Ionis Pharmaceuticals (IONS) EBITDA (2009 - 2026)
Ionis Pharmaceuticals (IONS) recorded quarterly EBITDA of -$117.4 million in Q1 2026, up 45.25% quarter-over-quarter from -$214.5 million in Q4 2025, and up 20.04% on a YoY basis from -$97.8 million in Q1 2025.
Ionis Pharmaceuticals (IONS) EBITDA (2009 - 2026) Analysis & Trends
Ionis Pharmaceuticals' EBITDA history runs 18 years deep, the most recent figure standing at -$117.4 million for Q1 2026.
- In Q1 2026, EBITDA rose 20.04% year-over-year to -$117.4 million; the TTM figure through Mar 2026 stood at -$352.2 million (up 25.44% YoY), while the FY2025 annual figure was -$79.7 million, up 17.49% from the prior year.
- EBITDA was -$117.4 million for Q1 2026 at Ionis Pharmaceuticals, up from -$214.5 million in the prior quarter.
- In the past five years, EBITDA ranged from a high of $139.8 million in Q2 2025 to a low of -$214.5 million in Q4 2025.
- Historically, EBITDA has averaged -$102.2 million across 5 years, with a median of -$114.1 million in 2023.
- The sharpest annual moves came in 2024 and 2025: EBITDA plunged 1710.21% in 2024, then soared 311.55% in 2025.
- A 5-year view of EBITDA shows it stood at -$208.0 million in 2022, then jumped by 97.06% to -$6.1 million in 2023, then slumped by 1710.21% to -$110.8 million in 2024, then slumped by 93.52% to -$214.5 million in 2025, then surged by 45.25% to -$117.4 million in 2026.
- The last three EBITDA figures came in at -$117.4 million (Q1 2026), -$214.5 million (Q4 2025), and -$160.2 million (Q3 2025), per Business Quant data.
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Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | EBITDA (Qtr) |
|---|---|---|---|---|---|
| 1 | Alterity Therapeutics | 925,601.88 Bn | 925,601.85 Bn | - | - |
| 2 | Belite Bio | 58,560.00 Bn | 58,560.00 Bn | - | -26.92 Mn |
| 3 | Quantum Biopharma | 17,284.41 Bn | 17,284.40 Bn | - | -13.63 Mn |
| 4 | Legend Biotech | 2,809.00 Bn | 2,808.71 Bn | 242.10 Mn | -19.70 Mn |
| 5 | Evaxion A | 1,334.43 Bn | 1,334.42 Bn | - | -3.82 Mn |
| 6 | Akari Therapeutics | 1,312.27 Bn | 1,312.26 Bn | - | -14.44 Mn |
| 7 | Psyence Biomedical | 212.16 Bn | 212.16 Bn | - | -752,618.00 |
| 8 | Vertex Pharmaceuticals | 114.83 Bn | 107.58 Bn | 2.59 Bn | 1.14 Bn |
| 9 | Abivax | 91.96 Bn | 91.96 Bn | - | -65.83 Mn |
| 10 | Ionis Pharmaceuticals | 12.23 Bn | 10.31 Bn | 243.11 Mn | -117.42 Mn |
Historic Data
Download Data| Date | Value |
|---|---|
| Mar 31, 2026 | -117.42 Mn |
| Dec 31, 2025 | -214.46 Mn |
| Sep 30, 2025 | -160.18 Mn |
| Jun 30, 2025 | 139.82 Mn |
| Mar 31, 2025 | -146.86 Mn |
| Dec 31, 2024 | -110.82 Mn |
| Sep 30, 2024 | -148.66 Mn |
| Jun 30, 2024 | -66.09 Mn |
| Mar 31, 2024 | -149.51 Mn |
| Dec 31, 2023 | -6.12 Mn |
| Sep 30, 2023 | -143.27 Mn |
| Jun 30, 2023 | -90.20 Mn |
| Mar 31, 2023 | -114.15 Mn |
| Dec 31, 2022 | -208.02 Mn |
| Sep 30, 2022 | -59.15 Mn |
| Jun 30, 2022 | -85.51 Mn |
| Mar 31, 2022 | -57.50 Mn |
| Dec 31, 2021 | 220.60 Mn |
| Sep 30, 2021 | -85.85 Mn |
| Jun 30, 2021 | -72.97 Mn |