Karyopharm Therapeutics (KPTI) Interest Expenses (2012 - 2026)
Karyopharm Therapeutics' (KPTI) quarterly Interest Expenses came in at $12.6 million in Q4 2025, up 12.63% YoY from $11.2 million in Q4 2024, and down 77.1% on a QoQ basis from $55.1 million in Q3 2025.
Karyopharm Therapeutics (KPTI) Interest Expenses (2012 - 2026) Analysis & Trends
Karyopharm Therapeutics (KPTI) has 14 years of Interest Expenses data on file, last reported at $12.6 million in Q4 2025.
- Quarterly Interest Expenses rose 12.63% year-over-year to $12.6 million in Q4 2025, while the trailing twelve-month figure through Dec 2025 was $46.0 million (up 23.04% YoY) and the FY2025 annual result came in at $312.8 million, down 29.97% from the prior year.
- Interest Expenses fell to $12.6 million in Q4 2025, from $55.1 million in the prior quarter.
- In the past five years, Interest Expenses ranged from a high of $55.1 million in Q3 2025 to a low of $2.6 million in Q4 2021.
- A 5-year average of $10.4 million and a median of $6.5 million in 2022 frame the typical range for Interest Expenses.
- Annual changes were most pronounced in 2022 — Interest Expenses soared 692.93% — and 2023, when it slumped 87.39%.
- Tracing KPTI's Interest Expenses over 5 years: stood at $2.6 million in 2021, then soared by 692.93% to $20.5 million in 2022, then plunged by 87.39% to $2.6 million in 2023, then jumped by 333.09% to $11.2 million in 2024, then climbed by 12.63% to $12.6 million in 2025.
- The last three Interest Expenses figures came in at $12.6 million (Q4 2025), $55.1 million (Q3 2025), and $11.2 million (Q2 2025), per Business Quant data.
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Interest Expense (Qtr) |
|---|---|---|---|---|---|
| 1 | Vertex Pharmaceuticals | 139.13 Bn | 131.28 Bn | 2.84 Bn | - |
| 2 | Regeneron Pharmaceuticals | 85.77 Bn | 77.77 Bn | 3.93 Bn | 11.00 Mn |
| 3 | Argenx Se | 64.64 Bn | 59.46 Bn | 1.37 Bn | - |
| 4 | Moderna | 58.29 Bn | 53.16 Bn | 52.00 Mn | - |
| 5 | BeOne Medicines | 41.92 Bn | 36.82 Bn | 1.53 Bn | 39.74 Mn |
| 6 | Alnylam Pharmaceuticals | 31.58 Bn | 28.28 Bn | 992.69 Mn | 82.05 Mn |
| 7 | BioNTech SE | 28.12 Bn | 9.73 Bn | 668.28 Mn | -4.89 Mn |
| 8 | Insmed | 27.39 Bn | 26.22 Bn | 358.27 Mn | 20.27 Mn |
| 9 | Royalty Pharma | 27.27 Bn | 26.43 Bn | - | 93.62 Mn |
| 10 | Karyopharm Therapeutics | 56.72 Mn | 56.72 Mn | 32.35 Mn | 13.14 Mn |
Historic Data
Download Data| Date | Value |
|---|---|
| Jun 30, 2026 | 28.58 Mn |
| Jun 30, 2026 | 28.58 Mn |
| Dec 31, 2025 | 12.62 Mn |
| Dec 31, 2025 | 12.62 Mn |
| Sep 30, 2025 | 55.11 Mn |
| Sep 30, 2025 | 55.11 Mn |
| Jun 30, 2025 | 11.23 Mn |
| Jun 30, 2025 | 11.23 Mn |
| Mar 31, 2025 | 10.99 Mn |
| Mar 31, 2025 | 10.99 Mn |
| Dec 31, 2024 | 11.20 Mn |
| Dec 31, 2024 | 11.20 Mn |
| Sep 30, 2024 | 11.39 Mn |
| Sep 30, 2024 | 11.39 Mn |
| Jun 30, 2024 | 8.95 Mn |
| Jun 30, 2024 | 8.95 Mn |
| Mar 31, 2024 | 5.88 Mn |
| Mar 31, 2024 | 5.88 Mn |
| Dec 31, 2023 | 2.59 Mn |
| Dec 31, 2023 | 2.59 Mn |