SOPHiA GENETICS (SOPH) Net Margin (2020 - 2025)
SOPHiA GENETICS (SOPH) posted Net Margin of 88.35% for Q4 2025, up 14.11% sequentially from 102.87% in Q3 2025, and down 287.0% YoY from 47.25% in Q4 2024.
SOPHiA GENETICS (SOPH) Net Margin (2020 - 2025) Analysis & Trends
SOPHiA GENETICS has reported Net Margin for 6 years, with the latest figure at 88.35% in Q4 2025.
- Quarterly Net Margin fell 287.0% year-over-year to 88.35% in Q4 2025, while the trailing twelve-month figure through Dec 2025 was 44.22% (up 504.0% YoY) and the FY2025 annual result came in at 102.24%, down 635.0% from the prior year.
- Net Margin grew to 88.35% in Q4 2025 per SOPH's latest filing, from 102.87% in the prior quarter.
- Over five years, Net Margin peaked at 211.55% in Q2 2022 and troughed at 234.67% in Q1 2022.
- A 5-year average of 81.7% and a median of 103.63% in 2022 frame the typical range for Net Margin.
- The widest YoY moves for Net Margin: up 2000000000 bps in 2021, down 32920 bps in 2021.
- Over 5 years, Net Margin stood at 195.43% in 2021, then jumped by 47 bps to 104.39% in 2022, then tumbled by 35 bps to 141.13% in 2023, then soared by 39 bps to 85.48% in 2024, then declined by 3 bps to 88.35% in 2025.
- According to Business Quant data, Net Margin over the past three periods registered 88.35%, 102.87%, and 122.33% for Q4 2025, Q3 2025, and Q2 2025 respectively.
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Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Net Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Veeva Systems | 39.72 Bn | 32.40 Bn | 662.02 Mn | 29.55% |
| 2 | BrightSpring Health Services | 12.19 Bn | 11.64 Bn | 492.75 Mn | 2.18% |
| 3 | Healthequity | 8.79 Bn | 8.52 Bn | 256.31 Mn | 19.57% |
| 4 | 10x Genomics | 7.31 Bn | 6.76 Bn | 112.50 Mn | -11.87% |
| 5 | Hinge Health | 7.10 Bn | 6.71 Bn | 183.95 Mn | 20.25% |
| 6 | MiniMed | 5.66 Bn | 5.36 Bn | 480.00 Mn | -22.10% |
| 7 | Waystar Holding | 4.76 Bn | 4.56 Bn | 221.99 Mn | 12.78% |
| 8 | Doximity | 4.46 Bn | 3.77 Bn | 132.93 Mn | 15.53% |
| 9 | Heartflow | 3.66 Bn | 3.28 Bn | 53.19 Mn | -24.57% |
| 10 | SOPHiA GENETICS | 553.79 Mn | 446.12 Mn | - | - |
Historic Data
Download Data| Date | Value |
|---|---|
| Dec 31, 2025 | -88.35% |
| Sep 30, 2025 | -102.87% |
| Jun 30, 2025 | 122.33% |
| Mar 31, 2025 | -97.78% |
| Dec 31, 2024 | -85.48% |
| Sep 30, 2024 | -116.31% |
| Jun 30, 2024 | 96.11% |
| Mar 31, 2024 | -86.85% |
| Dec 31, 2023 | -141.13% |
| Sep 30, 2023 | -84.79% |
| Jun 30, 2023 | 142.13% |
| Mar 31, 2023 | -141.06% |
| Dec 31, 2022 | -104.39% |
| Sep 30, 2022 | -200.12% |
| Jun 30, 2022 | 211.55% |
| Mar 31, 2022 | -234.67% |
| Dec 31, 2021 | -195.43% |
| Sep 30, 2021 | -205.07% |
| Jun 30, 2021 | -180.68% |
| Mar 31, 2021 | -141.13% |