Zymeworks (ZYME) EBITDA (2021 - 2026)

Zymeworks' (ZYME) quarterly EBITDA came in at -$44.6 million in Q1 2026, down 102.12% year-on-year from $2.1 billion in Q1 2025, and down 8.27% quarter-over-quarter from -$41.2 million in Q4 2025.

Zymeworks (ZYME) EBITDA (2021 - 2026) Analysis & Trends

Zymeworks has disclosed EBITDA across 6 years of filings, most recently posting -$44.6 million for Q1 2026.

  • EBITDA for Q1 2026 came in at -$44.6 million, down 102.12% year-over-year; the trailing twelve-month figure through Mar 2026 was -$102.8 million (up 8.5% YoY), and the FY2025 annual result was -$80.3 million, up 34.77% from the prior year.
  • EBITDA came in at -$44.6 million for Q1 2026 at Zymeworks, down from -$41.2 million in the prior quarter.
  • In the past five years, EBITDA ranged from a high of $309.4 million in Q4 2022 to a low of -$72.6 million in Q1 2022.
  • The 5-year median for EBITDA is -$29.2 million (2023), against an average of -$14.2 million.
  • Across the five-year window, EBITDA surged 890.33% in 2022 and sank 104.13% in 2023, its largest moves.
  • Zymeworks' EBITDA stood at $309.4 million in 2022, then tumbled by 104.13% to -$12.8 million in 2023, then tumbled by 91.28% to -$24.5 million in 2024, then tumbled by 68.6% to -$41.2 million in 2025, then declined by 8.27% to -$44.6 million in 2026.
  • The last three EBITDA figures came in at -$44.6 million (Q1 2026), -$41.2 million (Q4 2025), and -$19.3 million (Q3 2025), per Business Quant data.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) EBITDA (Qtr)
1 Alterity Therapeutics 925,601.88 Bn 925,601.85 Bn - -
2 Belite Bio 58,560.00 Bn 58,560.00 Bn - -26.92 Mn
3 Quantum Biopharma 17,284.41 Bn 17,284.40 Bn - -13.63 Mn
4 Legend Biotech 2,809.00 Bn 2,808.71 Bn 242.10 Mn -19.70 Mn
5 Evaxion A 1,334.43 Bn 1,334.42 Bn - -3.82 Mn
6 Akari Therapeutics 1,312.27 Bn 1,312.26 Bn - -14.44 Mn
7 Psyence Biomedical 212.16 Bn 212.16 Bn - -752,618.00
8 Vertex Pharmaceuticals 114.83 Bn 107.58 Bn 2.59 Bn 1.14 Bn
9 Abivax 91.96 Bn 91.96 Bn - -65.83 Mn
10 Zymeworks 1.73 Bn 1.36 Bn - -44.65 Mn

Historic Data

Download Data
DateValue
Mar 31, 2026 -44.65 Mn
Dec 31, 2025 -41.24 Mn
Sep 30, 2025 -19.31 Mn
Jun 30, 2025 2.38 Mn
Mar 31, 2025 -22.09 Mn
Dec 31, 2024 -24.46 Mn
Sep 30, 2024 -27.95 Mn
Jun 30, 2024 -37.87 Mn
Mar 31, 2024 -32.77 Mn
Dec 31, 2023 -12.79 Mn
Sep 30, 2023 -29.17 Mn
Jun 30, 2023 -53.03 Mn
Mar 31, 2023 -23.63 Mn
Dec 31, 2022 309.43 Mn
Sep 30, 2022 -47.85 Mn
Jun 30, 2022 -64.62 Mn
Mar 31, 2022 -72.63 Mn
Dec 31, 2021 -39.15 Mn
Sep 30, 2021 -60.58 Mn