International Stem Cell (ISCO) Return on Capital Employed [ROCE] (2011 - 2025)
International Stem Cell (ISCO) reported Return on Capital Employed [ROCE] of -56.63% for Q4 2025, down 42.71 percentage points from -13.92% a year earlier and down 69.40 percentage points from the prior quarter.
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Analysis
International Stem Cell (ISCO) Return on Capital Employed [ROCE] (2011 - 2025) Analysis & Trends
For FY2025, International Stem Cell posted Return on Capital Employed [ROCE] of -64.03%, down 52.57 percentage points from FY2024.
- Return on Capital Employed [ROCE] has a five-year change of -0.99 percentage points (FY2020 to FY2025).
- By year, Return on Capital Employed [ROCE] came in at -11.46% in FY2024 (+142.55 pp), -154.01% in FY2023 (-108.88 pp), -45.13% in FY2022 (+185.62 pp) and -230.75% in FY2021 (-167.72 pp).
- The Q4 2025 figure ranks as the lowest quarterly Return on Capital Employed [ROCE] since Q3 2024.
- Year over year, Return on Capital Employed [ROCE] gained in four of the last eight quarters, with an average year-over-year change of +14.74 percentage points.
- The high point for year-over-year Return on Capital Employed [ROCE] in five years was Q1 2023 (a gain of 271.08 percentage points); the low point was Q4 2021 (a drop of 222.90 percentage points).
- Per Business Quant data, the three quarters before Q4 2025 came in at 12.77% (Q3 2025), -13.46% (Q2 2025) and -36.14% (Q1 2025).
Peer Set
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | ROCE (Qtr) |
|---|---|---|---|---|---|
| 1 | Eli Lilly | 1,082.65 Bn | 1,051.23 Bn | 19.71 Bn | 46.74% |
| 2 | Johnson & Johnson | 623.68 Bn | 542.21 Bn | 17.26 Bn | 17.83% |
| 3 | AbbVie | 459.43 Bn | 432.59 Bn | 12.70 Bn | 17.92% |
| 4 | Merck | 354.80 Bn | 309.23 Bn | 12.21 Bn | 6.28% |
| 5 | Novartis Ag | 269.16 Bn | 225.03 Bn | 11.24 Bn | 19.32% |
| 6 | Astrazeneca | 244.40 Bn | 217.97 Bn | 12.86 Bn | 9.54% |
| 7 | Amgen | 220.17 Bn | 175.57 Bn | 7.24 Bn | 16.66% |
| 8 | Gilead Sciences | 183.05 Bn | 157.16 Bn | 6.22 Bn | -5.97% |
| 9 | Pfizer | 160.27 Bn | 107.22 Bn | 10.94 Bn | 11.86% |
| 10 | International Stem Cell | 2.40 Mn | -1.57 Mn | 1.46 Mn | - |
Historic Data
Download Data
Historic Data
| Date | Value |
|---|---|
| Dec 31, 2025 | -56.63% |
| Sep 30, 2025 | 12.77% |
| Jun 30, 2025 | -13.46% |
| Mar 31, 2025 | -36.14% |
| Dec 31, 2024 | -13.92% |
| Sep 30, 2024 | -81.17% |
| Jun 30, 2024 | -120.22% |
| Mar 31, 2024 | -203.87% |
| Dec 31, 2023 | -97.00% |
| Sep 30, 2023 | -17.26% |
| Jun 30, 2023 | -46.49% |
| Mar 31, 2023 | -50.61% |
| Dec 31, 2022 | -40.35% |
| Sep 30, 2022 | -92.05% |
| Jun 30, 2022 | -116.42% |
| Mar 31, 2022 | -321.70% |
| Dec 31, 2021 | -291.86% |
| Sep 30, 2021 | -251.78% |
| Jun 30, 2021 | -180.92% |
| Mar 31, 2021 | -314.38% |
API Access
International Stem Cell Return on Capital Employed [ROCE] API
Pull this series into your own models, spreadsheets and apps with the Business Quant
Historical Metrics API. The request below matches the chart above — change the
frequency, period or values and it follows. Swap YOUR_API_KEY for your own key.
https://data.businessquant.com/historic?slug=return-on-capital-employed-%5Broce%5D&ticker=ISCO&period=max&api_key=YOUR_API_KEYimport requests
url = "https://data.businessquant.com/historic"
params = {"slug": "return-on-capital-employed-[roce]", "ticker": "ISCO", "period": "max", "api_key": "YOUR_API_KEY"}
data = requests.get(url, params=params).json()const res = await fetch("https://data.businessquant.com/historic?slug=return-on-capital-employed-%5Broce%5D&ticker=ISCO&period=max&api_key=YOUR_API_KEY");
const data = await res.json();