Karyopharm Therapeutics (KPTI) Equity Ratio (2012 - 2025)
Karyopharm Therapeutics (KPTI) reported Equity Ratio of 2.7 for Q4 2025, down 138.81% on a YoY basis from 6.96 in Q4 2024, and up 3.44% quarter-over-quarter from 2.8 in Q3 2025.
Karyopharm Therapeutics (KPTI) Equity Ratio (2012 - 2025) Analysis & Trends
Karyopharm Therapeutics has reported Equity Ratio for 14 years, with the latest figure at 2.7 in Q4 2025.
- For the quarter ending Q4 2025, Equity Ratio fell 138.81% year-over-year to 2.7; the trailing twelve-month figure through Dec 2025 stood at 2.7 (down 138.81% YoY), and the FY2025 full-year result was 2.7, down 138.81% from the prior year.
- Equity Ratio for Q4 2025 stood at 2.7, up from 2.8 in the prior quarter.
- The five-year high for Equity Ratio was 0.05 in Q4 2022, with the low at 2.8 in Q3 2025.
- Historically, Equity Ratio has averaged 0.84 across 5 years, with a median of 0.53 in 2021.
- Annual changes were most pronounced in 2022 — Equity Ratio jumped 82.18% — and 2023, when it tumbled 1118.19%.
- Karyopharm Therapeutics' Equity Ratio stood at 0.26 in 2021, then jumped by 82.18% to 0.05 in 2022, then plunged by 1118.19% to 0.57 in 2023, then sank by 99.71% to 1.13 in 2024, then sank by 138.81% to 2.7 in 2025.
- The last three Equity Ratio figures came in at 2.7 (Q4 2025), 2.8 (Q3 2025), and 2.28 (Q2 2025), per Business Quant data.
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Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Equity Ratio (Qtr) |
|---|---|---|---|---|---|
| 1 | Alterity Therapeutics | 762,369.55 Bn | 762,369.51 Bn | - | 191.07 |
| 2 | Belite Bio | 55,096.00 Bn | 55,096.00 Bn | - | 0.98 |
| 3 | Quantum Biopharma | 17,755.80 Bn | 17,755.79 Bn | - | 0.04 |
| 4 | Legend Biotech | 3,486.00 Bn | 3,485.71 Bn | 242.10 Mn | 0.58 |
| 5 | Akari Therapeutics | 1,737.42 Bn | 1,737.41 Bn | - | 0.42 |
| 6 | Evaxion A | 1,551.28 Bn | 1,551.26 Bn | - | - |
| 7 | Psyence Biomedical | 227.32 Bn | 227.31 Bn | - | - |
| 8 | Vertex Pharmaceuticals | 110.84 Bn | 103.59 Bn | 2.59 Bn | 0.73 |
| 9 | Abivax | 91.71 Bn | 91.71 Bn | - | 0.79 |
| 10 | Karyopharm Therapeutics | 95.31 Mn | 31.56 Mn | 32.74 Mn | -2.70 |
Historic Data
Download Data| Date | Value |
|---|---|
| Dec 31, 2025 | -2.70 |
| Sep 30, 2025 | -2.80 |
| Jun 30, 2025 | -2.28 |
| Mar 31, 2025 | -1.61 |
| Dec 31, 2024 | -1.13 |
| Sep 30, 2024 | -0.84 |
| Jun 30, 2024 | -0.62 |
| Mar 31, 2024 | -0.83 |
| Dec 31, 2023 | -0.57 |
| Sep 30, 2023 | -0.37 |
| Jun 30, 2023 | -0.24 |
| Mar 31, 2023 | -0.14 |
| Dec 31, 2022 | -0.05 |
| Sep 30, 2022 | -0.61 |
| Jun 30, 2022 | -0.45 |
| Mar 31, 2022 | -0.28 |
| Dec 31, 2021 | -0.26 |
| Sep 30, 2021 | -0.50 |
| Jun 30, 2021 | -0.29 |
| Mar 31, 2021 | -0.14 |