Cue Biopharma (CUE) EBITDA (2017 - 2025)

Cue Biopharma's (CUE) quarterly EBITDA came in at $23.0 million in Q4 2025, up 342.72% year-on-year from $5.2 million in Q4 2024, and up 409.51% quarter-over-quarter from -$7.4 million in Q3 2025.

Cue Biopharma (CUE) EBITDA (2017 - 2025) Analysis & Trends

Cue Biopharma has disclosed EBITDA across 9 years of filings, most recently posting $23.0 million for Q4 2025.

  • EBITDA for Q4 2025 came in at $23.0 million, up 342.72% year-over-year; the trailing twelve-month figure through Dec 2025 was -$5.1 million (up 87.37% YoY), and the FY2025 annual result was -$5.5 million, up 86.52% from the prior year.
  • EBITDA came in at $23.0 million for Q4 2025 at Cue Biopharma, up from -$7.4 million in the prior quarter.
  • In the past five years, EBITDA ranged from a high of $23.0 million in Q4 2025 to a low of -$14.6 million in Q4 2022.
  • The 5-year median for EBITDA is -$11.7 million (2022), against an average of -$9.7 million.
  • Across the five-year window, EBITDA slumped 74.09% in 2022 and jumped 342.72% in 2025, its largest moves.
  • Cue Biopharma's EBITDA stood at -$8.4 million in 2021, then slumped by 74.09% to -$14.6 million in 2022, then advanced by 7.96% to -$13.4 million in 2023, then advanced by 29.31% to -$9.5 million in 2024, then soared by 342.72% to $23.0 million in 2025.
  • The last three EBITDA figures came in at $23.0 million (Q4 2025), -$7.4 million (Q3 2025), and -$8.5 million (Q2 2025), per Business Quant data.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) EBITDA (Qtr)
1 Alterity Therapeutics 925,601.88 Bn 925,601.85 Bn - -
2 Belite Bio 58,560.00 Bn 58,560.00 Bn - -26.92 Mn
3 Quantum Biopharma 17,284.41 Bn 17,284.40 Bn - -13.63 Mn
4 Legend Biotech 2,809.00 Bn 2,808.71 Bn 242.10 Mn -19.70 Mn
5 Evaxion A 1,334.43 Bn 1,334.42 Bn - -3.82 Mn
6 Akari Therapeutics 1,312.27 Bn 1,312.26 Bn - -14.44 Mn
7 Psyence Biomedical 212.16 Bn 212.16 Bn - -752,618.00
8 Vertex Pharmaceuticals 114.83 Bn 107.58 Bn 2.59 Bn 1.14 Bn
9 Abivax 91.96 Bn 91.96 Bn - -65.83 Mn
10 Cue Biopharma 581.16 Mn 553.47 Mn - 23.05 Mn

Historic Data

Download Data
DateValue
Dec 31, 2025 23.05 Mn
Sep 30, 2025 -7.45 Mn
Jun 30, 2025 -8.48 Mn
Mar 31, 2025 -12.26 Mn
Dec 31, 2024 -9.50 Mn
Sep 30, 2024 -8.66 Mn
Jun 30, 2024 -10.17 Mn
Mar 31, 2024 -12.35 Mn
Dec 31, 2023 -13.43 Mn
Sep 30, 2023 -11.00 Mn
Jun 30, 2023 -13.15 Mn
Mar 31, 2023 -13.05 Mn
Dec 31, 2022 -14.60 Mn
Sep 30, 2022 -11.05 Mn
Jun 30, 2022 -13.21 Mn
Mar 31, 2022 -14.26 Mn
Dec 31, 2021 -8.38 Mn
Sep 30, 2021 -12.99 Mn
Jun 30, 2021 -10.28 Mn
Mar 31, 2021 -12.51 Mn