X4 Pharmaceuticals (XFOR) Return on Capital Employed (2018 - 2025)
X4 Pharmaceuticals (XFOR) reported Return on Capital Employed of 43.17% for Q4 2025, down 1505.0% on a YoY basis from 3.07% in Q4 2024, and up 51.61% quarter-over-quarter from 89.21% in Q3 2025.
X4 Pharmaceuticals (XFOR) Return on Capital Employed (2018 - 2025) Analysis & Trends
X4 Pharmaceuticals has reported Return on Capital Employed for 8 years, with the latest figure at 43.17% in Q4 2025.
- For the quarter ending Q4 2025, Return on Capital Employed fell 1505.0% year-over-year to 43.17%; the trailing twelve-month figure through Dec 2025 stood at 43.17% (down 1505.0% YoY), and the FY2025 full-year result was 45.09%, down 1315.0% from the prior year.
- Return on Capital Employed for Q4 2025 stood at 43.17%, up from 89.21% in the prior quarter.
- The five-year high for Return on Capital Employed was 7.61% in Q1 2025, with the low at 132.92% in Q3 2022.
- Historically, Return on Capital Employed has averaged 70.72% across 5 years, with a median of 78.16% in 2022.
- The largest YoY upside for Return on Capital Employed was 10117 bps in 2025 against a maximum downside of 9779 bps in 2025.
- X4 Pharmaceuticals' Return on Capital Employed stood at 81.19% in 2021, then advanced by 4 bps to 78.07% in 2022, then declined by 0 bps to 78.25% in 2023, then jumped by 64 bps to 28.12% in 2024, then sank by 54 bps to 43.17% in 2025.
- The last three Return on Capital Employed figures came in at 43.17% (Q4 2025), 89.21% (Q3 2025), and 111.82% (Q2 2025), per Business Quant data.
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | ROCE (Qtr) |
|---|---|---|---|---|---|
| 1 | Alterity Therapeutics | 788,338.31 Bn | 788,338.28 Bn | - | - |
| 2 | Belite Bio | 56,560.00 Bn | 56,560.00 Bn | - | - |
| 3 | Quantum Biopharma | 17,329.30 Bn | 17,329.30 Bn | - | 450.31% |
| 4 | Legend Biotech | 3,341.00 Bn | 3,340.71 Bn | 242.10 Mn | 51.73% |
| 5 | Akari Therapeutics | 1,727.91 Bn | 1,727.91 Bn | - | -107.40% |
| 6 | Evaxion A | 1,536.68 Bn | 1,536.67 Bn | - | - |
| 7 | Psyence Biomedical | 238.34 Bn | 238.33 Bn | - | - |
| 8 | Vertex Pharmaceuticals | 113.42 Bn | 106.17 Bn | 2.59 Bn | 21.10% |
| 9 | Abivax | 95.45 Bn | 95.45 Bn | - | -50.43% |
| 10 | X4 Pharmaceuticals | 166.63 Mn | 166.63 Mn | 2.20 Mn | -43.17% |
Historic Data
Download Data| Date | Value |
|---|---|
| Dec 31, 2025 | -43.17% |
| Sep 30, 2025 | -89.21% |
| Jun 30, 2025 | -111.82% |
| Mar 31, 2025 | -7.61% |
| Dec 31, 2024 | -28.12% |
| Sep 30, 2024 | -15.68% |
| Jun 30, 2024 | -14.04% |
| Mar 31, 2024 | -108.79% |
| Dec 31, 2023 | -78.25% |
| Sep 30, 2023 | -72.95% |
| Jun 30, 2023 | -79.62% |
| Mar 31, 2023 | -79.33% |
| Dec 31, 2022 | -78.07% |
| Sep 30, 2022 | -132.92% |
| Jun 30, 2022 | -131.75% |
| Mar 31, 2022 | -94.66% |
| Dec 31, 2021 | -81.19% |
| Sep 30, 2021 | -62.54% |
| Jun 30, 2021 | -51.78% |
| Mar 31, 2021 | -52.82% |