Ionis Pharmaceuticals (IONS) EBT (2009 - 2026)

Ionis Pharmaceuticals' (IONS) quarterly EBT came in at -$92.3 million in Q1 2026, up 37.13% year-on-year from -$67.3 million in Q1 2025, and up 59.5% quarter-over-quarter from -$227.9 million in Q4 2025.

Ionis Pharmaceuticals (IONS) EBT (2009 - 2026) Analysis & Trends

Ionis Pharmaceuticals' EBT history runs 18 years deep, the most recent figure standing at -$92.3 million for Q1 2026.

  • On a quarterly basis, EBT rose 37.13% year-over-year to -$92.3 million in Q1 2026; TTM through Mar 2026 was -$325.1 million, a 30.06% increase from a year earlier, with the FY2025 full-year figure at -$379.6 million, up 17.61% from the prior year.
  • EBT climbed to -$92.3 million in Q1 2026 per IONS's latest filing, from -$227.9 million in the prior quarter.
  • Across five years, EBT topped out at $331.9 million in Q4 2023 and bottomed at -$227.9 million in Q4 2025.
  • The 5-year median for EBT is -$102.9 million (2022), against an average of -$70.0 million.
  • Biggest YoY gain for EBT was 848.79% in 2023; the steepest drop was 201.46% in 2023.
  • Year by year, EBT stood at -$44.3 million in 2022, then soared by 848.79% to $331.9 million in 2023, then plunged by 132.44% to -$107.7 million in 2024, then slumped by 111.65% to -$227.9 million in 2025, then surged by 59.5% to -$92.3 million in 2026.
  • Per Business Quant, the three latest IONS EBT figures stand at -$92.3 million (Q1 2026), -$227.9 million (Q4 2025), and -$128.4 million (Q3 2025).

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) EBT (Qtr)
1 Oculis Holding AG 67,072.09 Bn 67,072.09 Bn - -36.97 Mn
2 Nanobiotix 1,894.61 Bn 1,894.55 Bn - -
3 Akari Therapeutics 1,014.18 Bn 1,014.18 Bn - -15.31 Mn
4 BeOne Medicines 471.64 Bn 466.85 Bn 1.35 Bn 259.22 Mn
5 Vertex Pharmaceuticals 121.72 Bn 114.47 Bn 2.59 Bn 1.25 Bn
6 Regeneron Pharmaceuticals 68.28 Bn 59.52 Bn 3.31 Bn 831.20 Mn
7 Belite Bio 61.40 Bn 61.40 Bn - -26.94 Mn
8 Argenx Se 56.94 Bn 56.94 Bn 1.18 Bn 438.00 Mn
9 Revolution Medicines 37.37 Bn 37.37 Bn - -453.82 Mn
10 Ionis Pharmaceuticals 9.35 Bn 7.43 Bn 243.11 Mn -92.31 Mn

Historic Data

Download Data
DateValue
Mar 31, 2026 -92.31 Mn
Dec 31, 2025 -227.92 Mn
Sep 30, 2025 -128.39 Mn
Jun 30, 2025 123.53 Mn
Mar 31, 2025 -146.82 Mn
Dec 31, 2024 -107.68 Mn
Sep 30, 2024 -144.10 Mn
Jun 30, 2024 -66.20 Mn
Mar 31, 2024 -142.73 Mn
Dec 31, 2023 331.94 Mn
Sep 30, 2023 -140.81 Mn
Jun 30, 2023 -77.45 Mn
Mar 31, 2023 -112.94 Mn
Dec 31, 2022 -44.33 Mn
Sep 30, 2022 -46.71 Mn
Jun 30, 2022 -102.88 Mn
Mar 31, 2022 -64.07 Mn
Dec 31, 2021 254.88 Mn
Sep 30, 2021 -83.77 Mn
Jun 30, 2021 -80.55 Mn