Ionis Pharmaceuticals (IONS) EBIT (2009 - 2026)
Ionis Pharmaceuticals' (IONS) quarterly EBIT came in at -$117.4 million in Q1 2026, up 20.04% year-on-year from -$97.8 million in Q1 2025, and up 45.25% quarter-over-quarter from -$214.5 million in Q4 2025.
Ionis Pharmaceuticals (IONS) EBIT (2009 - 2026) Analysis & Trends
Ionis Pharmaceuticals' EBIT history runs 18 years deep, the most recent figure standing at -$117.4 million for Q1 2026.
- On a quarterly basis, EBIT rose 20.04% year-over-year to -$117.4 million in Q1 2026; TTM through Mar 2026 was -$352.2 million, a 25.44% increase from a year earlier, with the FY2025 full-year figure at -$381.7 million, up 19.66% from the prior year.
- EBIT grew to -$117.4 million in Q1 2026 per IONS's latest filing, from -$214.5 million in the prior quarter.
- Across five years, EBIT topped out at $139.8 million in Q2 2025 and bottomed at -$214.5 million in Q4 2025.
- The 5-year median for EBIT is -$114.1 million (2023), against an average of -$102.2 million.
- Across the five-year window, EBIT plunged 1710.21% in 2024 and surged 311.55% in 2025, its largest moves.
- Year by year, EBIT stood at -$208.0 million in 2022, then jumped by 97.06% to -$6.1 million in 2023, then plunged by 1710.21% to -$110.8 million in 2024, then plunged by 93.52% to -$214.5 million in 2025, then surged by 45.25% to -$117.4 million in 2026.
- Per Business Quant, the three latest IONS EBIT figures stand at -$117.4 million (Q1 2026), -$214.5 million (Q4 2025), and -$160.2 million (Q3 2025).
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Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | EBIT (Qtr) |
|---|---|---|---|---|---|
| 1 | Oculis Holding AG | 67,072.09 Bn | 67,072.09 Bn | - | -27.75 Mn |
| 2 | Nanobiotix | 1,894.61 Bn | 1,894.55 Bn | - | - |
| 3 | Akari Therapeutics | 1,014.18 Bn | 1,014.18 Bn | - | -15.76 Mn |
| 4 | BeOne Medicines | 471.64 Bn | 466.85 Bn | 1.35 Bn | 249.90 Mn |
| 5 | Vertex Pharmaceuticals | 121.72 Bn | 114.47 Bn | 2.59 Bn | 1.14 Bn |
| 6 | Regeneron Pharmaceuticals | 68.28 Bn | 59.52 Bn | 3.31 Bn | 642.90 Mn |
| 7 | Belite Bio | 61.40 Bn | 61.40 Bn | - | -32.68 Mn |
| 8 | Argenx Se | 56.94 Bn | 56.94 Bn | 1.18 Bn | 394.00 Mn |
| 9 | Revolution Medicines | 37.37 Bn | 37.37 Bn | - | -445.22 Mn |
| 10 | Ionis Pharmaceuticals | 9.35 Bn | 7.43 Bn | 243.11 Mn | -117.42 Mn |
Historic Data
Download Data| Date | Value |
|---|---|
| Mar 31, 2026 | -117.42 Mn |
| Dec 31, 2025 | -214.46 Mn |
| Sep 30, 2025 | -160.18 Mn |
| Jun 30, 2025 | 139.82 Mn |
| Mar 31, 2025 | -146.86 Mn |
| Dec 31, 2024 | -110.82 Mn |
| Sep 30, 2024 | -148.66 Mn |
| Jun 30, 2024 | -66.09 Mn |
| Mar 31, 2024 | -149.51 Mn |
| Dec 31, 2023 | -6.12 Mn |
| Sep 30, 2023 | -143.27 Mn |
| Jun 30, 2023 | -90.20 Mn |
| Mar 31, 2023 | -114.15 Mn |
| Dec 31, 2022 | -208.02 Mn |
| Sep 30, 2022 | -59.15 Mn |
| Jun 30, 2022 | -85.51 Mn |
| Mar 31, 2022 | -57.50 Mn |
| Dec 31, 2021 | 220.60 Mn |
| Sep 30, 2021 | -85.85 Mn |
| Jun 30, 2021 | -72.97 Mn |