Cue Biopharma (CUE) EBITDA (2017 - 2025)
Cue Biopharma's (CUE) quarterly EBITDA came in at $23.0 million in Q4 2025, up 342.72% year-on-year from $5.2 million in Q4 2024, and up 409.51% quarter-over-quarter from -$7.4 million in Q3 2025.
Cue Biopharma (CUE) EBITDA (2017 - 2025) Analysis & Trends
Cue Biopharma has disclosed EBITDA across 9 years of filings, most recently posting $23.0 million for Q4 2025.
- EBITDA for Q4 2025 came in at $23.0 million, up 342.72% year-over-year; the trailing twelve-month figure through Dec 2025 was -$5.1 million (up 87.37% YoY), and the FY2025 annual result was -$5.5 million, up 86.52% from the prior year.
- EBITDA came in at $23.0 million for Q4 2025 at Cue Biopharma, up from -$7.4 million in the prior quarter.
- In the past five years, EBITDA ranged from a high of $23.0 million in Q4 2025 to a low of -$14.6 million in Q4 2022.
- The 5-year median for EBITDA is -$11.7 million (2022), against an average of -$9.7 million.
- Across the five-year window, EBITDA slumped 74.09% in 2022 and jumped 342.72% in 2025, its largest moves.
- Cue Biopharma's EBITDA stood at -$8.4 million in 2021, then slumped by 74.09% to -$14.6 million in 2022, then advanced by 7.96% to -$13.4 million in 2023, then advanced by 29.31% to -$9.5 million in 2024, then soared by 342.72% to $23.0 million in 2025.
- The last three EBITDA figures came in at $23.0 million (Q4 2025), -$7.4 million (Q3 2025), and -$8.5 million (Q2 2025), per Business Quant data.
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | EBITDA (Qtr) |
|---|---|---|---|---|---|
| 1 | Alterity Therapeutics | 925,601.88 Bn | 925,601.85 Bn | - | - |
| 2 | Belite Bio | 58,560.00 Bn | 58,560.00 Bn | - | -26.92 Mn |
| 3 | Quantum Biopharma | 17,284.41 Bn | 17,284.40 Bn | - | -13.63 Mn |
| 4 | Legend Biotech | 2,809.00 Bn | 2,808.71 Bn | 242.10 Mn | -19.70 Mn |
| 5 | Evaxion A | 1,334.43 Bn | 1,334.42 Bn | - | -3.82 Mn |
| 6 | Akari Therapeutics | 1,312.27 Bn | 1,312.26 Bn | - | -14.44 Mn |
| 7 | Psyence Biomedical | 212.16 Bn | 212.16 Bn | - | -752,618.00 |
| 8 | Vertex Pharmaceuticals | 114.83 Bn | 107.58 Bn | 2.59 Bn | 1.14 Bn |
| 9 | Abivax | 91.96 Bn | 91.96 Bn | - | -65.83 Mn |
| 10 | Cue Biopharma | 581.16 Mn | 553.47 Mn | - | 23.05 Mn |
Historic Data
Download Data| Date | Value |
|---|---|
| Dec 31, 2025 | 23.05 Mn |
| Sep 30, 2025 | -7.45 Mn |
| Jun 30, 2025 | -8.48 Mn |
| Mar 31, 2025 | -12.26 Mn |
| Dec 31, 2024 | -9.50 Mn |
| Sep 30, 2024 | -8.66 Mn |
| Jun 30, 2024 | -10.17 Mn |
| Mar 31, 2024 | -12.35 Mn |
| Dec 31, 2023 | -13.43 Mn |
| Sep 30, 2023 | -11.00 Mn |
| Jun 30, 2023 | -13.15 Mn |
| Mar 31, 2023 | -13.05 Mn |
| Dec 31, 2022 | -14.60 Mn |
| Sep 30, 2022 | -11.05 Mn |
| Jun 30, 2022 | -13.21 Mn |
| Mar 31, 2022 | -14.26 Mn |
| Dec 31, 2021 | -8.38 Mn |
| Sep 30, 2021 | -12.99 Mn |
| Jun 30, 2021 | -10.28 Mn |
| Mar 31, 2021 | -12.51 Mn |