Ionis Pharmaceuticals (IONS) EBT (2009 - 2026)

Ionis Pharmaceuticals (IONS) recorded quarterly EBT of -$92.3 million in Q1 2026, up 59.78% quarter-over-quarter from -$229.5 million in Q4 2025, and up 37.13% on a YoY basis from -$67.3 million in Q1 2025.

Ionis Pharmaceuticals (IONS) EBT (2009 - 2026) Analysis & Trends

Ionis Pharmaceuticals' EBT history runs 18 years deep, the most recent figure standing at -$92.3 million for Q1 2026.

  • In Q1 2026, EBT rose 37.13% year-over-year to -$92.3 million; the TTM figure through Mar 2026 stood at -$326.7 million (up 29.72% YoY), while the FY2025 annual figure was -$381.2 million, up 17.26% from the prior year.
  • EBT was -$92.3 million for Q1 2026 at Ionis Pharmaceuticals, up from -$229.5 million in the prior quarter.
  • In the past five years, EBT ranged from a high of $123.5 million in Q2 2025 to a low of -$229.5 million in Q4 2025.
  • Historically, EBT has averaged -$89.8 million across 5 years, with a median of -$102.9 million in 2022.
  • The sharpest annual moves came in 2024 and 2025: EBT sank 3791.69% in 2024, then jumped 286.6% in 2025.
  • A 5-year view of EBT shows it stood at -$44.8 million in 2022, then surged by 93.83% to -$2.8 million in 2023, then tumbled by 3791.69% to -$107.7 million in 2024, then slumped by 113.12% to -$229.5 million in 2025, then soared by 59.78% to -$92.3 million in 2026.
  • The last three EBT figures came in at -$92.3 million (Q1 2026), -$229.5 million (Q4 2025), and -$128.4 million (Q3 2025), per Business Quant data.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) EBT (Qtr)
1 Alterity Therapeutics 925,601.88 Bn 925,601.85 Bn - -
2 Belite Bio 58,560.00 Bn 58,560.00 Bn - -26.94 Mn
3 Quantum Biopharma 17,284.41 Bn 17,284.40 Bn - -2.97 Mn
4 Legend Biotech 2,809.00 Bn 2,808.71 Bn 242.10 Mn 19.60 Mn
5 Evaxion A 1,334.43 Bn 1,334.42 Bn - -3.18 Mn
6 Akari Therapeutics 1,312.27 Bn 1,312.26 Bn - -15.31 Mn
7 Psyence Biomedical 212.16 Bn 212.16 Bn - -1.50 Mn
8 Vertex Pharmaceuticals 114.83 Bn 107.58 Bn 2.59 Bn 1.25 Bn
9 Abivax 91.96 Bn 91.96 Bn - -56.48 Mn
10 Ionis Pharmaceuticals 12.23 Bn 10.31 Bn 243.11 Mn -92.31 Mn

Historic Data

Download Data
DateValue
Mar 31, 2026 -92.31 Mn
Dec 31, 2025 -229.50 Mn
Sep 30, 2025 -128.39 Mn
Jun 30, 2025 123.53 Mn
Mar 31, 2025 -146.82 Mn
Dec 31, 2024 -107.68 Mn
Sep 30, 2024 -144.10 Mn
Jun 30, 2024 -66.20 Mn
Mar 31, 2024 -142.73 Mn
Dec 31, 2023 -2.77 Mn
Sep 30, 2023 -140.81 Mn
Jun 30, 2023 -77.45 Mn
Mar 31, 2023 -112.94 Mn
Dec 31, 2022 -44.84 Mn
Sep 30, 2022 -46.71 Mn
Jun 30, 2022 -102.88 Mn
Mar 31, 2022 -64.07 Mn
Dec 31, 2021 224.10 Mn
Sep 30, 2021 -83.77 Mn
Jun 30, 2021 -80.55 Mn