111 (YI) Gross Margin (2017 - 2025)

111 (YI) posted Gross Margin of 5.85% for Q4 2025, down 1.45% sequentially from 5.93% in Q3 2025, and up 58.0% YoY from 3.7% in Q4 2024.

111 (YI) Gross Margin (2017 - 2025) Analysis & Trends

111 has reported Gross Margin for 9 years, with the latest figure at 5.85% in Q4 2025.

Quarterly Gross Margin rose 58.0% year-over-year to 5.85% in Q4 2025, while the trailing twelve-month figure through Dec 2025 was 5.75% (down 1.0% YoY) and the FY2025 annual result came in at 5.61%, down 15.0% from the prior year.
Gross Margin fell to 5.85% in Q4 2025 per YI's latest filing, from 5.93% in the prior quarter.
Over five years, Gross Margin peaked at 6.45% in Q1 2022 and troughed at 4.45% in Q2 2021.
A 5-year average of 5.68% and a median of 5.88% in 2024 frame the typical range for Gross Margin.
The widest YoY moves for Gross Margin: up 200 bps in 2021, down 105 bps in 2021.
Over 5 years, Gross Margin stood at 5.91% in 2021, then advanced by 3 bps to 6.11% in 2022, then retreated by 15 bps to 5.21% in 2023, then climbed by 1 bps to 5.26% in 2024, then advanced by 11 bps to 5.85% in 2025.
According to Business Quant data, Gross Margin over the past three periods registered 5.85%, 5.93%, and 5.73% for Q4 2025, Q3 2025, and Q2 2025 respectively.

#	Company	Market Cap	Enterprise Value	Gross Profit (Qtr)	Gross Margin (Qtr)
1	Mckesson	101.96 Bn	96.80 Bn	3.69 Bn	3.50%
2	Cencora	61.51 Bn	58.69 Bn	3.61 Bn	4.26%
3	Cardinal Health	54.44 Bn	49.58 Bn	2.56 Bn	4.02%
4	Henry Schein	10.05 Bn	9.89 Bn	1.10 Bn	31.84%
5	Akso Health	820.26 Mn	820.04 Mn	-	-
6	Edap Tms	157.62 Mn	136.08 Mn	7.34 Mn	55.58%
7	Accendra Health	96.64 Mn	88.98 Mn	263.41 Mn	42.95%
8	111	30.87 Mn	109.39 Mn	18.18 Mn	5.31%
9	Cosmos Health	13.39 Mn	10.94 Mn	1.51 Mn	7.96%
10	VitaNova Life Sciences	11.51 Mn	9.91 Mn	264,662.00	14.83%

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