AC Immune SA (ACIU) Institutional Ownership

Institutions by Trading Activity

Ownership Statistics

123,890,625Shares Outstanding

20,206,174Shares held by institutions

$58,799,966Value of institutional holdings

20.83%Institutional ownership %

6.51%Shares Changed QoQ

41No. of institutional investors

Shares Owned by Institutions

Shares Purchased/Sold by Institutions

Ownership Summary

AC Immune SA (NASDAQ:ACIU) currently has 41 active institutional owners and shareholders as of today (December 2025), that have filed 13F forms with the Securities Exchange Commission (SEC).

AC Immune saw its institutional ownership percentage rose to 20.8% in December 2025 from 20.0% in September 2025.
Institutional share ownership changed by 6.51% QoQ, while the number of institutional owners saw a decrease of 10.87% YoY.
Of these 41 institutional investors, 21 increased their holdings in AC Immune, while 11 of them reduced positions, and 9 investors maintained their exposure.
Collectively, institutional investors increased their stake in AC Immune to 25.81Mn shares as of December 2025, a change that is up by 1.58Mn shares quarter on quarter and down 1.56Mn shares year over year.
As of December 31, 2025, BVF INC/IL held AC Immune's largest shareholding position with over 19.82Mn shares, representing 16.00% of total outstanding shares.
Among the most significant buyers of AC Immune during December 2025 were Point72 Asset Management, L.P. (384.85K), ARROWSTREET CAPITAL, LIMITED PARTNERSHIP (375.62K), MARSHALL WACE, LLP (186.71K), UBS Group AG (177.93K), SUSQUEHANNA INTERNATIONAL GROUP, LLP (125.78K).
Leading sellers of AC Immune stock in December 2025 included RENAISSANCE TECHNOLOGIES LLC (101.55K), MILLENNIUM MANAGEMENT LLC (56.09K), Banque Cantonale Vaudoise (10.55K), WELLS FARGO & COMPANY/MN (4.23K), BARCLAYS PLC (2.59K).
The top 10 institutional holders of AC Immune for the quarter ending December 2025 included BVF INC/IL (19.82Mn), WELLS FARGO & COMPANY/MN (1.01Mn), MILLENNIUM MANAGEMENT LLC (933.34K), RENAISSANCE TECHNOLOGIES LLC (668.87K), BlackRock, Inc. (502.17K), ACADIAN ASSET MANAGEMENT LLC (464.70K), Point72 Asset Management, L.P. (384.85K), ARROWSTREET CAPITAL, LIMITED PARTNERSHIP (375.62K), NORTHERN TRUST CORP (281.95K), DIMENSIONAL FUND ADVISORS LP (213.46K).

41 Institutional Holders

20,206,174 Total Shares Held

Rows:

Download Data

Owner Name	Date	Shares Held	Change (QoQ)	Change (%)	Value (USD)
BVF INC/IL	31 Dec, 2025	19,822,436	0	0.00%	$62,242,449.00
WELLS FARGO & COMPANY/MN	31 Dec, 2025	1,006,289	-4,232	-0.42%	$3,159,749.00
MILLENNIUM MANAGEMENT LLC	31 Dec, 2025	933,342	-56,090	-5.67%	$2,930,694.00
RENAISSANCE TECHNOLOGIES LLC	31 Dec, 2025	668,867	-101,552	-13.18%	$2,100,242.00
BlackRock, Inc.	31 Dec, 2025	502,169	90,321	21.93%	$1,576,811.00
ACADIAN ASSET MANAGEMENT LLC	31 Dec, 2025	464,697	51,460	12.45%	$1,441.00
Point72 Asset Management, L.P.	31 Dec, 2025	384,845	384,845	0.00%	$1,208,413.00
ARROWSTREET CAPITAL, LIMITED PARTNERSHIP	31 Dec, 2025	375,623	375,623	0.00%	$1,179,456.00
NORTHERN TRUST CORP	31 Dec, 2025	281,953	0	0.00%	$885,332.00
DIMENSIONAL FUND ADVISORS LP	31 Dec, 2025	213,464	36,353	20.53%	$670,374.00
UBS Group AG	31 Dec, 2025	194,349	177,925	1,083.32%	$610,256.00
MARSHALL WACE, LLP	31 Dec, 2025	186,709	186,709	0.00%	$586,265.00
SUSQUEHANNA INTERNATIONAL GROUP, LLP	31 Dec, 2025	147,625	125,785	575.94%	$463,542.00
Dauntless Investment Group, LLC	31 Dec, 2025	115,677	115,677	0.00%	$363,226.00
MORGAN STANLEY	31 Dec, 2025	94,345	2,312	2.51%	$296,242.00
TWO SIGMA INVESTMENTS, LP	31 Dec, 2025	87,884	71,109	423.90%	$275,956.00
CITADEL ADVISORS LLC	31 Dec, 2025	71,151	51,038	253.76%	$223,414.00
GEODE CAPITAL MANAGEMENT, LLC	31 Dec, 2025	63,601	0	0.00%	$199,707.00
JANE STREET GROUP, LLC	31 Dec, 2025	42,610	42,610	0.00%	$133,795.00
BANK OF AMERICA CORP /DE/	31 Dec, 2025	21,471	15,555	262.93%	$67,419.00

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