Replimune (REPL) EBT (2017 - 2025)

Replimune's (REPL) quarterly EBT came in at -$71.2 million in Q4 2025, down 8.33% year-on-year from -$77.7 million in Q4 2024, and up 13.21% quarter-over-quarter from -$82.1 million in Q3 2025.

Replimune (REPL) EBT (2017 - 2025) Analysis & Trends

Replimune has disclosed EBT across 9 years of filings, most recently posting -$71.2 million for Q4 2025.

  • EBT for Q4 2025 came in at -$71.2 million, down 8.33% year-over-year; the trailing twelve-month figure through Dec 2025 was -$314.7 million (down 38.21% YoY), and the FY2025 annual result was -$246.8 million, down 14.6% from the prior year.
  • EBT came in at -$71.2 million for Q4 2025 at Replimune, up from -$82.1 million in the prior quarter.
  • In the past five years, EBT ranged from a high of -$22.1 million in Q1 2021 to a low of -$87.2 million in Q2 2025.
  • The 5-year median for EBT is -$50.0 million (2023), against an average of -$50.8 million.
  • Across the five-year window, EBT gained 11.93% in 2024 and plunged 62.13% in 2025, its largest moves.
  • Replimune's EBT stood at -$29.6 million in 2021, then tumbled by 34.04% to -$39.7 million in 2022, then fell by 27.61% to -$50.6 million in 2023, then declined by 29.85% to -$65.8 million in 2024, then declined by 8.33% to -$71.2 million in 2025.
  • The last three EBT figures came in at -$71.2 million (Q4 2025), -$82.1 million (Q3 2025), and -$87.2 million (Q2 2025), per Business Quant data.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) EBT (Qtr)
1 Alterity Therapeutics 762,369.55 Bn 762,369.51 Bn - -
2 Belite Bio 55,096.00 Bn 55,096.00 Bn - -26.94 Mn
3 Quantum Biopharma 17,755.80 Bn 17,755.79 Bn - -2.97 Mn
4 Legend Biotech 3,486.00 Bn 3,485.71 Bn 242.10 Mn 19.60 Mn
5 Akari Therapeutics 1,737.42 Bn 1,737.41 Bn - -15.31 Mn
6 Evaxion A 1,551.28 Bn 1,551.26 Bn - -3.18 Mn
7 Psyence Biomedical 227.32 Bn 227.31 Bn - -1.50 Mn
8 Vertex Pharmaceuticals 110.84 Bn 103.59 Bn 2.59 Bn 1.25 Bn
9 Abivax 91.71 Bn 91.71 Bn - -56.48 Mn
10 Replimune 780.01 Mn 510.88 Mn - -71.24 Mn

Historic Data

Download Data
DateValue
Dec 31, 2025 -71.24 Mn
Sep 30, 2025 -82.08 Mn
Jun 30, 2025 -87.18 Mn
Mar 31, 2025 -74.24 Mn
Dec 31, 2024 -65.77 Mn
Sep 30, 2024 -53.06 Mn
Jun 30, 2024 -53.77 Mn
Mar 31, 2024 -55.14 Mn
Dec 31, 2023 -50.65 Mn
Sep 30, 2023 -60.25 Mn
Jun 30, 2023 -49.35 Mn
Mar 31, 2023 -48.95 Mn
Dec 31, 2022 -39.69 Mn
Sep 30, 2022 -43.10 Mn
Jun 30, 2022 -42.25 Mn
Mar 31, 2022 -31.86 Mn
Dec 31, 2021 -29.61 Mn
Sep 30, 2021 -29.17 Mn
Jun 30, 2021 -27.29 Mn
Mar 31, 2021 -22.09 Mn