SOPHiA GENETICS (SOPH) Net Margin (2020 - 2025)
SOPHiA GENETICS (SOPH) reported Net Margin of 88.35% for Q4 2025, down 287.0% on a YoY basis from 47.25% in Q4 2024, and up 14.11% sequentially from 102.87% in Q3 2025.
SOPHiA GENETICS (SOPH) Net Margin (2020 - 2025) Analysis & Trends
SOPHiA GENETICS (SOPH) has 6 years of Net Margin data on file, last reported at 88.35% in Q4 2025.
- For the quarter ending Q4 2025, Net Margin fell 287.0% year-over-year to 88.35%; the trailing twelve-month figure through Dec 2025 stood at 44.22% (up 504.0% YoY), and the FY2025 full-year result was 102.24%, down 635.0% from the prior year.
- Net Margin grew to 88.35% in Q4 2025, from 102.87% in the prior quarter.
- In the past five years, Net Margin ranged from a high of 211.55% in Q2 2022 to a low of 234.67% in Q1 2022.
- A 5-year average of 81.7% and a median of 103.63% in 2022 frame the typical range for Net Margin.
- Across the five-year window, Net Margin plunged 32920 bps in 2021 and surged 39223 bps in 2022, its largest moves.
- Tracing SOPH's Net Margin over 5 years: stood at 195.43% in 2021, then jumped by 47 bps to 104.39% in 2022, then plunged by 35 bps to 141.13% in 2023, then soared by 39 bps to 85.48% in 2024, then decreased by 3 bps to 88.35% in 2025.
- Business Quant data shows SOPH's Net Margin at 88.35% in Q4 2025, 102.87% in Q3 2025, and 122.33% in Q2 2025.
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Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Net Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Veeva Systems | 31.91 Bn | 24.60 Bn | 662.02 Mn | 29.55% |
| 2 | BrightSpring Health Services | 14.61 Bn | 13.71 Bn | 482.22 Mn | 4.12% |
| 3 | Healthequity | 8.29 Bn | 8.03 Bn | 256.31 Mn | 19.57% |
| 4 | Hinge Health | 5.96 Bn | 5.65 Bn | 154.23 Mn | 18.66% |
| 5 | 10x Genomics | 5.83 Bn | 5.29 Bn | 106.18 Mn | -8.93% |
| 6 | MiniMed | 4.49 Bn | 4.19 Bn | 480.00 Mn | -22.10% |
| 7 | Waystar Holding | 4.49 Bn | 4.42 Bn | 216.84 Mn | 13.79% |
| 8 | Doximity | 3.98 Bn | 3.23 Bn | 125.97 Mn | 13.15% |
| 9 | Privia Health | 3.17 Bn | 2.75 Bn | - | 0.61% |
| 10 | SOPHiA GENETICS | 392.95 Mn | 322.66 Mn | 14.69 Mn | -88.35% |
Historic Data
Download Data| Date | Value |
|---|---|
| Dec 31, 2025 | -88.35% |
| Sep 30, 2025 | -102.87% |
| Jun 30, 2025 | 122.33% |
| Mar 31, 2025 | -97.78% |
| Dec 31, 2024 | -85.48% |
| Sep 30, 2024 | -116.31% |
| Jun 30, 2024 | 96.11% |
| Mar 31, 2024 | -86.85% |
| Dec 31, 2023 | -141.13% |
| Sep 30, 2023 | -84.79% |
| Jun 30, 2023 | 142.13% |
| Mar 31, 2023 | -141.06% |
| Dec 31, 2022 | -104.39% |
| Sep 30, 2022 | -200.12% |
| Jun 30, 2022 | 211.55% |
| Mar 31, 2022 | -234.67% |
| Dec 31, 2021 | -195.43% |
| Sep 30, 2021 | -205.07% |
| Jun 30, 2021 | -180.68% |
| Mar 31, 2021 | -141.13% |