X4 Pharmaceuticals (XFOR) Return on Capital Employed (2018 - 2025)

X4 Pharmaceuticals (XFOR) reported Return on Capital Employed of 43.17% for Q4 2025, down 1505.0% on a YoY basis from 3.07% in Q4 2024, and up 51.61% quarter-over-quarter from 89.21% in Q3 2025.

X4 Pharmaceuticals (XFOR) Return on Capital Employed (2018 - 2025) Analysis & Trends

X4 Pharmaceuticals has reported Return on Capital Employed for 8 years, with the latest figure at 43.17% in Q4 2025.

  • For the quarter ending Q4 2025, Return on Capital Employed fell 1505.0% year-over-year to 43.17%; the trailing twelve-month figure through Dec 2025 stood at 43.17% (down 1505.0% YoY), and the FY2025 full-year result was 45.09%, down 1315.0% from the prior year.
  • Return on Capital Employed for Q4 2025 stood at 43.17%, up from 89.21% in the prior quarter.
  • The five-year high for Return on Capital Employed was 7.61% in Q1 2025, with the low at 132.92% in Q3 2022.
  • Historically, Return on Capital Employed has averaged 70.72% across 5 years, with a median of 78.16% in 2022.
  • The largest YoY upside for Return on Capital Employed was 10117 bps in 2025 against a maximum downside of 9779 bps in 2025.
  • X4 Pharmaceuticals' Return on Capital Employed stood at 81.19% in 2021, then advanced by 4 bps to 78.07% in 2022, then declined by 0 bps to 78.25% in 2023, then jumped by 64 bps to 28.12% in 2024, then sank by 54 bps to 43.17% in 2025.
  • The last three Return on Capital Employed figures came in at 43.17% (Q4 2025), 89.21% (Q3 2025), and 111.82% (Q2 2025), per Business Quant data.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) ROCE (Qtr)
1 Alterity Therapeutics 788,338.31 Bn 788,338.28 Bn - -
2 Belite Bio 56,560.00 Bn 56,560.00 Bn - -
3 Quantum Biopharma 17,329.30 Bn 17,329.30 Bn - 450.31%
4 Legend Biotech 3,341.00 Bn 3,340.71 Bn 242.10 Mn 51.73%
5 Akari Therapeutics 1,727.91 Bn 1,727.91 Bn - -107.40%
6 Evaxion A 1,536.68 Bn 1,536.67 Bn - -
7 Psyence Biomedical 238.34 Bn 238.33 Bn - -
8 Vertex Pharmaceuticals 113.42 Bn 106.17 Bn 2.59 Bn 21.10%
9 Abivax 95.45 Bn 95.45 Bn - -50.43%
10 X4 Pharmaceuticals 166.63 Mn 166.63 Mn 2.20 Mn -43.17%

Historic Data

Download Data
DateValue
Dec 31, 2025 -43.17%
Sep 30, 2025 -89.21%
Jun 30, 2025 -111.82%
Mar 31, 2025 -7.61%
Dec 31, 2024 -28.12%
Sep 30, 2024 -15.68%
Jun 30, 2024 -14.04%
Mar 31, 2024 -108.79%
Dec 31, 2023 -78.25%
Sep 30, 2023 -72.95%
Jun 30, 2023 -79.62%
Mar 31, 2023 -79.33%
Dec 31, 2022 -78.07%
Sep 30, 2022 -132.92%
Jun 30, 2022 -131.75%
Mar 31, 2022 -94.66%
Dec 31, 2021 -81.19%
Sep 30, 2021 -62.54%
Jun 30, 2021 -51.78%
Mar 31, 2021 -52.82%