Clene (CLNN) Operating Income (2020 - 2025)

Clene's Operating Income history runs 6 years deep, the most recent figure standing at -$7.5 million for Q4 2025.

• In Q4 2025, Operating Income fell 146.47% year-over-year to -$7.5 million; the TTM figure through Dec 2025 stood at -$23.1 million (down 179.71% YoY), while the FY2025 annual figure was -$23.1 million, down 179.12% from the prior year.
• Operating Income was -$7.5 million for Q4 2025 at Clene, down from -$5.6 million in the prior quarter.
• In the past five years, Operating Income ranged from a high of $20.2 million in Q4 2023 to a low of -$14.1 million in Q4 2021.
• Historically, Operating Income has averaged -$7.0 million across 5 years, with a median of -$9.7 million in 2022.
• The sharpest annual moves came in 2021 and 2023: Operating Income plunged 236.6% in 2021, then soared 272.88% in 2023.
• A 5-year view of Operating Income shows it stood at -$14.1 million in 2021, then increased by 16.77% to -$11.7 million in 2022, then jumped by 272.88% to $20.2 million in 2023, then fell by 20.26% to $16.1 million in 2024, then sank by 146.47% to -$7.5 million in 2025.
• The last three Operating Income figures came in at -$7.5 million (Q4 2025), -$5.6 million (Q3 2025), and -$5.9 million (Q2 2025), per Business Quant data.