111 (YI) Research & Development (2017 - 2025)

111's (YI) quarterly Research & Development came in at -$2.1 million in Q4 2025, little changed year-on-year from -$2.1 million in Q4 2024, and up 1.68% quarter-over-quarter from -$2.1 million in Q3 2025.

111 (YI) Research & Development (2017 - 2025) Analysis & Trends

111 has disclosed Research & Development across 9 years of filings, most recently posting -$2.1 million for Q4 2025.

  • Research & Development for Q4 2025 came in at -$2.1 million, changed 0.05% year-over-year; the trailing twelve-month figure through Dec 2025 was -$8.5 million (up 12.5% YoY), and the FY2025 annual result was $8.6 million, down 9.48% from the prior year.
  • Research & Development came in at -$2.1 million for Q4 2025 at 111, up from -$2.1 million in the prior quarter.
  • In the past five years, Research & Development ranged from a high of -$2.1 million in Q2 2025 to a low of -$8.7 million in Q3 2021.
  • The 5-year median for Research & Development is -$3.6 million (2023), against an average of -$4.3 million.
  • Across the five-year window, Research & Development plunged 212.98% in 2021 and surged 69.47% in 2024, its largest moves.
  • 111's Research & Development stood at -$4.8 million in 2021, then dropped by 11.39% to -$5.4 million in 2022, then retreated by 28.1% to -$6.9 million in 2023, then soared by 69.47% to -$2.1 million in 2024, then decreased by 0.05% to -$2.1 million in 2025.
  • The last three Research & Development figures came in at -$2.1 million (Q4 2025), -$2.1 million (Q3 2025), and -$2.1 million (Q2 2025), per Business Quant data.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) R&D (Qtr)
1 Akso Health 2,315,158.81 Bn 2,315,158.63 Bn - -
2 Mckesson 92.76 Bn 89.18 Bn 4.04 Bn -
3 Cencora 52.82 Bn 50.83 Bn 3.59 Bn -
4 Cardinal Health 52.17 Bn 48.39 Bn 2.50 Bn -
5 Henry Schein 9.19 Bn 9.71 Bn 1.07 Bn -
6 Accendra Health 246.88 Mn -90.00 Mn 312.39 Mn -
7 Edap Tms 161.92 Mn 146.92 Mn 8.15 Mn 2.60 Mn
8 111 107.47 Mn 25.61 Mn 23.58 Mn -2.11 Mn
9 Cosmos Health 9.42 Mn 7.26 Mn 1.38 Mn -
10 Cellyan Biotechnology 5.69 -2.48 Mn - -

Historic Data

Download Data
DateValue
Dec 31, 2025 -2.11 Mn
Sep 30, 2025 -2.15 Mn
Jun 30, 2025 -2.08 Mn
Mar 31, 2025 -2.13 Mn
Dec 31, 2024 -2.11 Mn
Sep 30, 2024 -2.50 Mn
Jun 30, 2024 -2.53 Mn
Mar 31, 2024 -2.54 Mn
Dec 31, 2023 -6.92 Mn
Sep 30, 2023 -3.48 Mn
Jun 30, 2023 -3.38 Mn
Mar 31, 2023 -3.69 Mn
Dec 31, 2022 -5.40 Mn
Sep 30, 2022 -4.15 Mn
Jun 30, 2022 -5.03 Mn
Mar 31, 2022 -6.16 Mn
Dec 31, 2021 -4.85 Mn
Sep 30, 2021 -8.70 Mn
Jun 30, 2021 -8.15 Mn
Mar 31, 2021 -7.59 Mn