Celcuity (CELC) Operating Income (2016 - 2025)
Celcuity (CELC) posted Operating Income of -$49.2 million for Q4 2025, down 14.82% on a QoQ basis from -$42.8 million in Q3 2025, and down 35.06% year-over-year from -$75.8 million in Q4 2024.
Celcuity (CELC) Operating Income (2016 - 2025) Analysis & Trends
Celcuity's Operating Income history runs 10 years deep, the most recent figure standing at -$49.2 million for Q4 2025.
- Quarterly Operating Income fell 35.06% year-over-year to -$49.2 million in Q4 2025, while the trailing twelve-month figure through Dec 2025 was -$172.2 million (down 52.02% YoY) and the FY2025 annual result came in at -$172.2 million, down 52.02% from the prior year.
- Operating Income was -$49.2 million for Q4 2025 at Celcuity, down from -$42.8 million in the prior quarter.
- Across five years, Operating Income topped out at -$2.8 million in Q1 2021 and bottomed at -$49.2 million in Q4 2025.
- A 5-year average of -$21.0 million and a median of -$17.0 million in 2023 frame the typical range for Operating Income.
- Annual changes were most pronounced in 2021 — Operating Income plunged 516.25% — and 2022, when it increased 29.63%.
- Celcuity's Operating Income stood at -$6.3 million in 2021, then sank by 84.14% to -$11.6 million in 2022, then slumped by 69.51% to -$19.7 million in 2023, then slumped by 84.65% to -$36.4 million in 2024, then slumped by 35.06% to -$49.2 million in 2025.
- Business Quant data shows CELC's Operating Income at -$49.2 million in Q4 2025, -$42.8 million in Q3 2025, and -$44.0 million in Q2 2025.
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Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Op. Inc (Qtr) |
|---|---|---|---|---|---|
| 1 | Oculis Holding AG | 67,072.09 Bn | 67,072.09 Bn | - | -27.75 Mn |
| 2 | Nanobiotix | 1,894.61 Bn | 1,894.55 Bn | - | - |
| 3 | Akari Therapeutics | 1,014.18 Bn | 1,014.18 Bn | - | -15.76 Mn |
| 4 | BeOne Medicines | 471.64 Bn | 466.85 Bn | 1.35 Bn | 249.90 Mn |
| 5 | Vertex Pharmaceuticals | 121.72 Bn | 114.47 Bn | 2.59 Bn | 1.14 Bn |
| 6 | Regeneron Pharmaceuticals | 68.28 Bn | 59.52 Bn | 3.31 Bn | 642.90 Mn |
| 7 | Belite Bio | 61.40 Bn | 61.40 Bn | - | -32.68 Mn |
| 8 | Argenx Se | 56.94 Bn | 56.94 Bn | 1.18 Bn | 394.00 Mn |
| 9 | Revolution Medicines | 37.37 Bn | 37.37 Bn | - | -445.22 Mn |
| 10 | Celcuity | 3.89 Bn | 3.89 Bn | - | -49.20 Mn |
Historic Data
Download Data| Date | Value |
|---|---|
| Dec 31, 2025 | -49.20 Mn |
| Sep 30, 2025 | -42.85 Mn |
| Jun 30, 2025 | -44.01 Mn |
| Mar 31, 2025 | -36.13 Mn |
| Dec 31, 2024 | -36.43 Mn |
| Sep 30, 2024 | -30.06 Mn |
| Jun 30, 2024 | -24.28 Mn |
| Mar 31, 2024 | -22.49 Mn |
| Dec 31, 2023 | -19.73 Mn |
| Sep 30, 2023 | -18.90 Mn |
| Jun 30, 2023 | -15.06 Mn |
| Mar 31, 2023 | -12.55 Mn |
| Dec 31, 2022 | -11.64 Mn |
| Sep 30, 2022 | -10.64 Mn |
| Jun 30, 2022 | -9.60 Mn |
| Mar 31, 2022 | -7.51 Mn |
| Dec 31, 2021 | -6.32 Mn |
| Sep 30, 2021 | -5.60 Mn |
| Jun 30, 2021 | -13.64 Mn |
| Mar 31, 2021 | -2.79 Mn |