Spyre Therapeutics (SYRE) Times Interest Earned (2015 - 2026)
Spyre Therapeutics (SYRE) posted Times Interest Earned of -$43.18 for Q1 2026, up 91.24% on a QoQ basis from -$492.86 in Q4 2025, and up 87.02% year-over-year from -$23.09 in Q1 2025.
Spyre Therapeutics (SYRE) Times Interest Earned (2015 - 2026) Analysis & Trends
Spyre Therapeutics' Times Interest Earned history runs 12 years deep, the most recent figure standing at -$43.18 for Q1 2026.
- Quarterly Times Interest Earned rose 87.02% year-over-year to -$43.18 in Q1 2026, while the trailing twelve-month figure through Mar 2026 was -$190.76 (up 85.67% YoY) and the FY2025 annual result came in at -$1.04, up 18.69% from the prior year.
- Times Interest Earned was -$43.18 for Q1 2026 at Spyre Therapeutics, up from -$492.86 in the prior quarter.
- Across five years, Times Interest Earned topped out at -$0.37 in Q4 2023 and bottomed at -$2769.6 in Q3 2024.
- A 5-year average of -$418.73 and a median of -$154.69 in 2022 frame the typical range for Times Interest Earned.
- Annual changes were most pronounced in 2023 — Times Interest Earned jumped 99.64% — and 2025, when it plunged 130998.11%.
- Spyre Therapeutics' Times Interest Earned stood at -$100.85 in 2022, then soared by 99.64% to -$0.37 in 2023, then decreased by 2.75% to -$0.38 in 2024, then plunged by 130998.11% to -$492.86 in 2025, then jumped by 91.24% to -$43.18 in 2026.
- Business Quant data shows SYRE's Times Interest Earned at -$43.18 in Q1 2026, -$492.86 in Q4 2025, and -$1497.1 in Q3 2025.
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Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Times Interest Earned (Qtr) |
|---|---|---|---|---|---|
| 1 | Oculis Holding AG | 68,785.72 Bn | 68,785.72 Bn | - | 658.42 |
| 2 | Nanobiotix | 1,895.57 Bn | 1,895.51 Bn | - | - |
| 3 | BeOne Medicines | 471.35 Bn | 466.56 Bn | 1.35 Bn | 7.60 |
| 4 | NuCana | 279.75 Bn | 279.75 Bn | - | -0.22 |
| 5 | Vertex Pharmaceuticals | 120.24 Bn | 113.00 Bn | 2.59 Bn | 2.71 |
| 6 | Regeneron Pharmaceuticals | 67.80 Bn | 59.04 Bn | 3.31 Bn | 22.72 |
| 7 | Belite Bio | 62.51 Bn | 62.51 Bn | - | - |
| 8 | Argenx Se | 57.38 Bn | 57.38 Bn | 1.41 Bn | - |
| 9 | Revolution Medicines | 37.78 Bn | 37.78 Bn | - | -0.38 |
| 10 | Spyre Therapeutics | 257.83 Mn | 257.83 Mn | - | -43.18 |
Historic Data
Download Data| Date | Value |
|---|---|
| Mar 31, 2026 | -43.18 |
| Dec 31, 2025 | -492.86 |
| Sep 30, 2025 | -1,497.05 |
| Jun 30, 2025 | -274.08 |
| Mar 31, 2025 | -332.71 |
| Dec 31, 2024 | -0.38 |
| Sep 30, 2024 | -2,769.60 |
| Jun 30, 2024 | -65.60 |
| Mar 31, 2024 | -105.93 |
| Dec 31, 2023 | -0.37 |
| Sep 30, 2023 | -159.45 |
| Dec 31, 2022 | -100.85 |
| Sep 30, 2022 | -161.68 |
| Jun 30, 2022 | -122.53 |
| Mar 31, 2022 | -154.69 |
| Dec 31, 2021 | -62.32 |
| Sep 30, 2021 | -1,193.71 |
| Jun 30, 2021 | -372.50 |
| Mar 31, 2021 | -18,209.00 |
| Dec 31, 2020 | -6.01 |