Karyopharm Therapeutics KPTI
NASDAQ KPTI
$1.96 +0.14 (+7.69%)
At close: Aug 21, 2026 · 4:00 PM EDT

Karyopharm Therapeutics (KPTI) Interest Expenses (2012 - 2026)

Karyopharm Therapeutics' (KPTI) quarterly Interest Expenses came in at $12.6 million in Q4 2025, up 12.63% YoY from $11.2 million in Q4 2024, and down 77.1% on a QoQ basis from $55.1 million in Q3 2025.

Karyopharm Therapeutics (KPTI) Interest Expenses (2012 - 2026) Analysis & Trends

Karyopharm Therapeutics (KPTI) has 14 years of Interest Expenses data on file, last reported at $12.6 million in Q4 2025.

  • Quarterly Interest Expenses rose 12.63% year-over-year to $12.6 million in Q4 2025, while the trailing twelve-month figure through Dec 2025 was $46.0 million (up 23.04% YoY) and the FY2025 annual result came in at $312.8 million, down 29.97% from the prior year.
  • Interest Expenses fell to $12.6 million in Q4 2025, from $55.1 million in the prior quarter.
  • In the past five years, Interest Expenses ranged from a high of $55.1 million in Q3 2025 to a low of $2.6 million in Q4 2021.
  • A 5-year average of $10.4 million and a median of $6.5 million in 2022 frame the typical range for Interest Expenses.
  • Annual changes were most pronounced in 2022 — Interest Expenses soared 692.93% — and 2023, when it slumped 87.39%.
  • Tracing KPTI's Interest Expenses over 5 years: stood at $2.6 million in 2021, then soared by 692.93% to $20.5 million in 2022, then plunged by 87.39% to $2.6 million in 2023, then jumped by 333.09% to $11.2 million in 2024, then climbed by 12.63% to $12.6 million in 2025.
  • The last three Interest Expenses figures came in at $12.6 million (Q4 2025), $55.1 million (Q3 2025), and $11.2 million (Q2 2025), per Business Quant data.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) Interest Expense (Qtr)
1 Vertex Pharmaceuticals 139.13 Bn 131.28 Bn 2.84 Bn -
2 Regeneron Pharmaceuticals 85.77 Bn 77.77 Bn 3.93 Bn 11.00 Mn
3 Argenx Se 64.64 Bn 59.46 Bn 1.37 Bn -
4 Moderna 58.29 Bn 53.16 Bn 52.00 Mn -
5 BeOne Medicines 41.92 Bn 36.82 Bn 1.53 Bn 39.74 Mn
6 Alnylam Pharmaceuticals 31.58 Bn 28.28 Bn 992.69 Mn 82.05 Mn
7 BioNTech SE 28.12 Bn 9.73 Bn 668.28 Mn -4.89 Mn
8 Insmed 27.39 Bn 26.22 Bn 358.27 Mn 20.27 Mn
9 Royalty Pharma 27.27 Bn 26.43 Bn - 93.62 Mn
10 Karyopharm Therapeutics 56.72 Mn 56.72 Mn 32.35 Mn 13.14 Mn

Historic Data

Download Data
DateValue
Jun 30, 2026 28.58 Mn
Jun 30, 2026 28.58 Mn
Dec 31, 2025 12.62 Mn
Dec 31, 2025 12.62 Mn
Sep 30, 2025 55.11 Mn
Sep 30, 2025 55.11 Mn
Jun 30, 2025 11.23 Mn
Jun 30, 2025 11.23 Mn
Mar 31, 2025 10.99 Mn
Mar 31, 2025 10.99 Mn
Dec 31, 2024 11.20 Mn
Dec 31, 2024 11.20 Mn
Sep 30, 2024 11.39 Mn
Sep 30, 2024 11.39 Mn
Jun 30, 2024 8.95 Mn
Jun 30, 2024 8.95 Mn
Mar 31, 2024 5.88 Mn
Mar 31, 2024 5.88 Mn
Dec 31, 2023 2.59 Mn
Dec 31, 2023 2.59 Mn