SOPHiA GENETICS (SOPH) Net Margin (2020 - 2025)
SOPHiA GENETICS's (SOPH) quarterly Net Margin came in at 91.99% in Q4 2025, down 1346.0% year-on-year from 7.38% in Q4 2024, and up 4.45% quarter-over-quarter from 96.27% in Q3 2025.
SOPHiA GENETICS (SOPH) Net Margin (2020 - 2025) Analysis & Trends
SOPHiA GENETICS has disclosed Net Margin across 6 years of filings, most recently posting 91.99% for Q4 2025.
- Net Margin for Q4 2025 came in at 91.99%, down 1346.0% year-over-year; the trailing twelve-month figure through Dec 2025 was 98.32% (down 619.0% YoY), and the FY2025 annual result was 98.32%, down 619.0% from the prior year.
- Net Margin came in at 91.99% for Q4 2025 at SOPHiA GENETICS, up from 96.27% in the prior quarter.
- In the past five years, Net Margin ranged from a high of 78.53% in Q4 2024 to a low of 230.37% in Q1 2022.
- The 5-year median for Net Margin is 125.95% (2021), against an average of 136.88%.
- Across the five-year window, Net Margin sank 9314 bps in 2022 and jumped 12080 bps in 2023, its largest moves.
- SOPHiA GENETICS's Net Margin stood at 205.03% in 2021, then surged by 47 bps to 108.23% in 2022, then slumped by 30 bps to 141.13% in 2023, then soared by 44 bps to 78.53% in 2024, then slipped by 17 bps to 91.99% in 2025.
- The last three Net Margin figures came in at 91.99% (Q4 2025), 96.27% (Q3 2025), and 114.01% (Q2 2025), per Business Quant data.
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Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Net Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Veeva Systems | 24.83 Bn | 17.52 Bn | 662.02 Mn | 29.55% |
| 2 | BrightSpring Health Services | 13.57 Bn | 12.69 Bn | 482.22 Mn | 2.06% |
| 3 | Healthequity | 7.20 Bn | 6.93 Bn | 256.31 Mn | 19.57% |
| 4 | Hinge Health | 5.42 Bn | 5.11 Bn | 154.23 Mn | 18.66% |
| 5 | 10x Genomics | 4.46 Bn | 3.92 Bn | 106.18 Mn | -8.93% |
| 6 | Doximity | 3.81 Bn | 3.06 Bn | 125.97 Mn | 13.15% |
| 7 | Waystar Holding | 3.52 Bn | 3.36 Bn | 268.04 Mn | 13.80% |
| 8 | Privia Health | 2.94 Bn | 2.57 Bn | 595.71 Mn | 0.61% |
| 9 | Omnicell | 1.76 Bn | 1.59 Bn | 140.36 Mn | 3.68% |
| 10 | SOPHiA GENETICS | 26.19 Mn | -44.10 Mn | 14.69 Mn | -91.99% |
Historic Data
Download Data| Date | Value |
|---|---|
| Dec 31, 2025 | -91.99% |
| Sep 30, 2025 | -96.27% |
| Jun 30, 2025 | -114.01% |
| Mar 31, 2025 | -92.13% |
| Dec 31, 2024 | -78.53% |
| Sep 30, 2024 | -114.67% |
| Jun 30, 2024 | -94.07% |
| Mar 31, 2024 | -82.84% |
| Dec 31, 2023 | -141.13% |
| Sep 30, 2023 | -81.13% |
| Jun 30, 2023 | -141.16% |
| Mar 31, 2023 | -139.52% |
| Dec 31, 2022 | -108.23% |
| Sep 30, 2022 | -201.92% |
| Jun 30, 2022 | -211.65% |
| Mar 31, 2022 | -230.37% |
| Dec 31, 2021 | -205.03% |
| Sep 30, 2021 | -195.84% |
| Jun 30, 2021 | -179.90% |
| Mar 31, 2021 | -137.23% |