Zymeworks (ZYME) EBITDA (2021 - 2026)
Zymeworks' (ZYME) quarterly EBITDA came in at -$44.6 million in Q1 2026, down 102.12% year-on-year from $2.1 billion in Q1 2025, and down 8.27% quarter-over-quarter from -$41.2 million in Q4 2025.
Zymeworks (ZYME) EBITDA (2021 - 2026) Analysis & Trends
Zymeworks has disclosed EBITDA across 6 years of filings, most recently posting -$44.6 million for Q1 2026.
- EBITDA for Q1 2026 came in at -$44.6 million, down 102.12% year-over-year; the trailing twelve-month figure through Mar 2026 was -$102.8 million (up 8.5% YoY), and the FY2025 annual result was -$80.3 million, up 34.77% from the prior year.
- EBITDA came in at -$44.6 million for Q1 2026 at Zymeworks, down from -$41.2 million in the prior quarter.
- In the past five years, EBITDA ranged from a high of $309.4 million in Q4 2022 to a low of -$72.6 million in Q1 2022.
- The 5-year median for EBITDA is -$29.2 million (2023), against an average of -$14.2 million.
- Across the five-year window, EBITDA surged 890.33% in 2022 and sank 104.13% in 2023, its largest moves.
- Zymeworks' EBITDA stood at $309.4 million in 2022, then tumbled by 104.13% to -$12.8 million in 2023, then tumbled by 91.28% to -$24.5 million in 2024, then tumbled by 68.6% to -$41.2 million in 2025, then declined by 8.27% to -$44.6 million in 2026.
- The last three EBITDA figures came in at -$44.6 million (Q1 2026), -$41.2 million (Q4 2025), and -$19.3 million (Q3 2025), per Business Quant data.
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | EBITDA (Qtr) |
|---|---|---|---|---|---|
| 1 | Alterity Therapeutics | 925,601.88 Bn | 925,601.85 Bn | - | - |
| 2 | Belite Bio | 58,560.00 Bn | 58,560.00 Bn | - | -26.92 Mn |
| 3 | Quantum Biopharma | 17,284.41 Bn | 17,284.40 Bn | - | -13.63 Mn |
| 4 | Legend Biotech | 2,809.00 Bn | 2,808.71 Bn | 242.10 Mn | -19.70 Mn |
| 5 | Evaxion A | 1,334.43 Bn | 1,334.42 Bn | - | -3.82 Mn |
| 6 | Akari Therapeutics | 1,312.27 Bn | 1,312.26 Bn | - | -14.44 Mn |
| 7 | Psyence Biomedical | 212.16 Bn | 212.16 Bn | - | -752,618.00 |
| 8 | Vertex Pharmaceuticals | 114.83 Bn | 107.58 Bn | 2.59 Bn | 1.14 Bn |
| 9 | Abivax | 91.96 Bn | 91.96 Bn | - | -65.83 Mn |
| 10 | Zymeworks | 1.73 Bn | 1.36 Bn | - | -44.65 Mn |
Historic Data
Download Data| Date | Value |
|---|---|
| Mar 31, 2026 | -44.65 Mn |
| Dec 31, 2025 | -41.24 Mn |
| Sep 30, 2025 | -19.31 Mn |
| Jun 30, 2025 | 2.38 Mn |
| Mar 31, 2025 | -22.09 Mn |
| Dec 31, 2024 | -24.46 Mn |
| Sep 30, 2024 | -27.95 Mn |
| Jun 30, 2024 | -37.87 Mn |
| Mar 31, 2024 | -32.77 Mn |
| Dec 31, 2023 | -12.79 Mn |
| Sep 30, 2023 | -29.17 Mn |
| Jun 30, 2023 | -53.03 Mn |
| Mar 31, 2023 | -23.63 Mn |
| Dec 31, 2022 | 309.43 Mn |
| Sep 30, 2022 | -47.85 Mn |
| Jun 30, 2022 | -64.62 Mn |
| Mar 31, 2022 | -72.63 Mn |
| Dec 31, 2021 | -39.15 Mn |
| Sep 30, 2021 | -60.58 Mn |