Septerna (SEPN) Return on Sales (2023 - 2026)

Septerna's Return on Sales history runs 4 years deep, the most recent figure standing at 0.0% for Q1 2026.

• In Q1 2026, Return on Sales rose 98.0% year-over-year to 0.0%; the TTM figure through Mar 2026 stood at 0.0% (up 81.0% YoY), while the FY2025 annual figure was 0.01%, up 66.0% from the prior year.
• Return on Sales was 0.0% for Q1 2026 at Septerna, up from 0.0% in the prior quarter.
• In the past five years, Return on Sales ranged from a high of 0.0% in Q3 2025 to a low of 3.32% in Q3 2023.
• Historically, Return on Sales has averaged 1.0% across 4 years, with a median of 0.97% in 2024.
• The sharpest annual moves came in 2024 and 2025: Return on Sales soared 215 bps in 2024, then tumbled 164 bps in 2025.
• A 4-year view of Return on Sales shows it stood at 1.54% in 2023, then jumped by 37 bps to 0.97% in 2024, then surged by 100 bps to 0.0% in 2025, then rose by 27 bps to 0.0% in 2026.
• The last three Return on Sales figures came in at 0.0% (Q1 2026), 0.0% (Q4 2025), and 0.0% (Q3 2025), per Business Quant data.