Ionis Pharmaceuticals IONS
NASDAQ IONS
$58.09 -0.04 (-0.07%)
As of: Sep 4, 2026 · 3:59 PM EDT

Ionis Pharmaceuticals (IONS) EBIT (2009 - 2026)

Ionis Pharmaceuticals (IONS) posted quarterly EBIT of -$102.3 million for Q2 2026, down 173.16% year-over-year from $139.8 million in Q2 2025, and up 12.89% quarter-over-quarter from -$117.4 million in Q1 2026.

Analysis

Ionis Pharmaceuticals (IONS) EBIT (2009 - 2026) Analysis & Trends

Ionis Pharmaceuticals' EBIT history runs 18 years deep, the most recent figure standing at -$102.3 million for Q2 2026.

  • In Q2 2026, EBIT fell 173.16% year-over-year to -$102.3 million; the TTM figure through Jun 2026 stood at -$594.4 million (down 123.01% YoY), while the FY2025 annual figure was -$381.7 million, up 19.66% from the prior year.
  • EBIT for Q2 2026 stood at -$102.3 million, up from -$117.4 million in the prior quarter.
  • The five-year high for EBIT was $139.8 million in Q2 2025, with the low at -$214.5 million in Q4 2025.
  • The 5-year median for EBIT is -$112.5 million (2023), against an average of -$102.2 million.
  • The sharpest annual moves came in 2024 and 2025: EBIT tumbled 1710.21% in 2024, then surged 311.55% in 2025.
  • Ionis Pharmaceuticals' EBIT stood at -$208.0 million in 2022, then soared by 97.06% to -$6.1 million in 2023, then sank by 1710.21% to -$110.8 million in 2024, then sank by 93.52% to -$214.5 million in 2025, then soared by 52.3% to -$102.3 million in 2026.
  • Business Quant data shows IONS's EBIT at -$102.3 million in Q2 2026, -$117.4 million in Q1 2026, and -$214.5 million in Q4 2025.
Peer Set

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) EBIT (Qtr)
1 Vertex Pharmaceuticals 138.47 Bn 130.62 Bn 2.84 Bn 1.25 Bn
2 Regeneron Pharmaceuticals 85.18 Bn 77.19 Bn 3.93 Bn 1.29 Bn
3 Argenx Se 63.38 Bn 58.19 Bn 1.37 Bn 493.00 Mn
4 Moderna 58.09 Bn 52.95 Bn 52.00 Mn -815.00 Mn
5 Revolution Medicines 44.33 Bn 44.33 Bn - -505.13 Mn
6 BeOne Medicines 40.02 Bn 34.92 Bn 1.53 Bn 325.05 Mn
7 Alnylam Pharmaceuticals 35.57 Bn 32.27 Bn 992.69 Mn 231.44 Mn
8 Royalty Pharma 28.45 Bn 27.61 Bn - 133.12 Mn
9 Insmed 27.48 Bn 26.32 Bn 358.27 Mn -1.55 Mn
10 Ionis Pharmaceuticals 9.60 Bn 7.55 Bn 265.21 Mn -102.29 Mn
Historic Data

Historic Data

Download Data
DateValue
Jun 30, 2026 -102.29 Mn
Mar 31, 2026 -117.42 Mn
Dec 31, 2025 -214.46 Mn
Sep 30, 2025 -160.18 Mn
Jun 30, 2025 139.82 Mn
Mar 31, 2025 -146.86 Mn
Dec 31, 2024 -110.82 Mn
Sep 30, 2024 -148.66 Mn
Jun 30, 2024 -66.09 Mn
Mar 31, 2024 -149.51 Mn
Dec 31, 2023 -6.12 Mn
Sep 30, 2023 -143.27 Mn
Jun 30, 2023 -90.20 Mn
Mar 31, 2023 -114.15 Mn
Dec 31, 2022 -208.02 Mn
Sep 30, 2022 -59.15 Mn
Jun 30, 2022 -85.51 Mn
Mar 31, 2022 -57.50 Mn
Dec 31, 2021 220.60 Mn
Sep 30, 2021 -85.85 Mn