SOPHiA GENETICS (SOPH) Net Margin (2020 - 2025)
SOPHiA GENETICS recorded quarterly Net Margin of 91.99% in Q4 2025, up 4.45% quarter-over-quarter from 96.27% in Q3 2025, and down 1346.0% year-over-year from 7.38% in Q4 2024.
SOPHiA GENETICS's Net Margin history runs 6 years deep, the most recent figure standing at 91.99% for Q4 2025.
- In Q4 2025, Net Margin fell 1346.0% year-over-year to 91.99%; the TTM figure through Dec 2025 stood at 98.32% (down 619.0% YoY), while the FY2025 annual figure was 98.32%, down 619.0% from the prior year.
- Net Margin came in at 91.99% for Q4 2025 at SOPHiA GENETICS, up from 96.27% in the prior quarter.
- In the past five years, Net Margin ranged from a high of 78.53% in Q4 2024 to a low of 230.37% in Q1 2022.
- A 5-year average of 136.88% and a median of 125.95% in 2021 frame the typical range for Net Margin.
- Across the five-year window, Net Margin jumped 38572 bps in 2021 and plunged 9314 bps in 2022, its largest moves.
- SOPHiA GENETICS's Net Margin stood at 205.03% in 2021, then soared by 47 bps to 108.23% in 2022, then sank by 30 bps to 141.13% in 2023, then jumped by 44 bps to 78.53% in 2024, then dropped by 17 bps to 91.99% in 2025.
- According to Business Quant data, Net Margin over the past three periods registered 91.99%, 96.27%, and 114.01% for Q4 2025, Q3 2025, and Q2 2025 respectively.
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Net Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Veeva Systems | 30.85 Bn | 24.28 Bn | 622.47 Mn | 29.21% |
| 2 | BrightSpring Health Services | 12.29 Bn | 11.41 Bn | 482.22 Mn | 2.06% |
| 3 | Healthequity | 7.80 Bn | 7.48 Bn | 256.31 Mn | 19.57% |
| 4 | Hinge Health | 4.82 Bn | 4.51 Bn | 154.23 Mn | 18.66% |
| 5 | Doximity | 4.21 Bn | 3.46 Bn | 125.97 Mn | 13.15% |
| 6 | Waystar Holding | 4.18 Bn | 4.03 Bn | 268.04 Mn | 13.80% |
| 7 | 10x Genomics | 3.78 Bn | 3.24 Bn | 106.18 Mn | -8.93% |
| 8 | Privia Health | 2.65 Bn | 2.28 Bn | 595.71 Mn | 0.61% |
| 9 | Omnicell | 1.95 Bn | 1.78 Bn | 140.36 Mn | 3.68% |
| 10 | SOPHiA GENETICS | 24.12 Mn | -46.17 Mn | 14.69 Mn | -91.99% |
Historic Data
Download Data| Date | Value |
|---|---|
| Dec 31, 2025 | -91.99% |
| Sep 30, 2025 | -96.27% |
| Jun 30, 2025 | -114.01% |
| Mar 31, 2025 | -92.13% |
| Dec 31, 2024 | -78.53% |
| Sep 30, 2024 | -114.67% |
| Jun 30, 2024 | -94.07% |
| Mar 31, 2024 | -82.84% |
| Dec 31, 2023 | -141.13% |
| Sep 30, 2023 | -81.13% |
| Jun 30, 2023 | -141.16% |
| Mar 31, 2023 | -139.52% |
| Dec 31, 2022 | -108.23% |
| Sep 30, 2022 | -201.92% |
| Jun 30, 2022 | -211.65% |
| Mar 31, 2022 | -230.37% |
| Dec 31, 2021 | -205.03% |
| Sep 30, 2021 | -195.84% |
| Jun 30, 2021 | -179.90% |
| Mar 31, 2021 | -137.23% |
| Dec 31, 2020 | -590.75% |
| Sep 30, 2020 | -146.12% |
| Jun 30, 2020 | -132.17% |