Septerna (SEPN) Return on Sales (2023 - 2026)

Septerna's quarterly Return on Sales came in at 0.0% in Q1 2026, up 98.0% year-on-year from 0.0% in Q1 2025, and up 26.8% quarter-over-quarter from 0.0% in Q4 2025.

Septerna has reported Return on Sales for 4 years, with the latest figure at 0.0% in Q1 2026.

  • For the quarter ending Q1 2026, Return on Sales rose 98.0% year-over-year to 0.0%; the trailing twelve-month figure through Mar 2026 stood at 0.0% (up 81.0% YoY), and the FY2025 full-year result was 0.01%, up 66.0% from the prior year.
  • Return on Sales for Q1 2026 stood at 0.0%, up from 0.0% in the prior quarter.
  • The five-year high for Return on Sales was 0.0% in Q3 2025, with the low at 3.32% in Q3 2023.
  • Average Return on Sales over 4 years is 1.0%, with a median of 0.97% recorded in 2024.
  • Year-over-year, Return on Sales surged 215 bps in 2024 and tumbled 164 bps in 2025.
  • Tracing SEPN's Return on Sales over 4 years: stood at 1.54% in 2023, then surged by 37 bps to 0.97% in 2024, then soared by 100 bps to 0.0% in 2025, then gained by 27 bps to 0.0% in 2026.
  • The last three Return on Sales figures came in at 0.0% (Q1 2026), 0.0% (Q4 2025), and 0.0% (Q3 2025), per Business Quant data.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) ROS (Qtr)
1 Quantum Biopharma 961,148.99 Bn 961,148.98 Bn - -
2 Alterity Therapeutics 744,933.29 Bn 744,933.26 Bn - -
3 Legend Biotech 2,540.00 Bn 2,539.71 Bn 242.10 Mn 0.00%
4 Nanobiotix 2,199.85 Bn 2,199.78 Bn - -
5 Akari Therapeutics 1,635.88 Bn 1,635.88 Bn - -
6 Vertex Pharmaceuticals 111.32 Bn 104.07 Bn 2.59 Bn 0.00%
7 Evaxion A 62.56 Bn 62.54 Bn - 0.00%
8 Regeneron Pharmaceuticals 62.55 Bn 53.79 Bn 3.31 Bn 0.00%
9 Alnylam Pharmaceuticals 39.57 Bn 36.56 Bn 959.66 Mn 0.00%
10 Septerna 1.34 Bn 1.34 Bn - 0.00%

Historic Data

Download Data 🔒
DateValue
Mar 31, 2026 0.00%
Dec 31, 2025 0.00%
Sep 30, 2025 0.00%
Jun 30, 2025 -2.09%
Mar 31, 2025 -0.98%
Dec 31, 2024 -0.97%
Sep 30, 2024 -1.17%
Jun 30, 2024 -0.45%
Mar 31, 2024 -0.45%
Dec 31, 2023 -1.54%
Sep 30, 2023 -3.32%