Growth Metrics

Ionis Pharmaceuticals (IONS) Profit After Tax (2016 - 2025)

Ionis Pharmaceuticals (IONS) has 17 years of Profit After Tax data on record, last reported at -$229.4 million in Q4 2025.

  • For Q4 2025, Profit After Tax fell 119.83% year-over-year to -$229.4 million; the TTM value through Dec 2025 reached -$381.4 million, up 15.98%, while the annual FY2025 figure was -$381.4 million, 15.97% up from the prior year.
  • Profit After Tax reached -$229.4 million in Q4 2025 per IONS's latest filing, down from -$128.6 million in the prior quarter.
  • Across five years, Profit After Tax topped out at $224.6 million in Q4 2021 and bottomed at -$229.4 million in Q4 2025.
  • Average Profit After Tax over 5 years is -$75.0 million, with a median of -$87.6 million recorded in 2021.
  • Peak YoY movement for Profit After Tax: tumbled 1026.51% in 2024, then skyrocketed 286.45% in 2025.
  • A 5-year view of Profit After Tax shows it stood at $224.6 million in 2021, then tumbled by 123.34% to -$52.4 million in 2022, then skyrocketed by 82.33% to -$9.3 million in 2023, then crashed by 1026.51% to -$104.3 million in 2024, then tumbled by 119.83% to -$229.4 million in 2025.
  • Per Business Quant database, its latest 3 readings for Profit After Tax were -$229.4 million in Q4 2025, -$128.6 million in Q3 2025, and $123.6 million in Q2 2025.