Ionis Pharmaceuticals (IONS) Return on Sales [ROS] (2009 - 2026)
Ionis Pharmaceuticals (IONS) recorded Return on Sales [ROS] of -38.18% in Q2 2026, down 69.11 percentage points from 30.93% a year earlier but up 9.54 percentage points from the prior quarter.
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Analysis
Ionis Pharmaceuticals (IONS) Return on Sales [ROS] (2009 - 2026) Analysis & Trends
On a TTM basis, Ionis Pharmaceuticals' Return on Sales [ROS] came in at -68.00% as of Jun 30, 2026, down 39.77 percentage points year-over-year; for FY2025, it was -40.45%, up 26.93 percentage points from FY2024.
- Annual Return on Sales [ROS] has a five-year change of -16.85 percentage points (FY2020 to FY2025).
- Across earlier years, Return on Sales [ROS] came in at -67.37% in FY2024 (-22.46 pp), -44.91% in FY2023 (+24.93 pp), -69.84% in FY2022 (-66.11 pp) and -3.72% in FY2021 (+19.87 pp).
- Quarterly Return on Sales [ROS] has ranged from -136.95% in Q4 2022 to 50.14% in Q4 2021 over the past five years.
- On a year-over-year basis, Return on Sales [ROS] rose in four of the last eight quarters, with an average year-over-year change of -4.74 percentage points.
- Peak year-over-year performance for Return on Sales [ROS] in the last five years was a gain of 135.07 percentage points in Q4 2023, against a drop of 187.09 percentage points in Q4 2022 at the low end.
- Per Business Quant, the preceding three quarters came in at -47.72% (Q1 2026), -105.47% (Q4 2025) and -102.21% (Q3 2025).
Peer Set
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | ROS (Qtr) |
|---|---|---|---|---|---|
| 1 | Eli Lilly | 1,076.25 Bn | 1,044.84 Bn | 19.71 Bn | 51.16% |
| 2 | Johnson & Johnson | 617.18 Bn | 535.70 Bn | 17.26 Bn | 28.21% |
| 3 | AbbVie | 464.58 Bn | 437.73 Bn | 12.70 Bn | 37.86% |
| 4 | Merck | 356.04 Bn | 310.47 Bn | 12.21 Bn | -3.52% |
| 5 | Novartis Ag | 269.07 Bn | 224.94 Bn | 11.24 Bn | 32.97% |
| 6 | Astrazeneca | 243.21 Bn | 216.77 Bn | 12.86 Bn | 20.57% |
| 7 | Amgen | 217.88 Bn | 173.28 Bn | 7.24 Bn | 34.95% |
| 8 | Gilead Sciences | 179.62 Bn | 153.74 Bn | 6.22 Bn | -133.21% |
| 9 | Pfizer | 158.45 Bn | 105.40 Bn | 10.94 Bn | 28.37% |
| 10 | Ionis Pharmaceuticals | 7.21 Bn | -1.68 Bn | 265.21 Mn | -38.18% |
Historic Data
Download Data
Historic Data
| Date | Value |
|---|---|
| Jun 30, 2026 | -38.18% |
| Mar 31, 2026 | -47.72% |
| Dec 31, 2025 | -105.47% |
| Sep 30, 2025 | -102.21% |
| Jun 30, 2025 | 30.93% |
| Mar 31, 2025 | -111.59% |
| Dec 31, 2024 | -48.91% |
| Sep 30, 2024 | -111.09% |
| Jun 30, 2024 | -29.34% |
| Mar 31, 2024 | -125.12% |
| Dec 31, 2023 | -1.89% |
| Sep 30, 2023 | -99.35% |
| Jun 30, 2023 | -47.87% |
| Mar 31, 2023 | -87.45% |
| Dec 31, 2022 | -136.95% |
| Sep 30, 2022 | -37.03% |
| Jun 30, 2022 | -63.92% |
| Mar 31, 2022 | -40.52% |
| Dec 31, 2021 | 50.14% |
| Sep 30, 2021 | -64.50% |
API Access
Ionis Pharmaceuticals Return on Sales [ROS] API
Pull this series into your own models, spreadsheets and apps with the Business Quant
Historical Metrics API. The request below matches the chart above — change the
frequency, period or values and it follows. Swap YOUR_API_KEY for your own key.
https://data.businessquant.com/historic?slug=return-on-sales-%5Bros%5D&ticker=IONS&period=max&api_key=YOUR_API_KEYimport requests
url = "https://data.businessquant.com/historic"
params = {"slug": "return-on-sales-[ros]", "ticker": "IONS", "period": "max", "api_key": "YOUR_API_KEY"}
data = requests.get(url, params=params).json()const res = await fetch("https://data.businessquant.com/historic?slug=return-on-sales-%5Bros%5D&ticker=IONS&period=max&api_key=YOUR_API_KEY");
const data = await res.json();