Madrigal Pharmaceuticals (MDGL) Operating Income (2010 - 2026)

Madrigal Pharmaceuticals' (MDGL) quarterly Operating Income came in at -$92.7 million in Q1 2026, down 16.91% year-on-year from -$111.6 million in Q1 2025, and down 55.55% on a QoQ basis from -$59.6 million in Q4 2025.

Madrigal Pharmaceuticals (MDGL) Operating Income (2010 - 2026) Analysis & Trends

Madrigal Pharmaceuticals (MDGL) has 17 years of Operating Income data on file, last reported at -$92.7 million in Q1 2026.

  • On a quarterly basis, Operating Income fell 16.91% year-over-year to -$92.7 million in Q1 2026; TTM through Mar 2026 was -$313.5 million, a 26.26% increase from a year earlier, with the FY2025 full-year figure at -$300.1 million, up 39.72% from the prior year.
  • Operating Income for Q1 2026 stood at -$92.7 million, down from -$59.6 million in the prior quarter.
  • Over the last five years, Operating Income for MDGL reached as high as -$47.2 million in Q2 2025 and fell as low as -$162.5 million in Q2 2024.
  • Historically, Operating Income has averaged -$92.0 million across 5 years, with a median of -$85.3 million in 2022.
  • Across the five-year window, Operating Income slumped 94.08% in 2024 and soared 70.96% in 2025, its largest moves.
  • Year by year, Operating Income stood at -$85.3 million in 2022, then tumbled by 37.37% to -$117.2 million in 2023, then surged by 42.82% to -$67.0 million in 2024, then climbed by 11.03% to -$59.6 million in 2025, then tumbled by 55.55% to -$92.7 million in 2026.
  • Per Business Quant data, the three most recent Operating Income figures were -$92.7 million in Q1 2026, -$59.6 million in Q4 2025, and -$114.0 million in Q3 2025.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) Op. Inc (Qtr)
1 Oculis Holding AG 68,785.72 Bn 68,785.72 Bn - -27.75 Mn
2 Nanobiotix 1,895.57 Bn 1,895.51 Bn - -
3 BeOne Medicines 471.35 Bn 466.56 Bn 1.35 Bn 249.90 Mn
4 NuCana 279.75 Bn 279.75 Bn - -3.72 Mn
5 Vertex Pharmaceuticals 120.24 Bn 113.00 Bn 2.59 Bn 1.14 Bn
6 Regeneron Pharmaceuticals 67.80 Bn 59.04 Bn 3.31 Bn 642.90 Mn
7 Belite Bio 62.51 Bn 62.51 Bn - -32.68 Mn
8 Argenx Se 57.38 Bn 57.38 Bn 1.41 Bn 493.00 Mn
9 Revolution Medicines 37.78 Bn 37.78 Bn - -445.22 Mn
10 Madrigal Pharmaceuticals 15.77 Bn 15.54 Bn - -92.72 Mn

Historic Data

Download Data
DateValue
Mar 31, 2026 -92.72 Mn
Dec 31, 2025 -59.61 Mn
Sep 30, 2025 -113.98 Mn
Jun 30, 2025 -47.20 Mn
Mar 31, 2025 -79.31 Mn
Dec 31, 2024 -67.00 Mn
Sep 30, 2024 -116.30 Mn
Jun 30, 2024 -162.54 Mn
Mar 31, 2024 -152.04 Mn
Dec 31, 2023 -117.18 Mn
Sep 30, 2023 -98.53 Mn
Jun 30, 2023 -86.45 Mn
Mar 31, 2023 -78.34 Mn
Dec 31, 2022 -85.30 Mn
Sep 30, 2022 -80.41 Mn
Jun 30, 2022 -70.27 Mn
Mar 31, 2022 -57.59 Mn
Dec 31, 2021 -64.60 Mn
Sep 30, 2021 -63.16 Mn
Jun 30, 2021 -61.74 Mn