NuCana (NCNA) Operating Income (2017 - 2025)

NuCana (NCNA) reported Operating Income of -$3.7 million for Q4 2025, down 235.47% on a YoY basis from $2.7 million in Q4 2024, and down 254.32% sequentially from -$1.1 million in Q3 2025.

NuCana (NCNA) Operating Income (2017 - 2025) Analysis & Trends

NuCana (NCNA) has 9 years of Operating Income data on file, last reported at -$3.7 million in Q4 2025.

  • For the quarter ending Q4 2025, Operating Income fell 235.47% year-over-year to -$3.7 million; the trailing twelve-month figure through Dec 2025 stood at -$24.1 million (up 16.9% YoY), and the FY2025 full-year result was -$26.5 million, up 9.06% from the prior year.
  • Operating Income retreated to -$3.7 million in Q4 2025, from -$1.1 million in the prior quarter.
  • In the past five years, Operating Income ranged from a high of -$1.1 million in Q3 2025 to a low of -$21.2 million in Q4 2021.
  • A 5-year average of -$10.4 million and a median of -$10.5 million in 2024 frame the typical range for Operating Income.
  • Across the five-year window, Operating Income jumped 90.18% in 2024 and slumped 235.47% in 2025, its largest moves.
  • Tracing NCNA's Operating Income over 5 years: stood at -$21.2 million in 2021, then grew by 4.63% to -$20.2 million in 2022, then soared by 44.13% to -$11.3 million in 2023, then jumped by 90.18% to -$1.1 million in 2024, then tumbled by 235.47% to -$3.7 million in 2025.
  • Business Quant data shows NCNA's Operating Income at -$3.7 million in Q4 2025, -$1.1 million in Q3 2025, and -$15.8 million in Q2 2025.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) Op. Inc (Qtr)
1 Oculis Holding AG 67,072.09 Bn 67,072.09 Bn - -27.75 Mn
2 Nanobiotix 1,894.61 Bn 1,894.55 Bn - -
3 Akari Therapeutics 1,014.18 Bn 1,014.18 Bn - -15.76 Mn
4 BeOne Medicines 471.64 Bn 466.85 Bn 1.35 Bn 249.90 Mn
5 Vertex Pharmaceuticals 121.72 Bn 114.47 Bn 2.59 Bn 1.14 Bn
6 Regeneron Pharmaceuticals 68.28 Bn 59.52 Bn 3.31 Bn 642.90 Mn
7 Belite Bio 61.40 Bn 61.40 Bn - -32.68 Mn
8 Argenx Se 56.94 Bn 56.94 Bn 1.18 Bn 394.00 Mn
9 Revolution Medicines 37.37 Bn 37.37 Bn - -445.22 Mn
10 NuCana 14.60 Bn 14.60 Bn - -3.72 Mn

Historic Data

Download Data
DateValue
Dec 31, 2025 -3.72 Mn
Sep 30, 2025 -1.05 Mn
Jun 30, 2025 -15.78 Mn
Mar 31, 2025 -3.59 Mn
Dec 31, 2024 -1.11 Mn
Sep 30, 2024 -6.92 Mn
Jun 30, 2024 -10.54 Mn
Mar 31, 2024 -10.49 Mn
Dec 31, 2023 -11.30 Mn
Sep 30, 2023 -10.45 Mn
Jun 30, 2023 -7.85 Mn
Mar 31, 2023 -11.12 Mn
Dec 31, 2022 -20.23 Mn
Sep 30, 2022 -7.29 Mn
Jun 30, 2022 -6.57 Mn
Mar 31, 2022 -14.04 Mn
Dec 31, 2021 -21.21 Mn
Sep 30, 2021 -13.75 Mn
Jun 30, 2021 -14.97 Mn
Mar 31, 2021 -15.84 Mn