X4 Pharmaceuticals (XFOR) EBITDA (2017 - 2025)

X4 Pharmaceuticals posted quarterly EBITDA of -$23.7 million for Q4 2025, up 33.64% year-on-year from -$17.7 million in Q4 2024, and up 13.85% on a QoQ basis from -$27.5 million in Q3 2025.

X4 Pharmaceuticals (XFOR) has 9 years of EBITDA data on file, last reported at -$23.7 million in Q4 2025.

  • For the quarter ending Q4 2025, EBITDA rose 33.64% year-over-year to -$23.7 million; the trailing twelve-month figure through Dec 2025 stood at -$86.9 million (down 138.68% YoY), and the FY2025 full-year result was -$86.9 million, down 131.98% from the prior year.
  • EBITDA for Q4 2025 stood at -$23.7 million, up from -$27.5 million in the prior quarter.
  • Across five years, EBITDA topped out at $71.1 million in Q2 2024 and bottomed at -$37.3 million in Q1 2024.
  • The 5-year median for EBITDA is -$25.4 million (2022), against an average of -$20.2 million.
  • The widest annual swing landed in 2024, when EBITDA surged 375.54%; it then plunged 136.89% in 2025.
  • A 5-year view of EBITDA shows it stood at -$29.1 million in 2021, then increased by 11.97% to -$25.6 million in 2022, then increased by 1.48% to -$25.2 million in 2023, then plunged by 41.73% to -$35.7 million in 2024, then jumped by 33.64% to -$23.7 million in 2025.
  • The last three EBITDA figures came in at -$23.7 million (Q4 2025), -$27.5 million (Q3 2025), and -$26.2 million (Q2 2025), per Business Quant data.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) EBITDA (Qtr)
1 Quantum Biopharma 1,216,509.61 Bn 1,216,509.61 Bn - -13.63 Mn
2 Alterity Therapeutics 764,224.41 Bn 764,224.38 Bn - -
3 Legend Biotech 2,716.00 Bn 2,715.71 Bn 242.10 Mn -19.70 Mn
4 Nanobiotix 2,248.83 Bn 2,248.77 Bn - -
5 Akari Therapeutics 1,951.18 Bn 1,951.17 Bn - -14.44 Mn
6 Vertex Pharmaceuticals 113.69 Bn 106.44 Bn 2.59 Bn 1.14 Bn
7 Evaxion A 64.16 Bn 64.14 Bn - -3.82 Mn
8 Regeneron Pharmaceuticals 63.94 Bn 55.18 Bn 3.31 Bn 661.60 Mn
9 Alnylam Pharmaceuticals 40.13 Bn 37.12 Bn 959.66 Mn 201.19 Mn
10 X4 Pharmaceuticals 182.28 Mn 182.28 Mn 2.20 Mn -23.70 Mn

Historic Data

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DateValue
Dec 31, 2025 -23.70 Mn
Sep 30, 2025 -27.51 Mn
Jun 30, 2025 -26.23 Mn
Mar 31, 2025 -9.44 Mn
Dec 31, 2024 -35.72 Mn
Sep 30, 2024 -34.50 Mn
Jun 30, 2024 71.10 Mn
Mar 31, 2024 -37.29 Mn
Dec 31, 2023 -25.20 Mn
Sep 30, 2023 -27.21 Mn
Jun 30, 2023 -25.81 Mn
Mar 31, 2023 -29.30 Mn
Dec 31, 2022 -25.58 Mn
Sep 30, 2022 -20.15 Mn
Jun 30, 2022 -20.57 Mn
Mar 31, 2022 -21.27 Mn
Dec 31, 2021 -29.06 Mn
Sep 30, 2021 -19.12 Mn
Jun 30, 2021 -19.00 Mn
Mar 31, 2021 -17.94 Mn
Dec 31, 2020 -18.40 Mn
Sep 30, 2020 -17.45 Mn
Jun 30, 2020 -15.14 Mn
Mar 31, 2020 -11.14 Mn
Dec 31, 2019 -10.84 Mn
Sep 30, 2019 -17.79 Mn
Jun 30, 2019 -13.45 Mn
Mar 31, 2019 -10.85 Mn
Dec 31, 2018 -8.05 Mn
Sep 30, 2018 -8.55 Mn
Jun 30, 2018 -6.38 Mn
Mar 31, 2018 -6.11 Mn
Dec 31, 2017 2.28 Mn
Sep 30, 2017 -13.06 Mn
Jun 30, 2017 -5.64 Mn
Mar 31, 2017 -5.83 Mn