648,093	101,093	18.48%	$31,419,548.00
First Light Asset Management, LLC	31 Dec, 2025	646,238	-343,923	-34.73%	$31,329,618.00
ARROWSTREET CAPITAL, LIMITED PARTNERSHIP	31 Dec, 2025	559,744	189,286	51.10%	$27,136,389.00
Woodline Partners LP	31 Dec, 2025	501,023	0	0.00%	$24,289,595.00
GEODE CAPITAL MANAGEMENT, LLC	31 Dec, 2025	469,494	-4,132	-0.87%	$22,766,046.00
Affinity Asset Advisors, LLC	31 Dec, 2025	444,692	444,692	0.00%	$21,558,668.00
GOLDMAN SACHS GROUP INC	31 Dec, 2025	398,914	69,094	20.95%	$19,339,351.00
TWO SIGMA ADVISERS, LP	31 Dec, 2025	356,700	-17,000	-4.55%	$17,292,816.00
Nuveen, LLC	31 Dec, 2025	316,685	-22,586	-6.66%	$15,352,889.00

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