Ionis Pharmaceuticals (IONS) Return on Equity [ROE] (2010 - 2026)
Ionis Pharmaceuticals (IONS) reported Return on Equity [ROE] of -121.39% for Q2 2026, down 72.95 percentage points from -48.44% a year earlier and down 54.70 percentage points from the prior quarter.
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Analysis
Ionis Pharmaceuticals (IONS) Return on Equity [ROE] (2010 - 2026) Analysis & Trends
For FY2025, Ionis Pharmaceuticals posted Return on Equity [ROE] of -70.80%, up 22.31 percentage points from FY2024.
- Return on Equity [ROE] has a five-year change of -29.45 percentage points (FY2020 to FY2025).
- By year, Return on Equity [ROE] came in at -93.10% in FY2024 (-16.76 pp), -76.34% in FY2023 (-36.22 pp), -40.12% in FY2022 (-36.34 pp) and -3.78% in FY2021 (+37.57 pp).
- The Q2 2026 figure ranks as the lowest quarterly Return on Equity [ROE] since Q2 2024.
- Year over year, Return on Equity [ROE] gained in seven of the last eight quarters, with an average year-over-year change of +19.96 percentage points.
- The high point for year-over-year Return on Equity [ROE] in five years was Q3 2022 (a gain of 110.59 percentage points); the low point was Q3 2021 (a drop of 114.68 percentage points).
- Per Business Quant data, the three quarters before Q2 2026 came in at -66.70% (Q1 2026), -68.90% (Q4 2025) and -41.03% (Q3 2025).
Peer Set
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | ROE (Qtr) |
|---|---|---|---|---|---|
| 1 | Johnson & Johnson | 638.12 Bn | 556.64 Bn | 17.26 Bn | 25.32% |
| 2 | AbbVie | 462.60 Bn | 435.75 Bn | 12.70 Bn | - |
| 3 | Merck | 358.70 Bn | 313.13 Bn | 12.21 Bn | 7.21% |
| 4 | Novartis Ag | 272.16 Bn | 228.03 Bn | 11.24 Bn | 84.40% |
| 5 | Astrazeneca | 250.36 Bn | 223.92 Bn | 12.86 Bn | 21.39% |
| 6 | Amgen | 227.87 Bn | 183.27 Bn | 7.24 Bn | 83.75% |
| 7 | Gilead Sciences | 184.97 Bn | 159.08 Bn | 6.22 Bn | -18.38% |
| 8 | Pfizer | 162.61 Bn | 109.56 Bn | 10.94 Bn | 4.97% |
| 9 | Vertex Pharmaceuticals | 132.45 Bn | 104.46 Bn | 2.84 Bn | 22.24% |
| 10 | Ionis Pharmaceuticals | 7.40 Bn | -1.50 Bn | 265.21 Mn | -121.39% |
Historic Data
Download Data
Historic Data
| Date | Value |
|---|---|
| Jun 30, 2026 | -121.39% |
| Mar 31, 2026 | -66.70% |
| Dec 31, 2025 | -68.90% |
| Sep 30, 2025 | -41.03% |
| Jun 30, 2025 | -48.44% |
| Mar 31, 2025 | -86.09% |
| Dec 31, 2024 | -72.58% |
| Sep 30, 2024 | -77.49% |
| Jun 30, 2024 | -130.58% |
| Mar 31, 2024 | -112.64% |
| Dec 31, 2023 | -104.34% |
| Sep 30, 2023 | -110.11% |
| Jun 30, 2023 | -67.57% |
| Mar 31, 2023 | -62.10% |
| Dec 31, 2022 | -46.23% |
| Sep 30, 2022 | 1.19% |
| Jun 30, 2022 | -4.23% |
| Mar 31, 2022 | -0.53% |
| Dec 31, 2021 | -4.39% |
| Sep 30, 2021 | -109.39% |
API Access
Ionis Pharmaceuticals Return on Equity [ROE] API
Pull this series into your own models, spreadsheets and apps with the Business Quant
Historical Metrics API. The request below matches the chart above — change the
frequency, period or values and it follows. Swap YOUR_API_KEY for your own key.
https://data.businessquant.com/historic?slug=return-on-equity-%5Broe%5D&ticker=IONS&period=max&api_key=YOUR_API_KEYimport requests
url = "https://data.businessquant.com/historic"
params = {"slug": "return-on-equity-[roe]", "ticker": "IONS", "period": "max", "api_key": "YOUR_API_KEY"}
data = requests.get(url, params=params).json()const res = await fetch("https://data.businessquant.com/historic?slug=return-on-equity-%5Broe%5D&ticker=IONS&period=max&api_key=YOUR_API_KEY");
const data = await res.json();